A5107335606- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Neuroscience and Neuropharmacology Research
- Ocular Oncology and Treatments
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Antibiotics Pharmacokinetics and Efficacy
- Advanced Neuroimaging Techniques and Applications
- Micro and Nano Robotics
- Electrochemical Analysis and Applications
- Ion channel regulation and function
- Microfluidic and Capillary Electrophoresis Applications
- Mathematical Biology Tumor Growth
- Systemic Lupus Erythematosus Research
- Corneal Surgery and Treatments
- Anesthesia and Sedative Agents
- Facial Trauma and Fracture Management
- Ocular Infections and Treatments
- Hemostasis and retained surgical items
Vantage View (United States)
2019-2024
Acumen (United States)
2024
University of California, San Diego
2017-2021
Smith-Kettlewell Eye Research Institute
2017-2020
New York University
2000-2019
Shantou University
2016-2019
The Retina Center
2018
Jacobs (United States)
2018
NYU Langone Health
2014-2017
VA Pittsburgh Healthcare System
2017
Diffusion of molecules in brain extracellular space is constrained by two macroscopic parameters, tortuosity factor λ and volume fraction α. Recent studies slices show that when osmolarity reduced, increases while α decreases. In contrast, with increased osmolarity, increases, but attains a plateau. Using homogenization theory variety lattice models, we found the plateau behavior can be explained if shape cells changes nonuniformly during shrinking or swelling induced osmotic challenge. The...
It has long been assumed that one important mechanism for the dissipation of local potassium gradients in brain extracellular space is so-called spatial buffer, generally associated with glial cells. To date, however, there no analytical description characteristic patterns K+ clearance mediated by such a mechanism. This study reanalyzed mathematical model Gardner-Medwin (1983, J. Physiol. (Lond.). 335:393–426) had previously solved numerically. Under suitable approximations, transient...
To evaluate the spectrum of macular chorioretinal lesions occurring in idiopathic multifocal choroiditis using optical coherence tomography angiography (OCTA) to those showing neovascular flow.This was a descriptive, retrospective study 18 eyes 14 patients with choroiditis. Macular were characterized as subretinal pigment epithelium, subretinal, or mixed and evaluated during active presumed inactive states Correlations between structural OCTA performed. In select cases, correlations OCTA,...
To evaluate depth of field, lateral resolution, and image quality a heads-up 3D visualization system for vitreoretinal surgery using physician survey optical measurement outcomes.
To describe anatomical relationships of retinal neovascular complexes (NVCs) and the posterior vitreous in proliferative diabetic retinopathy using spectral domain optical coherence tomography.Cross-sectional study. Neovascular were imaged tomography 51 eyes 37 patients. The relationship NVCs to cortex spaces, such as premacular bursa, prevascular fissures, perimacular cisterns, was analyzed.In 77 evaluated, 61 (79%) had grown along outer surface hyaloid face, vitreoschisis present (48%)....
Purpose: To assess early retinal microvascular and functional changes in diabetic patients without clinical evidence of retinopathy with optical coherence tomography angiography central visual analyzer. Methods: This was an observational case–control study nondiabetic controls. Patients underwent imaging acuity testing using the The foveal avascular zone area capillary density superficial deep plexuses were measured manually by a masked grader. Results: Sixty eyes from 35 included group, 45...
To describe ocular findings in 3 cases of solar retinopathy using high definition, spectral domain optical coherence tomography (SD-OCT) and review the literature for (OCT) characteristics associated with worse vision.Case series retrospective clinical features Spectralis SD-OCT (Heidelberg Engineering, Vista, California, United States America). A OCT reported on MEDLINE was also performed analyzed.Six eyes patients revealed significant foveal pathology. Visual acuity ranged from Snellen...
Background . The association between patient demographics and CV events after ADT using real‐world data was evaluated. In addition to encompassing >30 times more patients than all previous MACE studies, this is the first study, best of our knowledge, include a comprehensive listing many demographic factors from one large, recent US dataset over long period time. Materials Methods retrospective analysis in Decision Resources Group (now Clarivate) Real World Evidence repository,...
