We describe fuel-free, near-infrared (NIR)-driven Janus mesoporous silica nanoparticle motors (JMSNMs) with diameters of 50, 80, and 120 nm. The structure the JMSNMs is generated by vacuum sputtering a 10 nm Au layer on one side MSNMs. Upon exposure to an NIR laser, localized photothermal effect half-shells results in formation thermal gradients across JMSNMs; thus, self-thermophoresis can actively drive nanomotors move at ultrafast speed, for instance, up 950 body lengths/s 50 under laser...

Macrophage cell membrane (MPCM)-camouflaged gold nanoshells (AuNS) that can serve as a new generation of photothermal conversion agents for in vivo cancer therapy are presented. They constructed by the fusion biocompatible AuNSs and MPCM vesicles. The resulting MPCM-coated exhibited good colloidal stability kept original near-infrared (NIR) adsorption AuNSs. Because AuNS carried high-density coverage MPCMs, totally functional portions macrophage cells were grafted onto surface This...

Engineering natural macrophage cell membrane-camouflaged mesoporous silica nanocapsules can reduce the arrested percentage of immune cells and tissues, effectively prolong survival time nanoparticles in blood circulation system, improve accumulation tumor.

Targeted drug delivery is an emerging technological strategy that enables nanoparticle systems to be responsive for tumor therapy. Magnetic mesoporous silica nanoparticles (MMSNs) were cloaked with red blood cell membrane (RBC). This integrates long circulation, photosensitizer delivery, and magnetic targeting cancer In vivo experiments demonstrate RBC@MMSNs can avoid immune clearance achieve field (MF)-induced high accumulation in a tumor. When light irradiation applied, singlet oxygen...

Abstract We report a near‐infrared (NIR) light‐powered Janus mesoporous silica nanomotor (JMSNM) with macrophage cell membrane (MPCM) cloaking that can actively seek cancer cells and thermomechanically percolate membrane. Upon exposure to NIR light, heat gradient across the boundary of JMSNMs is generated by photothermal effect Au half‐shells, resulting in self‐thermophoretic force propels JMSNMs. In biological medium, MPCM camouflaging not only prevent dissociative blocks from adhering but...

We report the construction of erythrocyte membrane-cloaked Janus polymeric motors (EM-JPMs) which are propelled by near-infrared (NIR) laser irradiation and successfully applied in thrombus ablation. Chitosan (a natural polysaccharide with positive charge, CHI) heparin (glycosaminoglycan negative Hep) were selected as wall materials to construct biodegradable biocompatible capsules through layer-by-layer self-assembly technique. By partially coating capsule a gold (Au) layer sputter coating,...

Abstract Engineering self‐propelled micromotors with good biocompatibility and biodegradability for actively seeking disease sites targeted drug transport remains a huge challenge. In this study, neutrophils intrinsic chemotaxis capability were transformed into self‐guided hybrid by integrating mesoporous silica nanoparticles (MSNs) high loading capability. To ensure the compatibility of neutrophil cells drug‐loaded MSNs, bacteria membranes derived from E. coli coated on MSNs in advance...

Abstract Aggregation-induced emission (AIE) has, since its discovery, become a valuable tool in the field of nanoscience. AIEgenic molecules, which display highly stable fluorescence an assembled state, have applications various biomedical fields—including photodynamic therapy. Engineering structure-inherent, nanomaterials with motile properties is, however, still unexplored frontier evolution this potent technology. Here, we present phototactic/phototherapeutic nanomotors where...

Polymersomes with surface-integrated nanoparticles, in which a smaller sphere is attached to larger capsule, are typically formed through complex processes like membrane deformation, polymerization, or functionalization. This complexity restricts facile application of this unusual topology, for example drug delivery nanomotor science. Our study introduces robust method crafting polymersomes nanoparticles using hierarchical phase separation approach. By co-assembling block copolymers aromatic...

Abstract The synthesis of an innovative self‐propelled Janus nanomotor with a diameter about 75 nm that can be used as drug carrier is described. based on mesoporous silica nanoparticles (MSNs) chromium/platinum metallic caps and propelled by decomposing hydrogen peroxide to generate oxygen driving force speeds up 20.2 μm s −1 (about 267 body lengths per second). diffusion coefficient ( D ) nanomotors different H 2 O concentrations calculated tracking the movement individual particles...

Bacterial infections, especially multidrug-resistant bacterial are an increasingly serious problem in the field of wound healing. Herein, cellulose (BC) decorated by 4,6-diamino-2-pyrimidinethiol (DAPT)-modified gold nanoparticles (Au-DAPT NPs) is presented as a dressing (BC-Au-DAPT nanocomposites) for treating bacterially infected wounds. BC-Au-DAPT nanocomposites have better efficacy (measured terms reduced minimum inhibition concentration) than most antibiotics...

