Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and major cause cancer related deaths worldwide. Only 10 to 20% HCC can be surgically excised. Therefore, chemotherapeutic intervention treatment essential for achieving favorable prognosis. However, therapeutic outcome chemotherapy generally poor owing inherent resistance cells or due development acquired resistance. To differentiate delineate molecular events, we developed drug resistant Hep3B (DRC) by treating with...

Abstract Background p53 is the most studied tumor suppressor and its overexpression may or not cause cell death depending upon genetic background of cells. degraded by human papillomavirus (HPV) E6 protein in cervical carcinoma. Several stress activated kinases are known to phosphorylate and, among them cyclin dependent kinase 5 (Cdk5) one neuronal system. Recently, involvement Cdk5 phosphorylating has been shown certain cancer types. Phosphorylation at specific serine residues essential for...

Cyclin-dependent kinase 9 (CDK-9) controls the activation of primary inflammatory response genes. The purpose this study was to determine whether CDK-9 inhibition protects cartilage from catabolic effects proinflammatory cytokines.Human chondrocytes were challenged with different stimuli (interleukin-1β [IL-1β], lipopolysaccharides, and tumor necrosis factor α) in presence or absence either inhibitor flavopiridol small interfering RNA (siRNA). expression messenger (mRNA) for mediator genes,...

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide that particularly refractory to chemotherapy. Several studies have proposed combination chemotherapy regimen for HCC treatment. However, these therapies are not effective in regressing tumor and prolonging survival patient's suffering from HCC. Therefore, development more therapeutic tools new strategies treatment urgently needed. Over last decade much attention has been focused on "bystander effect" as a possible...

Chondrosarcoma is a form of malignant skeletal tumor cartilaginous origin. The non-malignant the disease termed chondroma. Correctly distinguishing between two forms essential for making therapeutic decisions. However, due to their similar histological appearances and lack reliable diagnostic marker, it often difficult distinguish benign tumors from low-grade chondrosarcoma. Therefore, necessary search potential marker that has prognostic values in In this study, we demonstrated by...

Background Hepatocellular carcinoma (HCC) is leading cause of cancer-related mortality and categorized among the most common malignancies around world. It a heterogeneous tumor, which shows significant degree histopathological heterogeneity. Despite apparent diversity there has been very little distinct correlation between features molecular aberrations particularly when it comes to expression level Wnt Hh pathway molecules. The role pathways in relation HCC behavior viz. heterogeneity...

Hepatocellular Carcinoma (HCC) is the leading cause of cancer-related mortality across world. Non-viral etiological factors including obesity and metabolic syndrome have now become prevalent hepatocellular carcinoma. Sonic Hedgehog (SHH) pathway activated in carcinoma but its role regulation lipogenic molecules during hepatocarcinogenesis not known. The aim present study to explore SHH fatty changes associated with at different stages further correlate expression pathways.Our results...

OBJECTIVETo compare the efficacy of oral nifedipine and IV Labetalol in acute blood pressure control severe preeclampsia. METHODS200 women with ≥160mmHg systolic and/or ≥110mmHg diastolic were randomized to receive (10 mg tablet orally up five doses) or labetalol escalating doses 20mg, 40mg, 80mg, 80mg 80mg.They administered drugs every 15 minutes until was less than equal 150mm Hg 100mm diastolic.Crossover treatment if initial failed.The time required reduce target value, number adverse...

The oncogene leukemia/lymphoma-related factor (LRF) enhances chondrosarcoma proliferation and malignancy. This study aimed to investigate the roles of LRF in chondrogenic differentiation primary human bone marrow-derived mesenchymal stem cells (BMSCs).LRF was overexpressed BMSC by lentiviral transduction. Chondrogenic induced high-density pellet culture. Western blotting real-time polymerase chain reaction were used changes protein mRNA levels, respectively, during chondrogenesis. Safranin-O...

Aims: The study aims to comprehensively analyze diabetic nephropathy's risk factors and treatment patterns, exploring diverse for enhanced prevention personalized management.
 Study Design: Prospective design.
 Place Duration of Study: was conducted 5 months at Trust Multispeciality Hospital, Kakinada.
 Methodology: This retroactive chart analysis non-critical outpatients folders Hospital that refers the mentioned period (11/2022 -04/2023) will use Excel software.
...

Angioleiomyomas are relatively common neoplasms in skin and superficial planes of extremities (89%), head (48%) trunk (14%).These tumours extremely rare uterus with very few cases described the literature.These have been varied names like angiomyoma, angioleiomyoma, or vascular leiomyoma.There is no description angioleiomyoma as an entity a variant leiomyoma latest WHO classification uterine tumours.There mention differential diagnosis hemangioma under mesenchymal tumors but provided.A...

Helicobacter pylorus (H. pylori) is a deadly bacterium responsible for significant worldwide Gastric Cancer (GC) related mortality. The present study aimed to screen all the anti-microbial drugs used eradicate H .pylori infection and identify most efficient drug by using computational methods through molecular docking analysis. 3-D structure of protein chorismate synthase H. pylori was downloaded from Protein data bank (PDB) online browser. x-ray crystallography structures 13 common against...

Seizures are the most common neurological illness in pediatric population and account for 1% of all emergency department (ED) visits 2% to children's hospital EDs. Pediatric epilepsy presents with various diagnostic challenges. Neuroimaging, especially structural neuroimaging preferably MRI brain, plays an essential role diagnosing, managing, guiding treatment.The study aimed estimate clinical spectrum seizures children examine findings seizures.The was a hospital-based retrospective...

OBJECTIVE:The aim of this study was to find out the maternal outcome in emergency and elective caesarean sections compare intraoperative postoperative complications sections.METHOD: In hospital based descriptive 100 cases section (EMCS) were compared with (ELCS) over a period 2 years department obstetrics gynaecology Niloufer Hospital, Hyderabad.The pregnant women any parity or age admitted through OPD during period.Data collection included age, parity, indication for section, blood loss...

Primary fallopian tube carcinoma (PFTC) is rare and constitutes about 0.14% to 1.8% of all female genital (gynaecological) malignancies.It so that it often mistaken histologically clinically for ovarian cancer.It arises in post menopausal women typically presents with vaginal bleeding, pelvic pain watery discharge.We present a case primary 55yr old nulliparous who presented bleeding.

Introduction: Tuberculosis (TB) represents a global epidemic and causes significant mortality mostly in developing countries. With the emergence of HIV pandemic steady decline incidence tuberculosis was halted developed countries fact it is reversed. Similarly an diabetes mellitus sweeping country. Aims Objectives: Isolation Mycobacterium on solid media from different groups like HIV/AIDS patients, Diabetics, immunocompetent persons to study isolation rates smear negative suspected cases....

Novel Approaches in Cancer Study Bridging the Gap between Pre-Clinical and Clinical Studies Research Ratna Kumari* DBT BIOCARe Scientist, India *Corresponding author:Ratna Kumari, Submission: May 01, 2019;Published: 09, 2019 DOI: 10.31031/NACS.2019.02.000545 ISSN:2637-773XVolume2 Issue4