A5084806299- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Autoimmune Bullous Skin Diseases
- Immunodeficiency and Autoimmune Disorders
- Renal Diseases and Glomerulopathies
- Hematopoietic Stem Cell Transplantation
- Vasculitis and related conditions
- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- T-cell and B-cell Immunology
- Viral-associated cancers and disorders
- Urticaria and Related Conditions
- Cytomegalovirus and herpesvirus research
- Blood disorders and treatments
- Immunotherapy and Immune Responses
- Eosinophilic Disorders and Syndromes
- Cancer Immunotherapy and Biomarkers
- Acute Myeloid Leukemia Research
- Sarcoidosis and Beryllium Toxicity Research
- Oral health in cancer treatment
- Neutropenia and Cancer Infections
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Hôpital Saint-Antoine
2016-2025
Centre de Recherche Saint-Antoine
2018-2025
Inserm
2018-2025
Fontbonne University
2024
Université Paris 1 Panthéon-Sorbonne
2021-2023
Center for Rheumatology
2021
Sorbonne Paris Cité
2019
Abstract This study evaluated the safety and immunogenicity of BNT162b2 vaccine in patients with hematological malignancies. Antibodies blocking spike binding to immobilized ACE-2 (NAb) correlated anti-Spike (S) IgG d42 titers (Spearman r = 0.865, p < 0.0001), an anti-S level ≥3100 UA/mL was predictive NAb ≥ 30%, positivity cutoff for ( 0.0001). Only 47% achieved after two inocula, compared 87% healthy controls. In multivariable analysis, male patients, use B-cell targeting treatment...
Objectives Systemic sclerosis (SSc) is an autoimmune disease characterised by widespread fibrosis, microangiopathy and autoantibodies. Follicular helper T (Tfh) cells CD4 + CXCR5 PD-1 cooperate with B lymphocytes to induce the differentiation of plasmocytes secreting immunoglobulins (Ig). Circulating Tfh (cTfh) are increased in several diseases. However, there no data about cTfh their interaction SSc. The aim this study was perform a quantitative functional analysis Methods Using flow...
Diagnosis of large vessel vasculitis (LVV) and evaluation its inflammatory activity can be challenging. Our aim was to investigate the value hybrid positron-emission tomography/magnetic resonance imaging (PET/MRI) in LVV. All consecutive patients with LVV from Department Internal Medicine who underwent PET/MRI were included. Three patterns defined: (i) "inflammatory," positive PET (>liver uptake) abnormal MRI (stenosis and/or wall thickening); (ii) "fibrous", negative (≤liver MRI; (iii)...
Introduction Antiphospholipid syndrome (APS) is an autoimmune disease characterised by thrombosis (arterial, venous or small vessel) obstetrical events and persistent antiphospholipid antibodies (aPL), according to the Sydney classification criteria. Many studies have performed cluster analyses among patients with primary APS associated disease, but none has focused solely on APS. We aimed perform a analysis asymptomatic aPL carriers without any assess prognostic value. Methods In this...
Objective Antiphospholipid syndrome (APS) is defined by the association of thromboembolic and/or obstetrical clinical manifestations and presence antiphospholipid antibodies. The objective our study was to evaluate impact triple-positive profile in a cohort 204 APS patients. Methods We conducted retrospective study, including patients with primary or secondary APS, meeting Sydney criteria at least one thrombotic complication. Clinical characteristics risk relapse (defined occurrence new...
Digestive tract sarcoidosis (DTS) is rare and case-series are lacking. In this retrospective case–control study, we aimed to compare the characteristics, outcome, treatment of patients with DTS, nondigestive (NDTS), Crohn disease. We included cases confirmed sarcoidosis, symptomatic digestive involvement, noncaseating granuloma in any tract. Each case was compared 2 controls sarcoidoisis without involvement 4 25 DTS 50 NDTS 100 The major clinical features were abdominal pain (56%), weight...
SSc is an autoimmune disease characterized by fibrosis, microangiopathy and immune dysfunctions including dysregulation of proinflammatory cytokines. Clonal haematopoiesis indeterminate potential (CHIP) defined the acquisition somatic mutations in haematopoietic stem cells leading to detectable clones blood. Recent data have shown a higher risk cardiovascular patients with CHIP resulting from increased production cytokines accelerated atherosclerosis. Eventual links between diseases are...
Abstract Background From this retrospective study, we aimed to (1) describe the prevalence and characteristics of non-criteria features in primary antiphospholipid syndrome (p-APS) (2) determine their prognostic value. Methods This French multicenter cohort study included all patients diagnosed with p-APS (Sydney criteria) between January 2012 2019. We used Kaplan-Meier adjusted Cox proportional hazards models compare incidence relapse without manifestations. Results One hundred seventy-nine...
Individuals with chronic lymphocytic leukemia (CLL) or small lymphoma (SLL) have a high risk of developing other malignancies (OMs). The development OMs may be associated the advanced age CLL/SLL patients, presence tumor-promoting microenvironment, immune alterations inherent to CLL/SLL, chemotherapy. Importantly, occurrence following frontline fludarabine, cyclophosphamide and rituximab (FCR) treatment is reduction in overall survival (OS). This retrospective study included 108 patients...
Daratumumab (Dara), an anti-CD38 monoclonal antibody, has immunologic mechanism of action through targeting CD38 expressing immune cells in patients with multiple myeloma (MM). Furthermore, it was recently shown that upregulation tumors, is a major acquired resistance to antiprogrammed cell death 1 (PD-1)/programmed ligand (PD-L1). Therefore, we decided evaluate the immunomodulatory effects blockade by Dara on PD-L1 cells.We analyzed and expression at different time points 18 newly diagnosed...
Summary Immune effector cell‐associated hematotoxicity (ICAHT) is a common toxicity associated with an important morbidity after chimeric antigen receptor (CAR)‐T‐cell therapy. Multiple factors seem to be involved in the development of severe ICAHT, making its management difficult. Here, we report three cases ICAHT axicabtagene‐ciloleucel (axi‐cel) for diffuse large B‐cell lymphoma showing expansion granular lymphocyte bone marrow CD3/CD57‐positive non‐CAR‐T immunophenotype. We show that it...
Arsenic trioxide (As2O3) is recently found to have therapeutic potential in systemic sclerosis (SSc), a life-threatening multi-system fibrosing autoimmune disease with type I interferon (IFN-I) signature. Chronically activated plasmacytoid dendritic cells (pDCs) are responsible for IFN-I secretion and closely related fibrosis establishment SSc. In this study, we showed that high concentrations of As2O3 induced apoptosis pDCs via mitochondrial pathway increased BAX/BCL-2 ratio, while...
Abstract Objectives Haploidentical haematopoietic cell transplantation (Haplo‐HCT) using peripheral blood stem (PBSC) grafts and post‐transplant cyclophosphamide (PTCy) is being increasingly used; however, data on immunological reconstitution (IR) are still scarce. Methods This retrospective study evaluated T‐cell in 106 adult patients who underwent allogeneic for haematologic malignancies between 2013 2016. Results At D30, while conventional T cells reached similar median counts Haplo‐HCT...