Surface engineering of synthetic carriers is an essential and important strategy for drug delivery in vivo. However, exogenous properties make nanosystems invaders that easily trigger the passive immune clearance mechanism, increasing retention effect caused by reticuloendothelial systems bioadhesion, finally leading to low therapeutic efficacy toxic effects. Recently, a cell membrane cloaking technique has been reported as novel interfacing approach from biological/immunological...

A systemic feature of eukaryotic cells is the spatial organization functional components through compartmentalization. Developing protocells with compartmentalized synthetic organelles is, therefore, a critical milestone toward emulating one core characteristics cellular life. Here we demonstrate bottom-up, multistep, noncovalent, assembly rudimentary subcompartmentalized spontaneous encapsulation semipermeable, polymersome proto-organelles inside cell-sized coacervates. The coacervate...

Abstract Photothermal therapy based on gold nanostructures has been widely investigated as a state‐of‐the‐art noninvasive approach. Because single nanoparticles cannot harvest sufficient energy, self‐assemblies of small plasmonic particles into large aggregates are required for enhanced photothermal performance. Self‐assembled nanorods in lipid bilayer‐modified microcapsules shown to localize at tumor sites, generate vapor bubbles under near‐infrared light exposure, and subsequently damage...

Synthetic nanomotors are appealing delivery vehicles for the dynamic transport of functional cargo. Their translation toward biological applications is limited owing to use non-degradable components. Furthermore, size has been an impediment importance achieving nanoscale (ca. 100 nm) dimensions, as opposed microscale examples that prevalent. Herein, we present a hybrid nanomotor can be activated by near-infrared (NIR)-irradiation triggered internal cargo and facilitated external agents cell....

Abstract Aggregation‐induced emission (AIE) is a phenomenon in which fluorescence enhanced rather than quenched upon molecular assembly. AIE fluorogens (AIEgens) are flexible, conjugated systems that limited their dynamics when assembled, improves fluorescent properties. This intriguing feature has been incorporated many different assemblies and extended to nanoparticles composed of amphiphilic polymer building blocks. The integration the fascinating design principle with versatile chemistry...

Supramolecular nanomotors were created with two types of propelling forces that able to counterbalance each other. The particles based on bowl-shaped polymer vesicles, or stomatocytes, assembled from the amphiphilic block copolymer poly(ethylene glycol)-block-polystyrene. first method propulsion was installed by loading nanocavity stomatocytes enzyme catalase, which enabled decomposition hydrogen peroxide into water and oxygen, leading a chemically induced motion. second attained applying...

Abstract Synthetic micro/nanomotors have been extensively exploited over the past decade to achieve active transportation. This interest is a result of their broad range potential applications, from environmental remediation nanomedicine. Nevertheless, it still remains challenge build fast-moving biodegradable polymeric nanomotor. Here we present light-propelled nanomotor by introducing gold nanoparticles (Au NP) onto bowl-shaped polymersomes (stomatocytes) via electrostatic and hydrogen...

Hybrid nano-sized motors with navigation and self-actuation capabilities have emerged as promising nanocarriers for a wide range of delivery, sensing, diagnostic applications due to their unique ability achieve...

Biodegradable nanostructures displaying aggregation-induced emission (AIE) are desirable from a biomedical point of view, due to the advantageous features loading capacity, brightness, and fluorescence stability. Herein, biodegradable polymers comprising poly (ethylene glycol)-block-poly(caprolactone-gradient-trimethylene carbonate) (PEG-P(CLgTMC)), with tetraphenylethylene pyridinium-TMC (PAIE) side chains have been developed, which self-assembled into well-defined polymersomes. The...

Polymersomes that incorporate aggregation-induced emission (AIE) moieties are attractive inherently fluorescent nanoparticles with biomedical application potential for cell/tissue imaging and tracking, as well phototherapeutics. An intriguing feature has not been explored yet is their ability to adopt a range of asymmetric morphologies. Structural asymmetry allows be exploited active (motile) systems. Here, we present the design preparation AIE fluorophore integrated (AIEgenic)...

Single-atom catalysts (SACs) involve atomically dispersed metal atoms on solid supports. SACs combine the fast reaction kinetics of homogeneous with recyclability heterogeneous catalysts, providing great technological opportunities. To date, SAC research has focused primarily development synthetic methods and fuel production. Here, we report a combination nanomotor design to fabricate motile systems, referred here as SAC-nanomotors. This concept is demonstrated by an Fe prepared via pulsing...

Seeking safe and effective water-soluble drug carriers is of great significance in nanomedicine. To achieve this goal, we present a novel delivery system based on biointerfacing hollow polymeric microcapsules for effectively encapsulating antitumor gold nanorod (GNR) functionalization triggered release therapeutic drugs on-demand using low power near-infrared (NIR) radiation. The surface covered with fluidic lipid bilayers to decrease the permeability wall capsules. temperature increase upon...