A5005048394- Microbial Metabolic Engineering and Bioproduction
- Gene expression and cancer classification
- Evolution and Genetic Dynamics
- Biomedical Text Mining and Ontologies
- Molecular Biology Techniques and Applications
- Gene Regulatory Network Analysis
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Genetics, Bioinformatics, and Biomedical Research
- Bacterial Genetics and Biotechnology
- Bioinformatics and Genomic Networks
- RNA Research and Splicing
- Viral Infectious Diseases and Gene Expression in Insects
- Evolutionary Game Theory and Cooperation
- Cognitive Science and Mapping
- Gut microbiota and health
- Natural Language Processing Techniques
- Computational Physics and Python Applications
- Topic Modeling
- Bacteriophages and microbial interactions
- Evolutionary Algorithms and Applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Biofuel production and bioconversion
- RNA modifications and cancer
- Advanced Database Systems and Queries
Singapore Management University
2019-2024
Temasek Polytechnic
2020-2024
MOH Holdings
2019-2024
Northumbria University
2019-2024
University of Roehampton
2023
Perdana University
2018-2023
Infineon Technologies (Singapore)
2019
The University of Melbourne
2007-2018
Nanyang Technological University
2007-2017
Association for Computing Machinery
2006-2014
Lactobacillus acidophilus is a commonly used probiotic that offers numerous health benefits in the human gut, particularly addressing various disorders. L. North Carolina Food Microbiology (NCFM), specific and well-characterized strain, has been classified by US FDA as “Generally Recognized As Safe” (GRAS) for inclusion dairy fermentation formulations, highlighting its potential engineered applications. Mathematical kinetic models allow development of time-course profiles metabolites...
Abstract Background To automatically process large quantities of biological literature for knowledge discovery and information curation, text mining tools are becoming essential. Abbreviation recognition is related to NER can be considered as a pair task terminology its corresponding abbreviation from free text. The successful identification definition not only prerequisite index terms databases produce articles interests, but also building block improve existing gene mention tagging...
Abstract Background Recent studies had found thousands of natural antisense transcripts originating from the same genomic loci protein coding genes but opposite strand. It is unclear whether majority are functional or merely transcriptional noise. Results Using Affymetrix Exon array with a modified cDNA synthesis protocol that enables genome-wide detection transcription, we conducted large-scale expression analysis in nine corresponding tissues human, mouse and rat. We detected transcripts,...
ChatGPT has gained both positive and negative publicity after reports suggesting that it is able to pass various professional licensing examinations. This suggests may Turing Test in the near future. However, a computer program passing can either mean Chinese Room or artificially conscious. Hence, question of whether current state more approaching artificial consciousness remains. Here, I demonstrate version (Feb 13 version) Room. Despite potential evidence cognitive connections, exhibits...
Stutzerimonas balearica (formerly, known as Pseudomonas balearica) is an environmentally tolerant bacterium with denitrification and bioremediation capabilities.Hence, it has been studied for industrial applications; such as, high-value chemical production using metabolic engineering or synthetic biology approaches.Mathematical modelling the potential to predict biological phenotypes under perturbations, which can be used guide approaches.However, there no mathematical model of S. to-date.In...
The expressions of reference genes used in gene expression studies are assumed to be stable under most circumstances. However, a number had demonstrated that such were found vary experimental conditions. In addition, stably expressed an organ may not other organs or organisms, suggesting the need identify for each and organism. This study aims at identifying Escherichia coli. Microarray datasets from E. coli substrain MG1655 1 dataset W3110 analysed. Coefficient variance (COV) was calculated...
Escherichia coli ( E. ) is a nonhalophilic microbe and used to indicate faecal contamination. Salt (sodium chloride, NaCl) common food additive in preservatives encounter microbial growth. The effect of how interacts with the salt present human diet unclear. Thus, it important investigate this relationship. In order adapt survive changes environment, may undergo halophilization. study, we observed genetic growth kinetics ATCC 8739 under 3%–11% NaCl over 80 passages. Our results suggest that...
Escherichia coli is commonly found in intestine of human, and any changes their adaptation or evolution may affect the human body. The relationship between E. food additives less studied as compared to antibiotics. within our gut are consistently interacting with additives; thus, it important investigate this relationship. In paper, we observed cultured different concentration (sodium chloride, benzoic acid, monosodium glutamate), singly combination, over 70 passages. Adaptability time was...
Substance use/abuse is a public health concern with long history and mathematical modelling an important tool to study its epidemiology.Recently, showed that adding 2 processes into 6-compartment model 15 can drastically affect the conclusions, illustrating importance of more complete but complicated model.A systematic review in 2022 presented 24 ordinary differential equations (ODE) models substance epidemiology.This aims assemble these ODE models, for single use only, by stepwise analysis...
Deinococcota, or Deinococcus-Thermus, is a phylum of highly environmentally tolerant extremophiles with value in industrial applications and evolution studies.Phylogenetics using core genome an important aspect evolutionary studies.However, the Deinococcota has not yet been identified.In this study, we report 6 species-specific genomes Deinococcota.However, from 72 strains across 40 species consist only one gene -beta subunit DNA-directed RNA polymerase.This surprisingly small may be result...
Lung cancer is a common cancer, and expression profiling can provide an accurate indication to advance the medical intervention. However, this requires availability of stably expressed genes as reference. Recent studies had shown that are in tissue may not be other tissues suggesting need identify each for use reference genes. DNA microarray analysis has been used those with low fluctuation. Fourteen datasets different lung conditions were employed our study. Coefficient variance, followed...
Escherichia coli is a widely studied prokaryotic system. A recent study had demonstrated that reduced growth of E. after extended culture in Luria-Bertani broth result depletion fermentable sugars but able to sustain cell due the presence amino acids, which can be utilized as carbon source. However, this not been other media. The aimed determine and viability ATCC 8739 3 different media, Nutrient Broth (NB), Brain Heart Infusion (BHI) (LB) over 11 weeks.Growth was determined by optical...
Difference in gene expressions is characteristic of the function different cell types and those genes with low expression variance can be used as standards for quantitative studies. Microarray technology to study global within a cell; hence, represents suitable source data mine variance. The coefficient variation (COV) each was determined threshold less than 0.1 COV select stably expressed set. Our results showed that microtubule affinity-regulating kinase 3 (MARK3) has lowest eight...
Microarrays are a large-scale expression profiling method which has been used to study the transcriptome of plants under various environmental conditions. However, manual inspection microarray data is difficult at genome level because large number genes (normally least 30,000) and many different processes that occur within any given plant. MapMan software, was initially developed visualize for Arabidopsis, adapted other plant species by mapping onto ontology. This paper provides detailed...
Modeling and simulation are recognized as important aspects of the scientific method for more than 70years but its adoption in biology has been slow.Debates on representativeness, usefulness, whether effort spent such endeavors is worthwhile, exist to this day.Here, I argue that most learning modeling; hence, arriving at a contradiction if models not useful.Representing biological systems through mathematical can be difficult modeling procedure process itself follows semi-formal set...