The intravitreal delivery of therapeutic agents promises major benefits in the field ocular medicine. Traditional methods rely on random, passive diffusion molecules, which do not allow for rapid a concentrated cargo to defined region at posterior pole eye. use particles targeted but faces challenge that most tissues including vitreous have tight macromolecular matrix acts as barrier and prevents its penetration. Here, we demonstrate novel microvehicles-slippery micropropellers-that can be...

We describe fuel-free, near-infrared (NIR)-driven Janus mesoporous silica nanoparticle motors (JMSNMs) with diameters of 50, 80, and 120 nm. The structure the JMSNMs is generated by vacuum sputtering a 10 nm Au layer on one side MSNMs. Upon exposure to an NIR laser, localized photothermal effect half-shells results in formation thermal gradients across JMSNMs; thus, self-thermophoresis can actively drive nanomotors move at ultrafast speed, for instance, up 950 body lengths/s 50 under laser...

Recently, tremendous progress in synthetic micro/nanomotors diverse environment has been made for potential biomedical applications. However, existing micro/nanomotor platforms are inefficient deep tissue imaging and motion control

A neutrophil-hybrid microrobot is capable of active accumulation close to the brain and penetration across blood-brain barrier.

Nanotransporters: Self-assembled polymer multilayer nanorockets based on a template-assisted layer-by-layer technique can self-propel by chemical power, namely hydrogen peroxide degradation. They perform drug loading, targeted transportation, and triggered release an external physical stimuli in controlled manner. As service to our authors readers, this journal provides supporting information supplied the authors. Such materials are peer reviewed may be re-organized for online delivery, but...

Stem cell membrane-coated nanogels can effectively evade clearance of the immune system, enhance tumor targeting properties and antitumor chemotherapy efficacy gelatin loaded doxorubicin in mice.

Attempts to apply artificial nano/micromotors for diverse biomedical applications have inspired a variety of strategies designing motors with propulsion mechanisms and functions. However, existing are made exclusively synthetic materials, which subject serious immune attack clearance upon entering the bloodstream. Herein we report an elegant approach that turns natural red blood cells (RBCs) into functional micromotors aid ultrasound magnetic guidance. Iron oxide nanoparticles loaded RBCs,...

Hydrogel microfish featuring biomimetic structures, locomotive capabilities, and functionalized nanoparticles are engineered using a rapid 3D printing platform: microscale continuous -optical (μCOP). The 3D-printed -microfish exhibit chemically powered magnetically guided propulsion, as well highly efficient detoxification capabilities that highlight the technical versatility of this platform for engineering advanced functional microswimmers diverse biomedical applications.

Efficient and controlled nanoscale propulsion in harsh environments requires careful design manufacturing of nanomachines, which can harvest translate the propelling forces with high spatial time resolution. Here we report a new class artificial nanomachine, named magneto–acoustic hybrid nanomotor, displays efficient presence either magnetic or acoustic fields without adding any chemical fuel. These fuel-free nanomotors, comprise helical structure concave nanorod end, are synthesized using...

We describe an approach to modulating the on-demand motion of catalytic polymer-based microengines via near-infrared (NIR) laser irradiation. The polymer multilayer motor was fabricated by template-assisted layer-by-layer assembly and subsequently deposition platinum nanoparticles inside a thin gold shell outside. Then mixed monolayer tumor-targeted peptide antifouling poly(ethylene glycol) functionalized on shell. remain motionless at critical peroxide concentration (0.1%, v/v); however,...

A red blood cell membrane‐camouflaged nanowire that can serve as new generation of biomimetic motor sponge is described. The constructed by the fusion biocompatible gold motors and RBC nanovesicles. possesses a high coverage vesicles, which remain totally functional due to its exclusively oriented extracellular portion on surfaces sponge. These display efficient acoustical propulsion, including controlled movement in undiluted whole blood. vesicles highly stable during propulsion process,...

We demonstrate the first example of a self-propelled Janus polyelectrolyte multilayer hollow capsule that can serve as both autonomous motor and smart cargo. This new composed partially coated dendritic platinum nanoparticles (Pt NPs) was fabricated by using template-assisted layer-by-layer (LbL) self-assembly combined with microcontact printing method. The resulting motors still retain outstanding delivery capacities respond to external stimuli for controllable encapsulation triggered...

