A5100706588- Synthesis and biological activity
- Click Chemistry and Applications
- Genetic Mapping and Diversity in Plants and Animals
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Organic and Inorganic Chemical Reactions
- Plant-Microbe Interactions and Immunity
- Signaling Pathways in Disease
- Biochemical and Molecular Research
- Toxin Mechanisms and Immunotoxins
- Wheat and Barley Genetics and Pathology
- Synthesis of heterocyclic compounds
- Synthesis and Biological Evaluation
- Cancer-related molecular mechanisms research
- Ferrocene Chemistry and Applications
- Synthesis of Tetrazole Derivatives
- Enzyme Catalysis and Immobilization
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Multicomponent Synthesis of Heterocycles
- Synthesis and Catalytic Reactions
- Plant tissue culture and regeneration
- Cancer, Hypoxia, and Metabolism
- Enzyme-mediated dye degradation
Indo Soviet Friendship College of Pharmacy
2024-2025
Guru Nanak Dev University
2011-2024
Desh Bhagat Ayurvedic College and Hospital
2024
Amity University
2024
Government Medical College, Amritsar
2024
Punjab Agricultural University
2019-2023
Pittsburg State University
2023
University of Münster
2021
Chitkara University
2021
National Institute of Technology Kurukshetra
2014-2020
Levels of miR-22-3p, a highly abundant hepatic microRNA, are abnormally increased in mouse models insulin resistance and type 2 diabetes, yet its contribution to deregulated metabolism under diseased states is not well understood. Here, we unravel novel link between elevated miR-22-3p expression impaired gluconeogenesis diabetic db/db mice via the regulation Tcf7 (transcription factor 7). Our data demonstrate that binds 3′ untranslated region TCF7 downregulates it, this microRNA-mediated...
α-Functionalization of conjugated nitroalkenes and nitrodienes using various electrophiles in the presence amine catalysts such as imidazole DMAP synthetic applications products are reviewed. The include formaldehyde, activated non-enolizable carbonyl compounds, imines, azodicarboxylates well alkenes nitroalkenes, MVK acrylate. Reports on products, though only appearing last three years, highlight potential these multi-functional scaffolds to take part diverse transformations Michael...
A novel series of triazole-linked isatin-indole-3-carboxaldehyde hybrids based on the febuxostat skeleton and its binding site interactions were rationally designed synthesized as potential xanthine oxidase inhibitors. Among hybrids, A19 showed most potent inhibition (IC50 = 0.37 µM) with mixed-type inhibitory scenario. Structure-activity relationship studies revealed that methoxy (OCH3 ) substitution position 5 isatin nucleus a two-carbon distance between triazole moiety is tolerable for...
Breast cancer is the most common among women. Currently, it poses a significant threat to healthcare system due emerging resistance and toxicity of available drug candidates in clinical practice, thus generating an urgent need for development new potent safer anti-breast candidates. Coumarin (chromone-2-one) elite ring widely distributed natural products possesses broad range pharmacological properties. The unique distribution efficacy coumarins attract product hunters, resulting...
Abstract The aim of the present study was to investigate poikilocytosis in Labeo rohita (an important food fish) as an early indicator stress due azo dye, Basic Violet-1 (CI: 42535). This dye observed be very toxic test fish (96 h LC 50 as0.45 mg/L dye). Fish were given short-term h) and subchronic (150 days) exposures recorded under light scanning electron microscopy (SEM). Light helped identification micronuclei along with irregularities, notches, blebs, lobes, crenation, clumps, chains,...
Shoot fly (Atherigona naqvii) is one of the major insects affecting spring maize in North India and can cause yield loss up to 60 per cent. The genetics insect resistance complex as influenced by genotypic background, population climatic conditions. Therefore, quantitative trait loci (QTL) mapping a highly effective approach for studying genetically forms resistance. objective present study was dissect genetic basis identification genomic regions associated with shoot A total 107 F2 derived...
Abstract Southern leaf blight (SLB) caused by the fungus C ochliobolus heterostrophus (Drechs.) Drechs. is a major foliar disease of maize worldwide. Our objectives were to identify quantitative trait loci (QTL) for resistance SLB and flowering traits in recombinant inbred line (RIL) population derived from cross lines LM5 (resistant) CM140 (susceptible). A set 207 RILs phenotyped at three time intervals two consecutive years. Four putative QTL detected on chromosomes 3, 8 9 that accounted...
Background: The wheat cyclophilin, TaCYPA-1, shows peptidyl-prolyl cis-trans isomerase (PPIase) activity. However, the significance of different cysteine residues in regulation PPIase activity this protein has not been investigated. Keywords: Cyclophilin, cysteine, redox regulation, isomerase, wheat, heat stress.
Thirty different wheat genotypes, including landraces, cultivars, and related wild species, were analyzed for puroindoline genes proteins. Full-length Pina Pinb amplified using gene-specific markers where 13 genotypes both genes, while 17 had either one or none of the genes. None detected in any Triticum durum cultivars. Genotypes with a soft grain texture, other hard grains. Related nonprogenitor species A, C, M, U, S genomes also showed presence indicating that these can be utilized...