A5033076020- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Air Quality and Health Impacts
- Occupational exposure and asthma
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Renal cell carcinoma treatment
- Pediatric health and respiratory diseases
- Heart Rate Variability and Autonomic Control
- Dermatology and Skin Diseases
- Indoor Air Quality and Microbial Exposure
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease and Transplantation
- Allergic Rhinitis and Sensitization
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Gallbladder and Bile Duct Disorders
- COVID-19 and Mental Health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Cardiovascular and exercise physiology
Centre Hospitalier Universitaire de Besançon
2016-2024
Institut du Thorax
2024
Hôpital Beaujon
2016-2023
Université Paris Cité
2016-2023
Assistance Publique – Hôpitaux de Paris
2016-2023
GERCOR (France)
2020
Université de Rouen Normandie
2018
Centre Hospitalier Universitaire de Rouen
2018
Laboratoire de recherches Intégratives en Neurosciences et psychologie Cognitive
2013
Sokoine University of Agriculture
2010
Survivors of viral ARDS are at risk long-term physical, functional and neuropsychological complications resulting from the lung injury itself, but also potential multiorgan dysfunction, long stay in intensive care unit (ICU). Recovery profiles after severe SARS-CoV-2 pneumonia survivors have yet to be clearly defined.
Abstract Background Cardiopulmonary exercise testing (CPET) is an important clinical tool that provides a global assessment of the respiratory, circulatory and metabolic responses to which are not adequately reflected through measurement individual organ system function at rest. In context critical COVID-19, CPET ideal approach for assessing long term sequelae. Methods this prospective single-center study, we performed 12 months after symptom onset in 60 patients had required intensive care...
Background and aims Some studies have explored the prevalence of pancreatic cystic lesions (PCLs). Only one study based on magnetic resonance imaging (MRI) report examination focused specifically intraductal papillary mucinous neoplasm (IPMN) in a European general population. The aim this was to evaluate IPMN population patients who had MRI for non‐pancreatic disease. Methods We conducted retrospective, single‐center study. All consecutive placed French liver transplant waiting list disease...
Farmer's lung (FL) is a common type of hypersensitivity pneumonitis. It often considered that fibrosis the most frequent finding in chronic FL. Nevertheless, three cohort studies have suggested some patients with FL may develop emphysema. We aimed to evaluate current prevalence emphysema active FL, describe radiological and functional features identify risk factors associated this population.Patients aged over 18 years were prospectively recruited through SOPHIA study (CPP Est; P-2009-521),...
Summary Background The outcome of cholangiopathy developing in intensive care unit (ICU) is not known patients surviving their ICU stay. Aim To perform a survey liver units, order to clarify the course after Methods files units affiliated French network for vascular disease were screened cases with normal function tests on admission, and no prior history disease. Results Between 2005 2015, 16 retrieved. Extensive burns cause admission 11 patients. Serum alkaline phosphatase levels increased...
Farmers are exposed to multiple air contaminants that may interact with tobacco smoking in the development of respiratory diseases. currently considered smoke less than non-farmers, but precise data different categories age and farming activities lacking.Smoking habits were studied a cross-sectional study involving 4105 farmers 996 non-farming controls aged 40-74 years 9 French departments between October 2012 May 2013. Three groups defined (40-54, 55-64 65-74years). divided into four...
Rationale: In murine models, microbial exposures induce protection from experimental allergic asthma through innate immunity. Objectives: Our aim was to assess the association of early life immunity with development in children at risk. Methods: PASTURE farm birth cohort, T-helper cell type 2 (Th2), Th1, and Th17 cytokine expression age 1 year measured after stimulation peripheral blood mononuclear cells LPS n = 445 children. Children risk were defined based on single-nucleotide...
Background: Chronic obstructive pulmonary disease (COPD) and farming are two conditions that have been associated with an increased risk of anxiety depression. Dairy is independent factor for COPD. Objective: To test the hypotheses prevalence and/or depression higher in dairy farmers COPD than without COPD, non-farmers Methods: Anxiety were evaluated using Hospital Depression Scale 100 (DF-COPD), 98 (DF-controls), 85 non-farming patients (NF-COPD) 89 subjects (NF-controls), all identified by...
Background: Comorbidities including cardiovascular diseases are very common in chronic obstructive pulmonary disease (COPD) secondary to tobacco smoking and contribute the overall severity of disease. In non-smoking COPD, which accounts for about 25% COPD cases worldwide, current knowledge on frequency determinants comorbidities remains scarce. The aims study were assess major evaluate their a group non-selected patients with mild-to-moderate who exposed organic dust (dairy farmers),...
An important window of opportunity for early-life exposures has been proposed the development atopic eczema and asthma.However, it is unknown whether hay fever with a peak incidence around late school age to adolescence similarly determined very early in life.In Protection against Allergy-Study Rural Environments (PASTURE) birth cohort potentially relevant such as farm milk consumption exposure animal sheds were assessed at multiple time points from infancy 10.5 years classified by repeated...
Dyspnea is a common yet poorly understood symptom of long COVID, affecting many patients. This brief report examines the role dysfunctional breathing in persistent dyspnea among patients with mild post-COVID-19 using hyperventilation provocation tests (HVPT). In this case series, six unexplained and normal cardiopulmonary function underwent HVPT. Despite exercise testing results, all exhibited delayed PETCO 2 recovery, indicative pattern consistent chronic syndrome, without typical...
Abstract Background Transepidermal water loss (TEWL) has been used to measure skin barrier function and associated with atopic dermatitis allergic diseases in infancy. However, few studies have assessed the association between TEWL adolescents. Objective To investigate sensitizations 16-year-old Materials methods The study was conducted 78 adolescents of PASTURE study. Different types sensitization (seasonal, perennial, inhalant, food any) were defined using serum specific immunoglobulin E...
Anaemia and organomegaly are among the health problems affecting schoolchildren in Tanzania their causes multifactorial. The objective of this study was to determine prevalence anaemia relationship with single multiple parasitic infections Sengerema District north-west Tanzania. This cross sectional involved 400 schoolchildren. were determined using HemoCue photometer clinical palpation, respectively. A Kato-Katz technique employed screen faecal samples for Schistosoma mansoni other...
Dairy farming is a risk factor for chronic obstructive pulmonary disease (COPD). The aim was to determine predictive markers either in blood samples or dwelling dust by comparing COPD and healthy controls with without activity.Dust collected analyzed real-time quantitative PCR. ELISA DELFIA® were performed assay the level of specific IgG IgE 10 targeted microorganisms.The exposure farmers higher than non-farmers (Especially Eurotium amstelodami Lichtheimia corymbifera). response against...
Allergic mechanisms related to environmental and occupational exposure have been suggested contribute the development of chronic obstructive pulmonary disease (COPD). To investigate relationships between atopy markers, persistent airflow limitation (PAL) in dairy farmers. Clinical biological (total IgE 21 allergen specific IgE) markers were assessed 101 farmers with PAL (DF-PAL), 85 non-farmers (NF-PAL) (both groups prospectively included from a screening program performed 2011 2015),...
Chemotherapy options in patients with advanced pancreatic ductal adenocarcinoma (PDAC) after failure of standard chemotherapies are limited.We aimed to report the efficacy and safety leucovorin 5-fluorouracil (LV5FU2) carboplatin combination this setting.We performed a retrospective study including consecutive PDAC who received LV5FU2-carboplatin between 2009 2021 an expert center.We measured overall survival (OS) progression-free (PFS), explored associated factors using Cox proportional...