A5051737955- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Salivary Gland Disorders and Functions
- Immune cells in cancer
- Endometriosis Research and Treatment
- Autoimmune and Inflammatory Disorders Research
- Neonatal Respiratory Health Research
- Pluripotent Stem Cells Research
- Reproductive System and Pregnancy
- Oral and Maxillofacial Pathology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hematopoietic Stem Cell Transplantation
- Congenital Diaphragmatic Hernia Studies
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Periodontal Regeneration and Treatments
- Oral microbiology and periodontitis research
- Soft tissue tumor case studies
- Neurofibromatosis and Schwannoma Cases
- Olfactory and Sensory Function Studies
- Pregnancy and Medication Impact
- Psoriasis: Treatment and Pathogenesis
- Microwave and Dielectric Measurement Techniques
- SARS-CoV-2 and COVID-19 Research
Taipei Medical University
2023-2025
National Taiwan University
2021-2025
National Taiwan University Hospital
2020-2024
Texas A&M University
2023
National Health Research Institutes
2013-2022
National Defense Medical Center
2013-2018
National Cheng Kung University
2009
Mesenchymal stem/stromal cells (MSCs) are promising potential candidates for the treatment of immunological diseases because their immunosuppressive functions. However, molecular mechanisms that mediate MSCs' activity remain elusive. In this article, we report first time, to our knowledge, secreted growth-regulated oncogene (GRO) chemokines, specifically GRO-γ, in human MSC-conditioned media have an effect on differentiation and function monocyte-derived dendritic cells. The were driven...
Background Environmental etiology of primary Sjögren’s syndrome (pSS), an autoimmune disease, has been proposed. This study determined whether the exposure to air pollutants was independent risk factor for pSS. Methods Participants were enrolled from a population-based cohort registry. Daily average concentrations 2000 2011 divided into 4 quartiles. Adjusted hazard ratios (aHRs) pSS estimated in Cox proportional regression model adjusting age, sex, socioeconomic status, and residential...
Abstract Multilineage tissue-source mesenchymal stem cells (MSCs) possess strong immunomodulatory properties and are excellent therapeutic agents, but require constant isolation from donors to combat replicative senescence. The differentiation of human induced pluripotent (iPSCs) into MSCs offers a renewable source MSCs; however, reports on their capacity have been discrepant. Using differentiated iPSCs reprogrammed using diverse cell types protocols, in comparison embryonic (ESC)-MSCs bone...
Juvenile idiopathic arthritis (JIA), an autoimmune disease, has been proposed to be comorbid with obstructive sleep apnoea (OSA). We aimed at testing the hypothesis that patients JIA may presented high risk of OSA in a cohort study.This is study including from 1999 2013 identified longitudinal health registry. A matched non-JIA control group was also included. The primary outcome variable presence OSA. Cox proportional hazard model developed estimate JIA. cumulative probability adopted...
Abstract Introduction Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder affecting salivary and lacrimal glands, while endometriosis involves uterine‐like tissue growth outside the uterus, causing pelvic pain infertility. Investigating their intricate relationship using real‐world data crucial due to limited research on connection. Material Methods This population‐based cohort study included patients with controls without endometriosis. Propensity score matching was used...
The role of T cells in peri-implant inflammation was evidenced by transcriptomic profiles the epithelium, changes cell immunity, and vivo studies, enhancing our understanding inflammatory complications implant surgeries.
In this letter, with an electric double layer on the surface of spherical viruses, we confirm that one microwave resonant absorption (MRA) mechanisms viruses is through dipolar coupling confined acoustic vibrations. By treating virions as free homogeneous nanoparticles, found MRA frequencies agree well l=1 modes predicted by elastic continuum theory. The magnitude was also to change amount adsorbed charges virions. Our results provide a method observe three-dimensionally vibrations in...
The relationship between uterine corpus cancer and endometriosis was conflicting. We aimed to determine the risk of in patients with or pelvic inflammatory disease (PID). In this population-based cohort study, a total 135,236 females (n = 20,510) PID 114,726), as well age-matched controls, were included. Cox regression models estimated each group. Sub-outcomes for included endometrial sarcoma analyzed. An age subgroup analysis performed moderator effect age. A landmark depicted time varying...
Abstract Introduction Most craniofacial manifestations of neurofibromatosis type 1 (NF1) are considered as a result tumor compression. We sought to determine salivary changes, caries, and periodontal complications in NF1 patients without tumors the oral cavity. Objective methods Eleven cavity 29 matched controls were enrolled this case–control study. Demographic information, medical history, data intraoral examinations, including Decayed, Missing, Filled Teeth (DMFT) scores Russel’s index...
Abstract Background The impact of global overconsumption simple sugars on bone health, which peaks in adolescence/early adulthood and correlates with osteoporosis (OP) fracture risk decades, is unclear. Mesenchymal stromal/stem cells (MSCs) are the progenitors osteoblasts/bone-forming cells, known to decrease their osteogenic differentiation capacity age. Alarmingly, while there correlative evidence that adolescents consuming greatest amounts have lowest mass, no mechanistic understanding...
The combination of radiotherapy and immunotherapy improves the survival rate patients with malignancies developed through escape from T-cell-mediated immune surveillance. Immune checkpoint inhibitors, such as anti-programmed cell death protein-ligand 1 (anti-PD-L1) antibody, are used to rescue exhausted T cells. Simultaneously, dendritic cells (DCs) which antigen-presenting that can initiate T-cell activation, induce a tumor-specific response. However, synergistic antitumor efficacy...
Hypervirulent Klebsiella pneumoniae (hvKP) causes severe infections even in healthy individuals by escaping surveillance and killing from polymorphonuclear neutrophils (PMNs), the first-line leukocytes bacterial infections; moreover, emergence of multidrug-resistant strains further limits treatment options. We therefore assess whether multilineage mesenchymal stem cells (MSCs), best known for immunomodulation toward T cells, could be therapeutic highly virulent via modulation PMNs. find that...
Multipotent human mesenchymal stem cells (MSCs) harbor clinically relevant immunomodulation, and HLA-G, a non-classical MHC class I molecule with highly restricted tissue expression, is one important involved in these processes. Understanding of the natural regulatory mechanisms expression this elusive has been difficult, near exclusive reliance on cancer cell lines. We therefore studied transcriptional control HLA-G primary isolated bone marrow- (BM), embryonic cell-derived (hE-), as well...
Rationale Acute respiratory distress syndrome (ARDS) is a lethal complication of severe bacterial pneumonia due to the inability dampen overexuberant immune responses without compromising pathogen clearance. Both these processes involve tissue-resident and bone marrow (BM)–recruited macrophage (MΦ) populations which can be polarised have divergent functions. Surprisingly, despite known immunomodulatory properties mesenchymal stem cells (MSCs), simultaneous interactions with recruited BMMΦ...