A5101607759- Toxin Mechanisms and Immunotoxins
- Signaling Pathways in Disease
- Thermodynamic properties of mixtures
- Heat shock proteins research
- Chemical and Physical Properties in Aqueous Solutions
- Genomics and Phylogenetic Studies
- Computational Drug Discovery Methods
- Peptidase Inhibition and Analysis
- Cassava research and cyanide
- Agricultural Economics and Practices
- Microbial Community Ecology and Physiology
- Phase Equilibria and Thermodynamics
- Biomedical Text Mining and Ontologies
- Crystallography and molecular interactions
- Malaria Research and Control
- Gene expression and cancer classification
- Crime Patterns and Interventions
- Agronomic Practices and Intercropping Systems
- Genetics, Bioinformatics, and Biomedical Research
- Rice Cultivation and Yield Improvement
- Identification and Quantification in Food
- Vector-borne infectious diseases
- Molecular Spectroscopy and Structure
- Agricultural Science and Fertilization
- Insect Resistance and Genetics
Hans Raj Mahila Maha Vidyalaya
2013-2024
Indian Council of Medical Research
2024
Lovely Professional University
2021-2024
Guru Nanak Dev University
2013-2023
Institute of Microbial Technology
2022
Surface (Brazil)
2022
Punjab Technical University
2021
Indian Institute of Management Amritsar
2016-2018
University of Minnesota
2013-2017
Centre of Advanced Studies
2016
The partial molar volumes V2° and viscosity B-coefficient have been measured from density flow time measurements for sulphanilamide, sulphanilic acid, sulphosalicylic acid dihydrate in water aqueous solutions of (0.05, 0.1, 0.3, 0.5) mol·kg−1 sodium chloride at temperatures (288.15 to 318.15) K, by the use a vibrating tube digital densimeter Micro-Ubbelohde type capillary viscometer, respectively. transfer infinite dilution calculated both positive negative values. overall values higher...
In continuous efforts to develop anti-Alzheimer's agents, we rationally designed and synthesized a series of multitargeting molecules by incorporating the essential molecular features standard drug donepezil. Among series, compound 4b showed properties act as an agent, which is better tolerable in vivo than Acetylcholinesterase (AChE) inhibition data that inhibits enzyme with half-maximal inhibitory concentration (IC50) value 0.78 μM also DNA protection, was confirmed through nicking assay,...
Cyclophilins, which bind to immunosuppressant cyclosporin A (CsA), are ubiquitous proteins and constitute a multigene family in higher organisms. Several members of this reported catalyze cis-trans isomerisation the peptidyl-prolyl bond, is rate limiting step protein folding. The physiological role these plants, with few exceptions, still matter speculation. Although Arabidopsis genome predicted contain 35 cyclophilin genes, biochemical characterization, imperative for understanding their...
Cyanide (CN) toxicity is a serious clinical problem and can occur with sodium nitroprusside (SNP) administration, accidental smoke inhalation, industrial mishaps, bio-terrorism. In this study, we induced severe CN independently SNP or cyanide (NaCN) in juvenile pig model to demonstrate reversal of new antidote, sulfanegen sodium, prodrug 3-mercaptopyruvate.SNP study: A pilot study 11 anesthetized, mechanically ventilated pigs allowed us determine the dose induce toxicity. Blood CN, serum...
Global efforts to eradicate malaria are threatened by multiple factors, particularly the emergence of anti-malarial drug resistant strains Plasmodium falciparum. Heat shock proteins (HSPs), P. falciparum HSPs (PfHSPs), represent promising targets due their essential roles in parasite survival and virulence across various life cycle stages. Despite structural similarities between human malarial posing challenges, there is substantial evidence for subtle differences that could be exploited...
Abstract Standard partial molar isentropic compressibilities, K ○ s,2 at infinite dilution of some mono-, di- and trisaccharides were determined in water (0.5, 1.0, 2.0 3.0) mol kg – 1 aqueous sodium acetate solutions temperatures, T = (288.15, 298.15, 308.15 318.15) from precise speed sound measurements. From these data, the standard compressibilities transfer, Δ t , pair triplet interaction coefficients ( AB ABB ) hydration numbers, N w have been calculated. These parameters discussed...
Plasmodium falciparum is a unicellular protozoan parasite and causative agent of severe form malaria in humans, accounting for very high worldwide fatality rates. At the molecular level, survival within human host mediated by P. heat shock proteins (PfHsps) that provide protection during febrile episodes. The ATP-dependent chaperone activity Hsp70 relies on co-chaperone J domain protein (JDP), with which it forms chaperone-co-chaperone complex. exported JDP (PfJDP), PFA0660w, has been shown...
Plasmodium falciparum is a unicellular, intracellular protozoan parasite, and the causative agent of malaria in humans, deadly vector borne infectious disease. A key phase pathology, invasion human erythrocytes, resulting drastic remodeling by exported parasite proteins, including molecular chaperones co-chaperones. The survival within host mediated P. heat shock protein 70s (PfHsp70s) J domain proteins (PfJDPs), functioning as chaperones-co-chaperones partnerships. Two complexes have been...
Tissue banking informatics deals with standardized annotation, collection and storage of biospecimens that can further be shared by researchers. Over the last decade, Department Biomedical Informatics (DBMI) at University Pittsburgh has developed various tissue tools to expedite translational medicine research. In this review, we describe technical approach capabilities these models.Clinical annotation requires data retrieval from clinical information systems de-identification an honest...
AbstractHydrogen bond acceptor ability of sulfur and oxygen has been analyzed in the adducts dimethyl sulfide ((CH3)2S) ether ((CH3)2O) with H2O, CH3OH, HCOOH, NH2OH, CH3NH2, NH2NH2, HCONH2, HF HCl. The stabilization energies have evaluated using MP2/aug-cc-pVDZ, B3LYP/aug-cc-pVDZ, gaussian2 (G2) complete basis set (CBS) theoretical levels. contributors to are explored by employing symmetry adapted perturbation theory analysis, natural orbital analysis addition molecular methods....
In an attempt to discover a new class of antibacterial agents with improved efficacy and overcome the drug-resistant problems, some novel 4-substituted thieno[2,3-d]pyrimidines have been synthesized via microwave-assisted methodology evaluated for their in vitro activity against various pathogenic bacterial strains. Compounds 12b 13c showed promising inhibitory potencies Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa Escherichia coli MICs ranging from 2 10 μg/ml. Compound...
Abstract Peptidyl-prolyl cis–trans isomerases (PPIases) are the only class of enzymes capable isomerization prolyl peptide bond. The PPIases, comprising different families viz., cyclophilins, FK506-binding proteins (FKBPs), parvulins and protein phosphatase 2A activators (PTPAs), play essential roles in cellular processes. Though PPIase gene have been characterized organisms, information regarding these is lacking Penicillium species, which commercially an important fungi group. In this...
Background: The wheat cyclophilin, TaCYPA-1, shows peptidyl-prolyl cis-trans isomerase (PPIase) activity. However, the significance of different cysteine residues in regulation PPIase activity this protein has not been investigated. Keywords: Cyclophilin, cysteine, redox regulation, isomerase, wheat, heat stress.