W.-S. Chen

ORCID: 0009-0002-2495-854X
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About
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Research Areas
  • Colorectal Cancer Treatments and Studies
  • Atherosclerosis and Cardiovascular Diseases
  • Systemic Lupus Erythematosus Research
  • Cancer Genomics and Diagnostics
  • Salivary Gland Disorders and Functions
  • Genetic factors in colorectal cancer
  • Renal Diseases and Glomerulopathies
  • Hematopoietic Stem Cell Transplantation
  • DNA Repair Mechanisms
  • Complement system in diseases
  • Spondyloarthritis Studies and Treatments
  • Epigenetics and DNA Methylation
  • Oral Health Pathology and Treatment
  • Abdominal Surgery and Complications
  • Oral health in cancer treatment
  • Gastric Cancer Management and Outcomes
  • T-cell and B-cell Immunology
  • Cancer, Stress, Anesthesia, and Immune Response
  • Genetic Associations and Epidemiology
  • Health Systems, Economic Evaluations, Quality of Life
  • Inflammatory Myopathies and Dermatomyositis
  • Hernia repair and management
  • Neutropenia and Cancer Infections
  • Genomics and Phylogenetic Studies
  • Otitis Media and Relapsing Polychondritis

Guangzhou Medical University
2024

Xidian University
2023

Taipei Veterans General Hospital
1998-2018

National Yang Ming Chiao Tung University
1998-2014

Thrombotic microangiopathy (TMA) co-existing with SLE is rarely reported. This study aimed to investigate the triggering factors, clinical features and outcomes of patients TMA in Northern Taiwan.Twenty-five cases out 2461 admitted Taipei Veterans General Hospital, between 2000 2010, were enrolled.When occurred, 16 (64.0%) had infection; 22 (88.0%) an active disease state a SLEDAI score >10. Among infection group, 13 (81.3%) increase ≥ 4. We found that older age (≥ 50 years), low platelets...

10.1093/rheumatology/keq311 article EN Lara D. Veeken 2010-12-11

This study aimed to identify the risk factors for mortality and impact of dialysis modalities on survival in SLE patients with end-stage renal disease (ESRD).This retrospective nationwide population-based using National Health Insurance Research Database Taiwan collected data from 1073 ESRD starting maintenance between March 1997 December 2006. A multivariate Cox regression hazard model was applied predicting cohorts different outcome these both genders.The major threat infections. For...

10.1093/rheumatology/kes325 article EN Lara D. Veeken 2012-11-30

Bevacizumab added to 5-fluorouracil-based chemotherapy can improve outcomes in patients with metastatic colorectal cancer. had several notable adverse effects including bowel perforation but pneumothorax never been reported the available English literature. We a 45-year-old male lung metastases from cancer who spontaneous after second cycle of bevacizumab-containing chemotherapy. His resolved tube thoracostomy small caliber catheter. The mechanism developed bevacizumab therapy was not clear...

10.1093/jjco/hyq195 article EN Japanese Journal of Clinical Oncology 2010-10-28

Single nucleotide variants (SNVs) are very common in human genome and pose a significant effect on cellular proliferation tumorigenesis various cancers. Somatic variant germline the two forms of SNVs. They major drivers inherited diseases acquired tumors respectively. A reasonable analysis next generation sequencing data profiles from cancer genomes could provide crucial information for diagnosis treatment. Accurate detection SNVs distinguishing still considered challenging tasks analysis....

10.1109/tcbb.2023.3291134 article EN IEEE/ACM Transactions on Computational Biology and Bioinformatics 2023-06-30

<h3>Background</h3> Ankylosing spondylitis (AS) is a form of arthritis that affects the spine. The spinal joints are inflamed causing severe pain and discomfort. Severe effects AS can include new bone formation on spine immobility. It associated with decreased quality-of-life in its patients, pharmacological non-pharmacological treatments available. <h3>Objectives</h3> This research aims to estimate economic burden Taiwan. <h3>Methods</h3> National Health Insurance Research Database (NHIRD),...

10.1136/annrheumdis-2015-eular.1179 article EN Annals of the Rheumatic Diseases 2015-06-01

Between January 1994 and November 1995, 41 patients with metastatic colorectal carcinoma were enrolled in this study. All these had recurrent disease after a prior 5-fluorouracil based adjuvant chemotherapy or failed to achieve response by that included 5-fluorouracil. 5-Fluorouracil, 2600 mg/m2, was administered concurrently 100 mg/m2 leucovorin over 24 hours of continuous intravenous infusion. The treatment repeated every week until progressive documented. Forty-one received total 810...

10.1093/jjco/28.1.16 article EN Japanese Journal of Clinical Oncology 1998-01-01

Chronic graft-versus-host disease (cGVHD) may mimic clinical and serological features of various autoimmune diseases. We present a case 23-year-old man who developed vitiligo, symmetric polyarthritis, high titre rheumatoid factor, antinuclear antibodies anti-double stranded DNA after allogenic peripheral blood stem cell transplantation for severe aplastic anaemia. He was treated with low dose oral steroids, non-steroid anti-inflammatory drugs azathioprine improvement polyarthritis were...

10.1136/bcr.06.2009.1941 article EN BMJ Case Reports 2009-09-02

<h3>Background</h3> Several pathological mechanisiums may underlies an association between sleep apnea and autoimmune diseases. There are few evidances of increasing risk OSA in patients with rheumatoid arthritis, ankylosing spondylitis. The RA or Sjogren syndrome (SS)was thought to be attributed upper airway dryness a resulting colappsibility temporomandibular joint involvement (1,2). asystemic disease nd obstructive were not clear Asian. We hypothesized that diseases would predispose the...

10.1136/annrheumdis-2016-eular.2221 article EN Annals of the Rheumatic Diseases 2016-06-01

<h3>Background</h3> HCQ is an antimalarial drug that widely prescribed for the treatment of Sjögren syndrome. Glucocorticoids may alter glucose metabolism and contribute to diabetes mellitus. Treatment primary syndrome (SS) sometimes requires glucocorticoids worsen homoeostasis. can reduce risk in SLE RA. <h3>Objectives</h3> This study aimed investigate association use mellitus SS patients. <h3>Methods</h3> nationwide, population-based cohort was conducted using Taiwan National Health...

10.1136/annrheumdis-2018-eular.5945 article EN Annals of the Rheumatic Diseases 2018-06-01
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