A5016240043- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Analysis
- Sulfur-Based Synthesis Techniques
- Catalytic C–H Functionalization Methods
- Synthesis and Biological Evaluation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Click Chemistry and Applications
- Microwave-Assisted Synthesis and Applications
- Synthesis of Organic Compounds
- Quinazolinone synthesis and applications
- Crystallization and Solubility Studies
- Catalytic Cross-Coupling Reactions
- X-ray Diffraction in Crystallography
- Carbohydrate Chemistry and Synthesis
- Catalytic Alkyne Reactions
- Cancer Treatment and Pharmacology
- Cancer therapeutics and mechanisms
- Nanoparticle-Based Drug Delivery
- Synthesis and Reactions of Organic Compounds
- RNA Interference and Gene Delivery
- Computational Drug Discovery Methods
- Synthesis and pharmacology of benzodiazepine derivatives
- Synthesis and Characterization of Pyrroles
KU Leuven
2010-2025
Texas Tech University
2022-2023
Texas Tech University Health Sciences Center
2022-2023
University of Nebraska Medical Center
2018-2022
Indo Soviet Friendship College of Pharmacy
2013-2019
Punjab Technical University
2014-2018
Pandit Sundarlal Sharma Open University
2018
Maine Organic Farmers and Gardeners Association
2016
Fistulacure
2015-2016
Alltech (United States)
2016
To dissect the antibiotic role of nanostructures from chemical moieties belligerent to both bacterial and mammalian cells, here we show antimicrobial activity cytotoxicity nanoparticle-pinched polymer brushes (NPPBs) consisting chemically inert silica nanospheres systematically varied diameters covalently grafted with hydrophilic that are non-toxic non-bactericidal. Assembly polymers into nanostructured NPPBs doesn't alter their amicability but it incurs a transformation potential against...
Alkaloids of the naamine family were synthesized from diverse propargylamines in just two steps (see scheme: R1=Me, R2=substituted benzyl, R3=Ar). Thus, addition to a propargylamine carbodiimide generated situ, silver(I)-catalyzed intramolecular hydroamidation, and subsquent deprotection provide access heterocyclic core numerous natural products biologically active compounds. Boc=tert-butoxycarbonyl, Cbz=carbobenzyloxy.
Three-component coupling reaction: An efficient, microwave-assisted, CuI-catalysed A3-coupling reaction with primary aliphatic amines that gives access to secondary propargylamines is described (see scheme). Detailed facts of importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the authors. Please note: The publisher responsible for content functionality any supporting...
An unprecedented, diversity-oriented strategy for the generation of 6,7-dihydro-5H-dibenzo[c,e]azepines and 5,6,7,8-tetrahydrodibenzo[c,e]azocines by a microwave-assisted copper-catalyzed intramolecular A3-coupling reaction is presented.
Glycyrrhetinic acid-modified chitosan (mGA-suc-CTS) is used as liver-targeted carrier for drug delivery. In this study, nanoparticles were prepared by ionic gelation process, and glycyrrhetinic acid act the targeting ligand. The structure of product was confirmed IR NMR techniques. main aim study to deliver atorvastatin directly liver using same conjugate reduce associated side-effects, i.e. hepatotoxicity at high dose. Characterization developed formulation performed differential scanning...
Abstract Nanocarriers have the capability to deliver a variety of drugs disease sites. Different biological barriers prevent successful delivery nanoformulations target sites, thereby limiting effective therapeutic response. Although numerous efforts been made design novel nanocarriers by incorporating various functionalities get better therapies, most strategies failed translate drug systems clinic. Impediments such as incapability hold stably in during circulation, non‐specific...
Amphipathic styrene-maleic acid (SMA) copolymers directly solubilize biomembranes into SMA-lipid particles, or SMALPs, that are often regarded as nanodiscs and hailed a native membrane platform. The promising outlook of SMALPs inspires the discovery many SMA-like also putative nanodiscs, but fundamental question remains on how much SMALP analogues truly resemble bilayer structure nanodiscs. This unfortunate ambiguity undermines utility SMA in biology because function proteins depend...