A5082759614- Synthesis and biological activity
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Gout, Hyperuricemia, Uric Acid
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Antifungal resistance and susceptibility
- Bioactive Compounds and Antitumor Agents
- Biochemical and Molecular Research
- Hepatitis C virus research
- Wound Healing and Treatments
- Cancer therapeutics and mechanisms
- Multicomponent Synthesis of Heterocycles
- Estrogen and related hormone effects
- Pharmacological Effects of Medicinal Plants
- Natural Antidiabetic Agents Studies
- Bioactive natural compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Nanoparticles: synthesis and applications
- Environmental Toxicology and Ecotoxicology
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Genomics, phytochemicals, and oxidative stress
- Antimicrobial Resistance in Staphylococcus
- Pharmacological Effects of Natural Compounds
Guru Nanak Dev University
2019-2024
National Renewable Energy Laboratory
2024
Imperial College London
2024
University of Colorado Boulder
2024
Leibniz-Institute for New Materials
2024
Environmental Energy & Engineering
2024
The University of Adelaide
2024
Keeping in view various pharmacological attributes of indole and coumarin derivatives, a new series indolindione-coumarin molecular hybrids was rationally designed synthesized. All synthesized hybrid molecules were evaluated for their antimicrobial potential against Gram-negative bacterial strains (Escherichia coli Salmonella enterica), Gram-positive (Staphylococcus aureus Mycobacterium smegmatis), four fungal (Candida albicans, Alternaria mali, Penicillium sp., Fusarium oxysporum) by using...
Keeping in view various pharmacological attributes of curcumin, coumarin, and isatin derivatives, triazole-tethered monocarbonyl curcumin-coumarin curcumin-isatin molecular hybrids have been synthesized evaluated for their antibacterial potential against Gram-positive (Enterococcus faecalis Staphylococcus aureus) Gram-negative (Pseudomonas aeruginosa Escherichia coli) human pathogenic bacterial strains. Among all hybrid molecules, A-4 B-38 showed the most potent activity with inhibition...
Abstract Despite a significant work that has been done on thiophene, continuous efforts are still being made by the researchers to identify novel heterocyclic compounds with potential bioactivities. Thiophene nucleus extensively utilized across globe for development of diverse bioactive heterocycles hitting wide range biological targets. This review throws light synthetic approaches have used synthesis thiophene derivatives followed depth analysis them respect their pharmacological...
A novel series of triazole-linked isatin-indole-3-carboxaldehyde hybrids based on the febuxostat skeleton and its binding site interactions were rationally designed synthesized as potential xanthine oxidase inhibitors. Among hybrids, A19 showed most potent inhibition (IC50 = 0.37 µM) with mixed-type inhibitory scenario. Structure-activity relationship studies revealed that methoxy (OCH3 ) substitution position 5 isatin nucleus a two-carbon distance between triazole moiety is tolerable for...
Breast cancer is the most common among women. Currently, it poses a significant threat to healthcare system due emerging resistance and toxicity of available drug candidates in clinical practice, thus generating an urgent need for development new potent safer anti-breast candidates. Coumarin (chromone-2-one) elite ring widely distributed natural products possesses broad range pharmacological properties. The unique distribution efficacy coumarins attract product hunters, resulting...
Keeping in view the emerging need for potent and safer anti-breast cancer agents as well pharmacological attributes of isatin, quinolone, morpholine derivatives, novel hydrazine-linked morpholinated isatin-quinoline hybrids were designed, synthesized, evaluated agents. The synthesized hybrid compounds preliminarily screened against two breast cell lines (MCF-7 MDA-MB-231). Almost all synthetics showed inhibitory potential hormone-positive MCF-7 cells while being inactive hormone-negative...
Nanoformulation-based combinational drug delivery systems are well known to overcome resistance in cancer management. Among them, nanoemulsions well-known and thermodynamically stable suitable for carrying hydrophobic drugs phytoconstituents tackle drug-resistant cancers. In the present study, we have investigated effect of paclitaxel combination with erucin (natural isothiocyanate isolated from seeds Eruca sativa) loaded frankincense oil-based nanoemulsion formulation. The choice oil...
Lack of treatment novel Coronavirus disease led to the search specific antivirals that are capable inhibit replication virus. The plant kingdom has demonstrated be an important source new molecules with antiviral potential.The present study aims utilize various computational tools identify most eligible drug candidate have capabilities halt SARS-COV-2 virus by inhibiting Main protease (Mpro) enzyme.We selected plants whose extracts inhibitory potential against previously discovered...