A5072729671- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer and Skin Lesions
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Male Breast Health Studies
- Breast Implant and Reconstruction
- Estrogen and related hormone effects
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Treatment and Pharmacology
- Lymphoma Diagnosis and Treatment
- Nutritional Studies and Diet
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Genetic factors in colorectal cancer
- Nutrition, Genetics, and Disease
- Pleural and Pulmonary Diseases
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Screening and Detection
- Cancer Cells and Metastasis
Guy's Hospital
2013-2025
Queen Mary University of London
2021-2023
King's College London
2009-2021
Florida College
2019-2021
University of Florida
2019-2021
Breast Center
2019
Cedars-Sinai Medical Center
2019
Regional Research Council in Uppsala-Örebro Region
2016
Philadelphia University
2016
National Health Service
2011-2013
The European Organisation for Research and Treatment of Cancer conducted a randomized trial investigating the role radiotherapy (RT) after local excision (LE) ductal carcinoma-in-situ (DCIS) breast. We analyzed efficacy RT with 10 years follow-up on both overall risk recurrence (LR) related to clinical, histologic, treatment factors.After complete LE, women DCIS were randomly assigned no further or (50 Gy). One thousand ten mostly (71%) mammographically detected included. median was 10.5...
Initial results of the UK/ANZ DCIS (UK, Australia, and New Zealand ductal carcinoma in situ) trial suggested that radiotherapy reduced new breast events ipsilateral invasive situ (DCIS) compared with no radiotherapy, but significant effects were noted tamoxifen. Here, we report long-term this trial.Women completely locally excised recruited into a randomised 2×2 factorial tamoxifen, or both. Randomisation was independently done for each two treatments (radiotherapy tamoxifen), stratified by...
In view of the increasing number patients treated with breast-conserving treatment (BCT) for ductal carcinoma-in-situ (DCIS), risk factors recurrence and metastasis should be identified.Clinical pathologic characteristics from DCIS in European Organization Research Treatment Cancer trial 10853 (excision or without radiotherapy) were related to recurrence. Pathologic features derived a central review 863 1,010 randomized cases (85%). The median follow-up was 5.4 years.Factors associated an...
Purpose Adjuvant radiotherapy (RT) after a local excision (LE) for ductal carcinoma in situ (DCIS) aims at reduction of the incidence recurrence (LR). We analyzed long-term risk on developing LR and its impact survival treatment DCIS. Patients Methods Between 1986 1996, 1,010 women with complete LE DCIS less than 5 cm were randomly assigned to no further (LE group, n = 503) or RT (LE+RT 507). The median follow-up time was 15.8 years. Results Radiotherapy reduced any by 48% (hazard ratio...
Male breast cancer (MBC) presents problems with identification of high-risk groups. Risk factors include hepatic dysfunction, high ambient working temperature, exposure to exhaust fumes and obesity, but none identify a group absolute number MBC cases. The two significant cohorts are BRCA2 mutation carriers individuals Klinefelter's syndrome (KS), responsible for up 15% Since >90% male tumours ER+ve, endocrine intervention is logical the likely agent being tamoxifen. In terms an acceptable...
To elucidate the association between stressful life events and development of cancer influence stress on relapse in operable breast was examined matched pairs women a case-control study. Adverse difficulties occurring during postoperative disease free interval were recorded 50 who had developed their first recurrence equivalent follow up times with remission. The cases controls for main physical pathological factors known to be prognostic sociodemographic variables that frequency...
SUMMARY The relationship between breast cancer (BC) and inflammation remains unclear. Some risk factors, such as age, obesity postmenopausal status, are also associated with increased levels of circulating proinflammatory cytokines systemic inflammation. role T lymphocytes during BC development has been the subject great debate, improved survival reported when CD8+ CD3+ T-lymphocytic infiltrates present. Studies B-lymphocytic prognosis have yielded conflicting results, but extent...
Detection of serum biomarkers for early diagnosis breast cancer remains an important goal. Changes in the structure O-linked glycans occur all cancers resulting expression glycoproteins that are antigenically distinct. Indeed, assay widely used monitoring disease progression (CA15.3), detects a glycoprotein (MUC1), but elevated levels antigen cannot be detected stage patients. However, since immune system acts to amplify antigenic signal, antibodies can sera long before antigen. We have...
The treatment of Paget disease by mastectomy has been challenged recently in favor breast-conserving techniques. A large series patients treated with reviewed to assess the feasibility less radical surgery.The cases 70 women a clinical diagnosis were reviewed. type, grade, receptor and node status, mammographic pathologic extent underlying breast malignancy determined. survival invasive was compared matched controls without disease.The 58% cases. Despite fact that only one third presented...
Abstract Mammographic features are known to be associated with breast cancer but the magnitude of effect differs markedly from study study. Methods assess mammographic range subjective qualitative classifications computer-automated quantitative measures. We used data UK Guernsey prospective studies examine relative value these methods in predicting risk. In all, 3,211 women ages ≥35 years who had a mammogram taken 1986 1989 were followed-up end October 2003, 111 developing during this...
Abstract The growth of human mammary epithelial cells is stimulated by cholera toxin and analogues cyclic AMP, while the breast derived fibroblasts inhibited. These compounds have little effect on DNA synthesis in absence other mitogens but show a synergistic with serum and/or EGF. results suggest that high intracellular levels AMP increase response cell to mitogens.