A5089167169- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- COVID-19 and healthcare impacts
- COVID-19 Impact on Reproduction
- Long-Term Effects of COVID-19
- Endodontics and Root Canal Treatments
- Medication Adherence and Compliance
- Clostridium difficile and Clostridium perfringens research
- Colorectal Cancer Treatments and Studies
- Eosinophilic Esophagitis
- Periodontal Regeneration and Treatments
- Pharmaceutical studies and practices
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- Virus-based gene therapy research
- IL-33, ST2, and ILC Pathways
- Cancer Research and Treatments
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- Gut microbiota and health
- Economic and Financial Impacts of Cancer
Centre Hospitalier Universitaire de Besançon
2015-2025
Université de franche-comté
2015-2025
Inserm
2015-2025
Établissement Français du Sang
2023-2024
Université Bourgogne Franche-Comté
2016-2023
University of Lausanne
2023
Université de Bourgogne
2021-2022
Clinical Investigation Center Plurithematic Tours
2022
Hôpital Orthopédique de la Suisse Romande
2022
Methodology and Quality of Life Unit in Oncology
2021
Universal cancer peptide-based vaccine (UCPVax) is a therapeutic composed of two highly selected helper peptides to induce CD4+ T helper-1 response directed against telomerase. This phase Ib/IIa trial was designed test the safety, immunogenicity, and efficacy three-dose schedule in patients with metastatic non-small-cell lung (NSCLC).Patients refractory NSCLC were assigned receive three vaccination doses UCPVax (0.25 mg, 0.5 1 mg) using Bayesian-based Ib followed by IIa de-escalating design....
Tissue-resident memory (TRM) T cells have emerged as key players in cancer immunosurveillance, and their presence has been linked to a favorable clinical outcome solid patients. Liver metastases exhibit highly immunosuppressive tumor microenvironment, however, the role impact of TRM cell infiltration colorectal remain elusive. The expression several tissue residency activation biomarkers investigated on tumor-infiltrating lymphocytes isolated from 26 patients' liver (CRC metastases) compared...
Breast Cancer (BC) is the most common type of cancer in women around world and 70% cases are hormone-receptor positive (HR+). In 40% cases, a key mechanism endocrine resistance to standard first line mutation ligand-binding domain (LBD) Estrogen Receptor 1 (ESR1) encoding estrogen receptor α (ER). Most ESR1 mutations that occur at positions 537 538 have been associated with poor clinical outcomes. potential provide neoantigens. This study aims identify if generate specific T cell responses...
In the last decade, environmental impact assessment has become a major concern for human activities, which is particularly true health. The french healthcare sector emits approximately 49 million tons of CO2 equivalent (CO2eq) per year, 8% total national Green House Gas (GHG) emissions. this context, assessing carbon footprint resource-consuming unit like cytotoxic drug production (CPU) essential. study aimed to assess CPU. A retrospective was conducted in CPU producing more than 51,000...
Several distinct innate lymphoid cell (ILC) populations have been recently identified and shown to play a critical role in the immediate immune defense. In context of tumors, there is evidence support dual for ILCs with pro- or antitumor effects, depending on ILC subset type cancer. This ambivalent has particularly well-described colorectal cancer models (CRC), but presence evolution peripheral blood metastatic CRC (mCRC) patients not yet explored. Here, we investigated distribution subsets...
Combining immunogenic cell death-inducing chemotherapies and PD-1 blockade can generate remarkable tumor responses. It is now well established that TGF-β1 signaling a major component of treatment resistance contributes to the cancer-related immunosuppressive microenvironment. However, whether remains an obstacle immune checkpoint inhibitor efficacy when immunotherapy combined with chemotherapy still be determined. Several syngeneic murine models were used investigate role neutralization on...
CD226 has been reported to participate in the rescue of CD8+ T cell dysfunction. In this study, we aimed assess prognostic value tumor-infiltrating lymphocytes (TILs) derived from colorectal cancer (CRC) liver metastases treated with chemotherapy and radical surgery. TILs 43 were isolated analyzed ex vivo using flow cytometry. CD155 CD3 levels tumor microenvironment assessed by immunohistochemistry. Exploration validation biological processes highlighted study performed bioinformatics...
Background The positive role of CD8+ tumor-infiltrating lymphocytes (TIL) in patients with colorectal cancer (CRC) has been well described but the prognostic value CD4 T cell subsets remained to be investigated. In this study, we expanded TIL from surgically resected liver metastases CRC and characterized phenotype expanded-CD4 cells. Methods Liver were 23 CRC. Tumors enzymatically digested cultured high dose interleukin-2 for up 5 weeks. reactivity cultured-T cells measured by flow...
Ibrutinib treatment has been shown to increase survival in patients with B cell malignancies. Real-life data suggest a large part of discontinuations are due toxicities, impairing ibrutinib efficacy. We aimed assess the impact pharmaceutical care program on efficacy and safety ibrutinib. This single-center, cohort, observational study enrolled Patients were either assigned or receive usual care, based physician decision. The was conducted by clinical pharmacists specializing oncology...
Objective The clinical benefit of pharmaceutical cares in improving the quality-of-care outcomes is well demonstrated. Clinical pharmacy services are not systematically deployed cancer units absence economic data. aim this prospective, observational 1-year study was to evaluate clinical, and organisational impacts care into a multidisciplinary day hospital for patients treated with oral drugs. Methods All pharmacists' interventions (PI) were documented their impact probability adverse drug...
Purpose Cancer patients are at risk of severe COVID-19 infection, and vaccination is recommended. Nevertheless, we observe a failure vaccines in this vulnerable population. We hypothesize that senescent peripheral T-cells alter vaccine-induced immunity. Methods performed monocentric prospective study enrolled cancer healthy donors before the vaccination. The primary objective was to assess association (CD28 - CD57 + KLRG1 ) with Results Eighty have been included, serological specific T-cell...
Convalescent plasma therapy has been described as an attractive approach to treat critically ill patients with COVID-19 (Coronavirus disease 2019). The selection of convalescent donors (CPD) is commonly based on neutralizing antibody titer. A better understanding the quality immune responses following will enable optimization donors' in programs. involvement SARS-CoV-2 specific T cells induction and persistence high affinity anti-SARS-CoV-2 still poorly investigated. In this study, 115 CPD...
Kidney transplant recipients (KTR) are at increased risk for COVID-19-associated complications. We aimed to describe the evolving epidemiology and outcome of PCR-documented SARS-CoV-2 infection in KTR followed our institution from March 2020 May 2022. The primary endpoint was hospitalization COVID-19-related symptoms or death within 28 days diagnosis. Overall, 243 cases were included which 68 (28%) developed outcome. A significant decrease incidence observed (p < 0.001, r -0.342) during...
Immunotherapy (IT) is a major therapeutic strategy for lymphoma, significantly improving patient prognosis. IT remains ineffective significant number of patients, however, and exposes them to specific toxicities. The identification predictive factors around efficacy toxicity would allow better targeting patients with higher ratio benefit risk. PRONOSTIM multicenter retrospective study using the Clinical Data Warehouse (CDW) Greater Paris University Hospitals network. Adult Hodgkin lymphoma...