We present herein a novel hybrid, polymer-based motor that was fabricated by the template-assisted polyelectrolyte layer-by-layer (LbL) deposition of thin gold layer on one side, followed chemical immobilization catalytic enzyme. Such Janus capsule motors can self-propel at 0.1% peroxide fuel concentration physiological temperature and have higher speed as compared to Pt-based synthetic motors. They were exploited for encapsulation chemotherapeutic anticancer drug, doxorubicin, navigation...

We describe a biodegradable, self-propelled bovine serum albumin/poly-l-lysine (PLL/BSA) multilayer rocket as smart vehicle for efficient anticancer drug encapsulation/delivery to cancer cells and near-infrared light controlled release. The rockets were constructed by template-assisted layer-by-layer assembly of the PLL/BSA layers, followed incorporation heat-sensitive gelatin hydrogel containing gold nanoparticles, doxorubicin, catalase. These can rapidly deliver doxorubicin targeted cell...

The unique swimming strategies of natural microorganisms have inspired recent development magnetic micro/nanorobots powered by artificial helical or flexible flagella. However, as nanoswimmers with geometries are being developed, it is critical to explore new potential modes for kinetic optimization. For example, the freestyle stroke most efficient competitive strokes humans. Here we report a type nanorobot, symmetric multilinked two-arm nanoswimmer, capable "freestyle" at low Reynolds...

Abstract Engineering self‐propelled micromotors with good biocompatibility and biodegradability for actively seeking disease sites targeted drug transport remains a huge challenge. In this study, neutrophils intrinsic chemotaxis capability were transformed into self‐guided hybrid by integrating mesoporous silica nanoparticles (MSNs) high loading capability. To ensure the compatibility of neutrophil cells drug‐loaded MSNs, bacteria membranes derived from E. coli coated on MSNs in advance...

A gold nanoshell-functionalized polymer multilayer nanorocket performs self-propulsion upon the irradiation with NIR light in absence of chemical fuel. Theoretical simulations reveal that light-triggered self-thermophoresis drives propulsion nanorocket. The also displays -efficient -biofluids and thus holds considerable promise for various potential biomedical applications.

Photodynamic therapy (PDT) is a promising cancer therapeutic strategy, which typically kills cells through converting nontoxic oxygen into reactive species using photosensitizers (PSs). However, the existing PDTs are still limited by tumor hypoxia and poor targeted accumulation of PSs. To address these challenges, we here report an acoustically powered magnetically navigated red blood cell-mimicking (RBCM) micromotor capable actively transporting PS for enhanced PDT. The RBCM micromotors...

We report an ultrasound-driven gold-nanoshell-functionalized polymer multilayer tubular nanoswimmer that can photomechanically perforate the membrane of a cancer cell by assistance near-infrared (NIR) light. The nanoswimmers were constructed template-assisted layer-by-layer technique and subsequent functionalization Au nanoshells inside big opening. exhibit efficient controllable movement toward target cells through manipulation acoustic field. Next, with end-on attachment onto HeLa achieve...

Swimming microrobots guided in the circulation system offer considerable promise precision medicine but currently suffer from problems such as limited adhesion to blood vessels, intensive flow, and immune clearance-all reducing targeted interaction. A swimming microrobot design with clawed geometry, a red cell (RBC) membrane-camouflaged surface, magnetically actuated retention is discussed, allowing better navigation inspired by tardigrade's mechanical claw engagement, coupled an RBC...

Cell derivatives have received increasing attention due to their unique ability mimic many of the natural properties displayed by source cells. Integration cell‐derived materials with synthetic subjects can be applied toward development novel biomedical nano/microscale devices for a wide range applications, including drug delivery and biodetoxification. Herein, cell membrane functionalized magnesium‐based Janus micromotor, powered water, that mimics motile cells is reported. The new...

Red blood cell (RBC)-based micromotors containing both therapeutic and diagnostic modalities are described as a means for potential theranostic applications. In this natural RBC-based multicargo-loaded micromotor system, quantum dots (QDs), anti-cancer drug doxorubicin (DOX), magnetic nanoparticles (MNPs), were co-encapsulated into RBC micromotors. The fluorescent emission of QDs DOX provides direct visualization their loading inside the motors at two distinct wavelengths. presence MNPs...

Abstract Acoustic assembly promises a route toward rapid parallel fabrication of whole objects directly from solution. This study reports the contact‐free and maskless assembly, fixing silicone particles into arbitrary 2D shapes using ultrasound fields. Ultrasound passes through an acoustic hologram to form target image. The assemble suspension along lines high pressure in image due radiation forces are then fixed (crosslinked) UV‐triggered reaction. For this, loaded with photoinitiator by...