A5077095329- Synthesis and biological activity
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Gout, Hyperuricemia, Uric Acid
- Biochemical and Molecular Research
- Multicomponent Synthesis of Heterocycles
- Hepatitis C virus research
- Click Chemistry and Applications
- Synthesis of Organic Compounds
- Eosinophilic Disorders and Syndromes
- Free Radicals and Antioxidants
- Neuroscience and Neuropharmacology Research
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation
- Agriculture, Water, and Health
- Complementary and Alternative Medicine Studies
- Receptor Mechanisms and Signaling
- Chemical synthesis and pharmacological studies
- Millimeter-Wave Propagation and Modeling
- Breast Cancer Treatment Studies
- Andrographolide Research and Applications
- Estrogen and related hormone effects
- Curcumin's Biomedical Applications
- Phosphodiesterase function and regulation
- HER2/EGFR in Cancer Research
Government Medical College, Amritsar
2022-2024
Guru Nanak Dev University
2018-2022
Shri Mata Vaishno Devi University
2022
Indian Institute of Management Amritsar
2018
Keeping in view various pharmacological attributes of indole and coumarin derivatives, a new series indolindione-coumarin molecular hybrids was rationally designed synthesized. All synthesized hybrid molecules were evaluated for their antimicrobial potential against Gram-negative bacterial strains (Escherichia coli Salmonella enterica), Gram-positive (Staphylococcus aureus Mycobacterium smegmatis), four fungal (Candida albicans, Alternaria mali, Penicillium sp., Fusarium oxysporum) by using...
Keeping in view various pharmacological attributes of curcumin, coumarin, and isatin derivatives, triazole-tethered monocarbonyl curcumin-coumarin curcumin-isatin molecular hybrids have been synthesized evaluated for their antibacterial potential against Gram-positive (Enterococcus faecalis Staphylococcus aureus) Gram-negative (Pseudomonas aeruginosa Escherichia coli) human pathogenic bacterial strains. Among all hybrid molecules, A-4 B-38 showed the most potent activity with inhibition...
A novel series of triazole-linked isatin-indole-3-carboxaldehyde hybrids based on the febuxostat skeleton and its binding site interactions were rationally designed synthesized as potential xanthine oxidase inhibitors. Among hybrids, A19 showed most potent inhibition (IC50 = 0.37 µM) with mixed-type inhibitory scenario. Structure-activity relationship studies revealed that methoxy (OCH3 ) substitution position 5 isatin nucleus a two-carbon distance between triazole moiety is tolerable for...
Abstract Considerable ingenuity has been shown in the recent years discovery of novel xanthine oxidase (XO) inhibitors that fall outside purine scaffold. The triazole nucleus cornerstone for development many enzyme clinical management several diseases, where hyperuricemia is one them. Here, we give a critical overview significant research on triazole‐based XO inhibitors, with respect to their design, synthesis, inhibition potential, toxicity, and docking studies, done till now. Based these...
In continuous efforts to develop anti-Alzheimer's agents, we rationally designed and synthesized a series of multitargeting molecules by incorporating the essential molecular features standard drug donepezil. Among series, compound 4b showed properties act as an agent, which is better tolerable in vivo than Acetylcholinesterase (AChE) inhibition data that inhibits enzyme with half-maximal inhibitory concentration (IC50) value 0.78 μM also DNA protection, was confirmed through nicking assay,...
Lack of treatment novel Coronavirus disease led to the search specific antivirals that are capable inhibit replication virus. The plant kingdom has demonstrated be an important source new molecules with antiviral potential.The present study aims utilize various computational tools identify most eligible drug candidate have capabilities halt SARS-COV-2 virus by inhibiting Main protease (Mpro) enzyme.We selected plants whose extracts inhibitory potential against previously discovered...
Novel coronavirus disease, a serious challenge for the healthcare system, has diverted all researchers toward exploration of potential targets, compounds or vaccines management this disease. Mpro enzyme was found to be crucial replication virus which makes an attractive drug target SARS-CoV-2. Diverse pharmacological profile Alkannin/shikonin (A/S) derivatives build up curiosity study their antiviral profile. Therefore, current utilises various computational tools screen and evaluate...
Induction of hypersensitivity reactions (may be fatal too) by specific XO inhibitors has led to development new molecules that are efficacious and have safer ADME profile. Among natural compounds, biologically active Alkannin/Shikonin (A/S) derivatives unexplored inhibition potential. Therefore, their iso-hexenylnaphthazarin nucleus was studied found the is similar allopurinol, signifying inhibitory potential these derivatives. For confirmation potential, β,β-dimethylacrylshikonin...
In a continued effort to develop potent cholesterol esterase (CEase) inhibitors, series of 5,6-benzoflavone derivatives was rationally designed and synthesized by changing the position benzene ring attached flavone skeleton in previously reported 7,8-benzoflavones. All compounds were checked for their inhibitory potential against using spectrophotometric assay. Among forty compounds, seven (B-10 B-16) exhibited above 90 percent inhibition CEase an vitro enzymatic Compound B-16 showed most...
Keeping in view the successive attributes of benzodiazepines on central nervous system, we have synthesized a novel series benzodiazepine derivatives as antioxidant and anxiolytic agents. All compounds were obtained good yield by facile synthesis. To check their potential, DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay was performed. Among all synthetics seven (SD-3, SD-5, SD-7, SD-14, SD-18, SD-19, SD-20) exhibited IC50 values ranging from 76-489 nM. These further...
The diet is one of the most important entity for Vrutti (Sustenance life). major treatises Ayurveda (Brihattrayi), namely Charak Samhita, Sushruta Samhita and Ashtanga Hridaya (sometimes, Sangraha also) give logical didactic explanation it. present review was aimed at compiling available information about importance Ahara (diet) from these four treatises. can be helpful understanding various concepts related to food in implied future studies.
 Charaka with Dipika commentary by...