A5005131093- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Pancreatic and Hepatic Oncology Research
- Pancreatic function and diabetes
- Neonatal Health and Biochemistry
- Adenosine and Purinergic Signaling
- Mitochondrial Function and Pathology
- Advanced Proteomics Techniques and Applications
- RNA modifications and cancer
- Microbial Metabolic Engineering and Bioproduction
- Autophagy in Disease and Therapy
- Biochemical and Molecular Research
- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
Princeton University
2020-2024
Ludwig Cancer Research
2021-2024
In Nrf2-activated tumors, G6pd inhibition depletes TCA intermediates and suppresses tumor growth.
The enzyme glucose-6-phosphate dehydrogenase (G6PD) is a major contributor to NADPH production and redox homeostasis its expression upregulated correlated with negative patient outcomes in multiple human cancer types. Despite these associations, whether G6PD essential for tumor initiation, growth, or metastasis remains unclear. Here, we employ modern genetic tools evaluate the role of lung, breast, colon driven by oncogenic K-Ras. Human HCT116 colorectal cells lacking exhibited metabolic...
Immune checkpoint blockade (ICB) has transformed cancer treatment, but success rates remain low in most cancers. Recent research suggest that dietary fiber enhances ICB response melanoma patients and murine preclinical models through microbiome-dependent mechanisms. Yet, the robustness of this effect across types contexts remains unclear. Specifically, prior literature compared grain-based chow (high fiber) to low-fiber purified diet, these diets differ also on other dimensions including...
Nucleotides perform important metabolic functions, carrying energy and feeding nucleic acid synthesis. Here, we use isotope tracing-mass spectrometry to quantitate the contributions purine nucleotides of salvage versus
<p>This file contains additional figures related to findings from the described subcutaneous xenograft experiments, primary murine NSCLC experiments and metastatic breast cancer experiments. In addition, it a table listing oligonucleotide sequences utilized in our genetic studies.</p>
<p>This file contains additional figures related to findings from the described subcutaneous xenograft experiments, primary murine NSCLC experiments and metastatic breast cancer experiments. In addition, it a table listing oligonucleotide sequences utilized in our genetic studies.</p>
<div>Abstract<p>The enzyme glucose-6-phosphate dehydrogenase (G6PD) is a major contributor to NADPH production and redox homeostasis its expression upregulated correlated with negative patient outcomes in multiple human cancer types. Despite these associations, whether G6PD essential for tumor initiation, growth, or metastasis remains unclear. Here, we employ modern genetic tools evaluate the role of lung, breast, colon driven by oncogenic K-Ras. Human HCT116 colorectal cells...
<div>Abstract<p>The enzyme glucose-6-phosphate dehydrogenase (G6PD) is a major contributor to NADPH production and redox homeostasis its expression upregulated correlated with negative patient outcomes in multiple human cancer types. Despite these associations, whether G6PD essential for tumor initiation, growth, or metastasis remains unclear. Here, we employ modern genetic tools evaluate the role of lung, breast, colon driven by oncogenic K-Ras. Human HCT116 colorectal cells...