A5018690367- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanofabrication and Lithography Techniques
- Bone Tissue Engineering Materials
- Laser Material Processing Techniques
- Cellular Mechanics and Interactions
- Microfluidic and Capillary Electrophoresis Applications
- Plasmonic and Surface Plasmon Research
- Microfluidic and Bio-sensing Technologies
- Tissue Engineering and Regenerative Medicine
- Nonlinear Optical Materials Studies
- Neuroscience and Neural Engineering
- Cancer Cells and Metastasis
- Electrowetting and Microfluidic Technologies
- Coral and Marine Ecosystems Studies
- Near-Field Optical Microscopy
- Electrospun Nanofibers in Biomedical Applications
- Nerve injury and regeneration
- Advanced MEMS and NEMS Technologies
- Photopolymerization techniques and applications
- Algal biology and biofuel production
- Biocrusts and Microbial Ecology
- Thermal Radiation and Cooling Technologies
- Photonic Crystals and Applications
University of California, San Diego
2016-2025
La Jolla Bioengineering Institute
2016-2024
Sichuan University
2018-2023
Bioengineering Center
2021
University of California System
2018-2019
State Key Laboratory of Biotherapy
2018
Zhejiang University
2014-2018
The University of Texas at Austin
2004-2017
Atkins (United States)
2012-2016
Ruijin Hospital
2015
The functional maturation and preservation of hepatic cells derived from human induced pluripotent stem (hiPSCs) are essential to personalized in vitro drug screening disease study. Major liver functions tightly linked the 3D assembly hepatocytes, with supporting cell types both endodermal mesodermal origins a hexagonal lobule unit. Although there many reports on 2D differentiation, few studies have demonstrated hiPSC-derived progenitor (hiPSC-HPCs) environment that depicts physiologically...
A stereolithography-based bioprinting platform for multimaterial fabrication of heterogeneous hydrogel constructs is presented. Dynamic patterning by a digital micromirror device, synchronized moving stage and microfluidic device containing four on/off pneumatic valves, used to create 3D constructs. The novel capable fast switching between different (cell-loaded) bioinks, achieve layer-by-layer bioprinting. Compared conventional bioprinters, the system provides unique advantage capability at...
Abstract Our ability to create precise, pre‐designed, spatially patterned biochemical and physical microenvironments inside polymer scaffolds could provide a powerful tool in studying progenitor cell behavior differentiation under biomimetic, three‐dimensional (3D) culture conditions. We have developed simple fast, layer‐by‐layer microstereolithography system consisting of an ultra‐violet light source, digital micro‐mirror masking device, conventional computer projector, that allows...
Here we demonstrate that efficient piezoelectric nanoparticle–polymer composite materials can be optically printed into three-dimensional (3D) microstructures using digital projection printing. Piezoelectric polymers were fabricated by incorporating barium titanate (BaTiO3, BTO) nanoparticles photoliable polymer solutions such as polyethylene glycol diacrylate and exposing to optical masks could dynamically altered generate user-defined 3D microstructures. To enhance the...
The topographic features of the extracelluar matrix (ECM) lay foundation for cellular behavior. A novel biofabrication method using a digital-mirror device (DMD), called dynamic optical projection stereolithography (DOPsL) is demonstrated. This robust and versatile platform can generate complex biomimetic scaffolds within seconds. Such 3D have promising potentials studying cell interactions with microenvironments in vitro vivo. Detailed facts importance to specialist readers are published as...
Rationally designed nanoparticles that can bind toxins show great promise for detoxification. However, the conventional intravenous administration of detoxification often leads to nanoparticle accumulation in liver, posing a risk secondary poisoning especially liver-failure patients. Here we present liver-inspired three-dimensional (3D) device. This device is created by 3D printing designer hydrogels with functional polydiacetylene installed hydrogel matrix. The attract, capture and sense...
Hydrogel microfish featuring biomimetic structures, locomotive capabilities, and functionalized nanoparticles are engineered using a rapid 3D printing platform: microscale continuous -optical (μCOP). The 3D-printed -microfish exhibit chemically powered magnetically guided propulsion, as well highly efficient detoxification capabilities that highlight the technical versatility of this platform for engineering advanced functional microswimmers diverse biomedical applications.
Currently, the performances of thin film solar cells are limited by poor light absorption and carrier collection. In this research, large, broadband, polarization-insensitive enhancement was realized via integrating with unique metallic nanogratings. Through simulation, three possible mechanisms were identified to be responsible for such an enormous enhancement. A test totaling over spectrum shows up approximately 30% broadband when comparing bare cells.
Three-dimensional (3D) printing technology has great potential in advancing clinical medicine. Currently, the vivo application strategies for 3D-printed macroscale products are limited to surgical implantation or situ 3D at exposed trauma, both requiring exposure of site. Here, we show a digital near-infrared (NIR) photopolymerization (DNP)-based that enables noninvasive bioprinting tissue constructs. In this technology, NIR is modulated into customized pattern by micromirror device, and...
Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain tumor microenvironment in a reproducible and scalable system, we developed rapid three-dimensional (3D) bioprinting method to construct clinically relevant biomimetic tissue models. In recurrent glioblastoma, macrophages/microglia prominently contribute mass. parse function of macrophages 3D, compared growth glioblastoma stem cells (GSCs) alone or astrocytes neural precursor hyaluronic acid-rich...
Three-dimensional (3D) bioprinting techniques have emerged as the most popular methods to fabricate 3D-engineered tissues; however, there are challenges in simultaneously satisfying requirements of high cell density (HCD), viability, and fine fabrication resolution. In particular, resolution digital light processing-based 3D suffers with increasing bioink due scattering. We developed a novel approach mitigate this scattering-induced deterioration The inclusion iodixanol enables 10-fold...