A5027283708- Prostate Cancer Treatment and Research
- PARP inhibition in cancer therapy
- Receptor Mechanisms and Signaling
- Mass Spectrometry Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Protein Degradation and Inhibitors
- Immunotherapy and Immune Responses
- Amino Acid Enzymes and Metabolism
- CAR-T cell therapy research
- Advanced Proteomics Techniques and Applications
- CRISPR and Genetic Engineering
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Psoriasis: Treatment and Pathogenesis
- Histone Deacetylase Inhibitors Research
- Immune cells in cancer
- Epigenetics and DNA Methylation
Inserm
2018-2023
Établissement Français du Sang
2023
Université de franche-comté
2023
Université Bourgogne Franche-Comté
2018-2022
Centre Hospitalier Universitaire de Besançon
2020-2021
CD226 has been reported to participate in the rescue of CD8+ T cell dysfunction. In this study, we aimed assess prognostic value tumor-infiltrating lymphocytes (TILs) derived from colorectal cancer (CRC) liver metastases treated with chemotherapy and radical surgery. TILs 43 were isolated analyzed ex vivo using flow cytometry. CD155 CD3 levels tumor microenvironment assessed by immunohistochemistry. Exploration validation biological processes highlighted study performed bioinformatics...
Combining immunogenic cell death-inducing chemotherapies and PD-1 blockade can generate remarkable tumor responses. It is now well established that TGF-β1 signaling a major component of treatment resistance contributes to the cancer-related immunosuppressive microenvironment. However, whether remains an obstacle immune checkpoint inhibitor efficacy when immunotherapy combined with chemotherapy still be determined. Several syngeneic murine models were used investigate role neutralization on...
Abstract Androgen deprivation therapy (ADT) is the standard of care for treatment nonresectable prostate cancer. Despite high efficiency, most patients ultimately develop lethal castration-resistant cancer (CRPC). In this study, we performed a comparative proteomic analysis three in vivo, androgen receptor (AR)-responsive orthograft models matched hormone-naïve and CRPC. Differential revealed that distinct molecular mechanisms, including amino acid (AA) fatty metabolism, are involved...
Background The positive role of CD8+ tumor-infiltrating lymphocytes (TIL) in patients with colorectal cancer (CRC) has been well described but the prognostic value CD4 T cell subsets remained to be investigated. In this study, we expanded TIL from surgically resected liver metastases CRC and characterized phenotype expanded-CD4 cells. Methods Liver were 23 CRC. Tumors enzymatically digested cultured high dose interleukin-2 for up 5 weeks. reactivity cultured-T cells measured by flow...
Purpose Cancer patients are at risk of severe COVID-19 infection, and vaccination is recommended. Nevertheless, we observe a failure vaccines in this vulnerable population. We hypothesize that senescent peripheral T-cells alter vaccine-induced immunity. Methods performed monocentric prospective study enrolled cancer healthy donors before the vaccination. The primary objective was to assess association (CD28 - CD57 + KLRG1 ) with Results Eighty have been included, serological specific T-cell...
Cancer Drug Resistance is an open access journal, focusing on pharmacological aspects of drug resistance and its reversal, molecular mechanisms classes, etc. Both clinical experimental in cancer are included.
Abstract Androgen-deprivation therapy (ADT) is the standard of care for treatment non-resectable prostate cancer (PCa). Despite high efficiency, most patients ultimately develop lethal castration-resistant (CRPC). In this study, we perform a comparative proteomic analysis three in vivo, androgen receptor (AR)–driven, orthograft models CRPC. Differential reveals that distinct molecular mechanisms, including amino acid (AA) and fatty (FA) metabolism, are involved response to ADT between...
Abstract Androgen-deprivation therapy (ADT) is the standard of care for treatment non-resectable prostate cancer (PCa). Despite high efficiency, most patients ultimately develop lethal castration-resistant (CRPC). In this study, we perform a comparative proteomic analysis three in vivo, androgen receptor (AR)–driven, orthograft models CRPC. Differential reveals that distinct molecular mechanisms, including amino acid (AA) and fatty (FA) metabolism, are involved response to ADT between...
<div>Abstract<p>Androgen deprivation therapy (ADT) is the standard of care for treatment nonresectable prostate cancer. Despite high efficiency, most patients ultimately develop lethal castration-resistant cancer (CRPC). In this study, we performed a comparative proteomic analysis three <i>in vivo</i>, androgen receptor (AR)-responsive orthograft models matched hormone-naïve and CRPC. Differential revealed that distinct molecular mechanisms, including amino acid (AA)...
<p>Significantly down-reg genes in SLFN5 KO cells and tumours</p>
<p>Pathway Enrichment_RNASeq</p>
<p>ATF4_binding sites</p>
<p>Figures S1-S2-S3 + Suppl. Fig. legends Methods</p>
<p>RNASeq_SLFN5 KO</p>
<p>SLFN5_binding sites</p>
<p>ATF4_binding sites</p>
<p>RNASeq_SLFN5 KO</p>
<p>Proteomics_CRPC</p>
<p>List of antibodies</p>
<p>List of primers</p>
<p>Figures S1-S2-S3 + Suppl. Fig. legends Methods</p>
<p>Significantly down-reg genes in SLFN5 KO cells and tumours</p>
<p>List of primers</p>