Abstract In this paper, we further develop the general theory of microdialysis by extending linear model Bungay et al . to provide a theoretical basis for in vitro and vivo microdialysis. Specifically, considered effect active clearance processes on microdialysis, thereby elaborated Benveniste endogenous compounds. We examined use steady state tissue diffusion resistance with negligible interpret data. The influence properties recoveries dual‐probe was analyzed simulated operating parameters...
To describe atypical cases of multiple evanescent white dot syndrome (MEWDS) associated with foveal exudation, increased choroidal thickness, and secondary Type 2 (subretinal) neovascularization.Four MEWDS were studied at a retina referral center. Patients underwent evaluation multimodal retinal imaging, including fluorescein angiography, indocyanine green spectral-domain enhanced depth imaging optical coherence tomography (OCT). Two patients imaged OCT angiography.Four (3 female, 1 male)...
Abstract Dual‐probe microdialysis was used to study interstitial diffusion in the rat brain. A radiolabelled tracer, [ 3 H]mannitol, continuously infused at different concentrations via a probe acutely implanted into striatum of an anaesthetized male or dilute agar gel. Samples were collected by second placed 1 mm away from first, and recovered H]mannitol measured liquid scintillation counting. In striatum, delivery counteracted its removal extracellular space passive uptake cells clearance...
To report the swept-source optical coherence tomography (SS-OCT) findings in a case of acute toxoplasmosis chorioretinitis.A 35-year-old male presented with blurry vision and floaters his left eye. Ophthalmic examination, color photographs, spectral-domain OCT (SD-OCT), enhanced depth imaging (EDI-OCT), SS-OCT wide-field fluorescein angiography images were obtained to diagnose follow subsequent changes chorioretinitis over 2-month period.Initial different modalities SD- EDI-OCT including...
Water compartmentalization was studied in a thick-slice (1000 μm) model of ischemia by combining water-content measurements with extracellular diffusion analysis. Thick slices bathed artificial cerebrospinal fluid continually gained water. Total tissue water content increased 67% after 6 hours the incubation. Diffusion using tetramethylammonium method showed that space, typically occupying 20% brain vivo, decreased to 10% at 30 minutes and 15% both deep superficial layers thick slices....
ObjectiveAutomated Machine Learning (AutoML) has emerged as a novel tool for medical professionals lacking coding experience, enabling them to develop predictive models treatment outcomes. This study evaluated the performance of AutoML tools in developing predicting success pneumatic retinopexy (PR) rhegmatogenous retinal detachment (RRD). These were then compared with custom created by ML experts.DesignRetrospective multicenter study.Population539 consecutive patients primary RRD that...
Abstract Steady‐state microdialysis is a widely used technique to monitor the concentration changes and distributions of substances in tissues. To obtain more information about brain tissue properties from microdialysis, dual‐probe approach was applied infuse sample radiotracer, [ 3 H]mannitol, simultaneously both agar gel rat striatum. Because molecules released by one probe collected other must diffuse through interstitial space, profile exhibits dynamic behavior that permits assessment...
Extracellular diffusion in the brain is customarily characterized by two parameters, extracellular space (ECS) volume fraction α and tortuosity λ. How these parameters are temporarily modified correlated a physiological/pathological event remains unclear to date. Using tetramethylammonium (TMA + ) as an ECS ion tracer newly updated iontophoretic sinusoidal method, we studied this work dynamic α( t) λ( rat somatosensory cortex during spreading depression (SD). Temporal variations of t),...
Purpose: To compare retinal pathology visualization in multispectral scanning laser ophthalmoscope imaging between the Spectralis and Optos devices. Methods: This retrospective cross-sectional study included 42 eyes from 30 patients with age-related macular degeneration (19 eyes), diabetic retinopathy (10 epiretinal membrane (13 eyes). All underwent a color fundus camera (broad-spectrum white light), HRA-2 system (3-color monochromatic lasers), P200 (2-color lasers). The image was cropped to...