A5073049010- Polymer Surface Interaction Studies
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Semiconductor materials and devices
- Cellular Mechanics and Interactions
- Marine Biology and Environmental Chemistry
- Nanofabrication and Lithography Techniques
- Osteoarthritis Treatment and Mechanisms
- Surface Modification and Superhydrophobicity
- Hydrogels: synthesis, properties, applications
- Tissue Engineering and Regenerative Medicine
- Knee injuries and reconstruction techniques
- Nanoplatforms for cancer theranostics
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Periodontal Regeneration and Treatments
- Platelet Disorders and Treatments
- Protein Structure and Dynamics
- Cell Adhesion Molecules Research
- Nanoparticle-Based Drug Delivery
- Surgical Sutures and Adhesives
- Orthopaedic implants and arthroplasty
- Advanced Sensor and Energy Harvesting Materials
National Taiwan University
2016-2025
CSIRO Manufacturing
2015
University of South Australia
2012
Industrial Technology Research Institute
2006-2009
University of Taipei
2009
IMEC
2002-2004
University of Washington
1998-2004
University of California, Berkeley
1981
The purpose of this study was to further investigate the role fibrinogen adsorbed from plasma in mediating platelet adhesion polymeric biomaterials. Polystyrene used as a model hydrophobic polymer; i.e., we expected that polystyrene would be representative other polymers. Platelet compared both amount and conformation fibrinogen. strategy compare surfaces preadsorbed with normal, afibrinogenemic, fibrinogen-replenished afibrinogenemic plasmas. determined by lactate dehydrogenase (LDH)...
Abstract Four plasma proteins have been shown to be able mediate platelet adhesion synthetic materials when they are adsorbed as purified proteins: fibrinogen (Fg), fibronectin (Fn), vitronectin (Vn), and von Willebrand factor (vWF). Among them, Fg is thought play a leading role in mediating plasma‐preadsorbed biomaterials, but this has established for only three types of so far our laboratory. Furthermore, the Fn, Vn, vWF surfaces still unclear. The aim current study was assess importance...
Osteointegration of titanium implants in bone defects is clinically important for long-term performance orthopaedic implants. In this work, we developed a facile and effective "one-pot" deposition method based on dopamine polymerization the development cell-adhesive, osteoconductive, osteoinductive Arg-Gly-Asp (RGD)-conjugated polymers, hydroxyapatite (HAp) nanoparticles, morphogenic protein-2 (BMP-2) were mixed with an alkaline solution, then, substrates immersed mixture hour. During...
Abstract Background Alzheimer's disease (AD) is the most common cause of dementia characterized by progressive cognitive impairment in elderly people. The dramatic abnormalities are those cholinergic system. Acetylcholinesterase (AChE) plays a key role regulation system, and hence, inhibition AChE has emerged as one promising strategies for treatment AD. Methods In this study, we suggest workflow identification prioritization potential compounds targeted against AChE. order to elucidate...
A simple technique was developed to fabricate tunable micropatterned substrates based on mussel-inspired surface modification. Polydopamine (PDA) polydimethylsiloxane (PDMS) stamps and easily imprinted several such as glass, silicon, gold, polystyrene, poly(ethylene glycol) via microcontact printing. The PDA retained its unique reactivity could modulate the chemical properties of micropatterns secondary reactions, which illustrated in this study. patterns onto a cytophobic nonfouling were...
Zwitterionic sulfobetaine methacrylate (SBMA) polymers were known to possess excellent antifouling properties due high hydration capacity and neutral charge surface. In this study, copolymers of SBMA acrylic acid (AA) with a variety compositions synthesized immobilized onto polymeric substrates layer-by-layer polyelectrolyte films via electrostatic interaction. The amounts platelet adhesion fibrinogen adsorption determined evaluate hemocompatibility poly(SBMA-co-AA)-modified substrates....
Alignment and fusion of myoblasts into parallel arrays multinucleated myotubes are critical in skeletal muscle tissue engineering. It is well known that contact guidance by grooves/ridges structures induces to align migrate along the anisotropic direction. In this study, two series grooved substrata with different widths (450 900 nm) depths (100, 350, 550 were studied on their effects myoblast adhesion, proliferation, differentiation myotubes. We found C2C12 cells aligned elongated direction...
Abstract The profound effects that nanoscale surface topography exerts on cell behavior are highly relevant to the development of advanced biomaterials and advances in tissue engineering regenerative medicine. Here, an asymmetric anodization procedure is used produce n‐type porous silicon (pSi) gradients with pore sizes ranging from tens hundreds nanometers diameter changes ridge nanoroughness a few nanometers. Rat mesenchymal stem cells (rMSCs) adhere poorly at regions small size but high...
Structural similarity of electrospun fibers (ESFs) to the native extracellular matrix provides great potential for application biofunctional ESFs in tissue engineering. This study aimed synthesize biofunctionalized poly (L-lactide-co-glycolide) (PLGA) investigating cardiac engineering application. We developed a simple but novel strategy incorporate adhesive peptides PLGA ESFs. Two derived from laminin, YIGSR, and RGD, were covalently conjugated poly-L-lysine, then mingled with solution...
In this work, methacrylated gelatin (GelMA) based hydrogels were fabricated with carboxybetaine methacrylate (CBMA) to manipulate the properties of gelatin-based hydrogels, since CBMA is a much smaller compound compared gelatin.
Abstract Hydroxyapatite (HAp) coating on orthopedic implants is a common strategy to increase osteointegration. In this work, facile deposition method based dopamine polymerization was developed for preparation of HAp‐coated titanium substrates applications. Nanostructured HAp mixed with an alkaline solution and then deposited onto form dopamine/HAp ad‐layer. The greatly enhanced the adhesion, proliferation, mineralization osteoblasts. Furthermore, RGD‐containing peptides were immobilized...
Methylene blue (MB) is a widely used dye and photodynamic therapy (PDT) agent that can produce reactive oxygen species (ROS) after light exposure, triggering apoptosis. However, it hard for the to penetrate through cell membrane, leading poor cellular uptake; thus, drug carriers, which could enhance uptake, are suitable solution. In addition, defective vessels resulting from fast vessel outgrowth leads an enhanced permeability retention (EPR) effect, gives nanoscale carriers promising...