A5023123250- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Adrenal and Paraganglionic Tumors
- Venous Thromboembolism Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Pituitary Gland Disorders and Treatments
- Aortic Disease and Treatment Approaches
- Cancer, Hypoxia, and Metabolism
- Vascular Procedures and Complications
- Diagnosis and Treatment of Venous Diseases
- Cerebrovascular and Carotid Artery Diseases
- Hormonal Regulation and Hypertension
- Orthopedic Surgery and Rehabilitation
- Abdominal vascular conditions and treatments
- Shoulder Injury and Treatment
- Atrial Fibrillation Management and Outcomes
- Renal and Vascular Pathologies
- Acute Ischemic Stroke Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Peripheral Nerve Disorders
- Vascular Anomalies and Treatments
- Metastasis and carcinoma case studies
- Glioma Diagnosis and Treatment
- COVID-19 and healthcare impacts
University Medical Center Utrecht
2018-2025
University of Louisville
2024
Heidelberg University
2024
University Hospital Heidelberg
2024
Leiden University
2023
Utrecht University
2020-2021
Dutch Institute for Clinical Auditing
2018-2021
University of Amsterdam
2020
Society for Vascular Surgery
2020
Haga Hospital
2020
Adrenal medullary hyperplasias (AMHs) are adrenal proliferations with a size < 1 cm, while larger lesions considered as pheochromocytoma (PCC). This arbitrary distinction has been proposed decades ago, although the biological relationship between AMH and PCC never investigated. Both frequently diagnosed in multiple endocrine neoplasia type 2 (MEN2) patients whom they two unrelated clinical entities. In this study, we investigated molecular MEN2 patients. Molecular aberrations of 19 AMHs 13...
Abstract Objective Autosomal dominant variants in the succinate dehydrogenase gene (SDHx) are responsible for approximately 50% of development hereditary paragangliomas and pheochromocytomas (PPGLs). Limited research has been conducted on psychosocial impact possessing a tumor syndrome. In this study, psychological harboring genetic variant associated with familial paraganglioma syndrome was assessed. Secondary objectives included analysis potential variations quality life (pre)symptomatic...
There is a lack of comprehensive and uniform data on primary upper extremity deep venous thrombosis (pUEDVT). pUEDVT includes thoracic outlet syndrome related (UEDVT) idiopathic UEDVT. Research these conditions has been hampered by their rarity, diagnostic criteria, heterogeneity in therapeutic strategies. To improve current research collection using input all various treating medical specialists, we initiated the ThoRacic OuTlet Syndrome (TROTS) registry. The aim TROTS registry to a)...
Pheochromocytomas (PCCs) are rare tumors that arise from chromaffin tissue in the adrenal medulla, but can also occur abdomen outside adrenals and then called sympathetic paragangliomas (sPGLs). According to literature, between 15 25% of apparently sporadic PCC sPGL caused by germline mutations RET, von Hippel-Lindau disease (VHL), succinate dehydrogenase subunit B (SDHB), or D SDHD. However, few studies have addressed mutationfrequency these candidate genes selected subgroups andsPGL, such...
The Dutch guideline for patients suspected of head and neck paragangliomas (HNPGLs) recommends magnetic resonance imaging (MRI) and/or computed tomography (CT) the area. Additionally, it suggests considering additional nuclear imaging. aim this study was to evaluate outcomes [68Ga]Ga-DOTATOC PET/CT compared MRI in with HNPGLs carriers genetic variations. Methods: In single-center pilot study, retrospective data were obtained from consecutive between 2016 2023. Both performed within 12...
Pheochromocytomas (PCCs) are neuroendocrine tumors of chromaffin tissue that produce catecholamines. They usually located in the adrenal medulla, although about 10% arise from extra-adrenal tissue. The majority PCCs sporadically, but occur also context hereditary cancer syndromes. Familial PCC is inherited as an autosomal dominant trait alone or a component multiple endocrine neoplasia Type 2 (MEN2) syndrome (RET gene), Von Hippel-Lindau (VHL) disease (VHL neurofibromatosis 1 (NF1 familial...
There is a lack of comprehensive and uniform data on head neck paragangliomas (HNPGLs), research challenging due to its rarity the involvement multiple medical specialties. To improve current collection, we initiated Head Neck Paraganglioma Registry (HNPGL Registry). The aim HNPGL a) collect extensive all patients through predefined protocol, b) give insight in long term outcomes using patient reported outcome measures (PROMs), c) create uniformity diagnostic clinical management these...
Current treatment strategies for primary upper extremity deep venous thrombosis (pUEDVT) range from conservative with anticoagulation therapy to invasive thoracic outlet decompression surgery (TOD), frequently combined catheter directed thrombolysis, percutaneous transluminal angioplasty, or stenting. Due a lack of large prospective series uniform data collection randomized trial, the optimal strategy is still under debate. We conducted multicenter observational study assess efficacy and...
Introduction The low prevalence of Arterial Thoracic Outlet Syndrome (ATOS) and diffuse symptomatology have resulted in limited data on optimal treatment strategies long-term outcome. aim this study was to report evaluate a single center experience with the ATOS including midterm patient reported Methods All patients treated for from 2004 2020 were retrospectively identified. Patients divided into two groups based presenting symptoms; ATOX group (Acute arterial occlusion ischemia)...
In upper extremity thrombosis research, the occurrence of postthrombotic syndrome (UE-PTS) is commonly used as main outcome parameter. However, there currently no reporting standard or a validated method to assess UE-PTS presence and severity. recent Delphi study, consensus was reached on preliminary score, combining 5 symptoms, 3 signs, inclusion functional disability score. which score be included.The aim current study determine specific type finalize score.This project designed...
Hemodynamic disturbances cause half of the perioperative strokes following carotid endarterectomy (CEA). Guidelines strongly recommend strict pre- and postoperative blood pressure (BP) monitoring in CEA patients, but do not provide firm practical recommendations. Although Netherlands 50 centres perform CEA, no national protocol on hemodynamic, cerebral exists. To assess current policies all Dutch CEA-centres, a survey was conducted.Between May July 2017 CEA-centres were invited to complete...
Introduction: Renal artery aneurysm (RAA) is a rare vascular disease with mortality rate of up to 80% upon rupture. This study aimed investigate the safety and efficacy ex situ repair autotransplantation for endovascularly untreatable RAA. Methods: A retrospective nationwide cohort was conducted in RAA patients undergoing Netherlands. Surgical techniques, postoperative complications, graft outcomes were assessed. Results: Ex performed 9 11 RAAs. Eight RAAs located at first bifurcation, one...
Abstract Disclosure: B.J. Petri: None. B.L. Valdes: K.M. Piell: E.C. Rouchka: C.M. Klinge: Acquired resistance to endocrine therapies (ET) in patients with estrogen receptor α (ER+) breast tumors results metastatic spread. RNA modifications including N6-methyladenosine (m6A) play crucial roles the post-transcriptional regulation of gene expression and have been implicated cancer progression. We hypothesized that m6A epitranscriptomic alterations are associated pathways ET resistance....
Abstract Disclosure: B.J. Petri: None. B.L. Valdes: K.M. Piell: E.C. Rouchka: C.M. Klinge: Acquired resistance to endocrine therapies (ET) in patients with estrogen receptor α (ER+) breast tumors results metastatic spread. RNA modifications including N6-methyladenosine (m6A) play crucial roles the post-transcriptional regulation of gene expression and have been implicated cancer progression. We hypothesized that m6A epitranscriptomic alterations are associated pathways ET resistance....
Abstract Objectives Renal multiparametric MRI (mpMRI) is a promising tool to monitor renal allograft health enable timely treatment of chronic nephropathy. This study aims validate mpMRI by whole-kidney histology following transplantectomy. Materials and methods A patient with kidney transplant failure underwent prior The included blood oxygenation level-dependent (BOLD) MRI, T 1 2 mapping, diffusion-weighted imaging (DWI), 2D phase contrast (2DPC) arterial spin labeling (ASL). Parenchymal...