A5015271466- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Cancer Risks and Factors
- Reconstructive Surgery and Microvascular Techniques
- Global Cancer Incidence and Screening
- Mesenchymal stem cell research
- Body Contouring and Surgery
- Cancer Diagnosis and Treatment
- Breast Lesions and Carcinomas
- BRCA gene mutations in cancer
- Cancer, Lipids, and Metabolism
- Cardiac, Anesthesia and Surgical Outcomes
- Endometriosis Research and Treatment
- Lymphatic System and Diseases
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer and Skin Lesions
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Male Breast Health Studies
- Metabolism, Diabetes, and Cancer
- Advances in Oncology and Radiotherapy
- Cardiovascular Disease and Adiposity
- Reproductive Biology and Fertility
- Sarcoma Diagnosis and Treatment
Institut universitaire du cancer de Toulouse Oncopole
2017-2024
Institut de Pharmacologie et de Biologie Structurale
2018-2024
Centre National de la Recherche Scientifique
2018-2024
Hôpitaux Universitaires de Strasbourg
2024
Centre Hospitalier Universitaire de Toulouse
2009-2024
Université Toulouse III - Paul Sabatier
2015-2024
Université de Toulouse
2019-2024
Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
2024
Institut des Corps Gras
2023
Centre de recherche Translationnelle en Médecine moléculaire
2023
Clinical studies suggest that obesity, in addition to promoting breast cancer aggressiveness, is associated with a decrease chemotherapy efficacy, although the mechanisms involved remain elusive. As one of main treatments for aggressive or metastatic cancer, we investigated whether adipocytes can mediate resistance doxorubicin (DOX), drugs used treat and associated. We coculture system grow cells vitro differentiated as well primary mammary isolated from lean obese patients. Drug cellular...
Growing evidence indicates that adiposity is associated with breast cancer risk and negatively affects recurrence survival, a paracrine role of mammary adipose tissue being very likely in this process. In contrast to other depots, occurrence sub-inflammatory state defined by dying adipocytes surrounded macrophages forming crown-like structures overweight obese subjects, remains only partially described. general population patients (107 patients) mostly undergoing breast-conserving surgery,...
Objective— Estrogens exert beneficial effect on the blood vascular system. However, their role lymphatic system has been poorly investigated. We studied protective of 17β estradiol—the most potent endogenous estrogen—in lymphedema—a dysfunction, which results in a massive fluid and fat accumulation limb. Approach Results— Screening DNA motifs able to mobilize ERs (estrogen receptors) quantitative real-time polymerase chain reaction analysis revealed that estradiol promotes transcriptional...
Background: A few studies have examined the characteristics of severe breast cancer-related lymphedema (BCRL). This study aims at analyzing factors associated with (LE) across a specific population patients BCRL. Methods and Results: Seventy-four BCRL were included cared for in Lymphology Unit Toulouse University Hospital between 2015 2016. Characteristics related to retrospectively assessed. The median age time LE was 56 years (30–82). Thirty-five (47.3%) had mastectomy 72 (97.3%) an...
Abstract Cytotoxic therapy for breast cancer inhibits the growth of primary tumors, but promotes metastasis to sentinel lymph nodes through lymphatic system. However, effect first-line chemotherapy on endothelium has been poorly investigated. In this study, we determined that paclitaxel, anti-cancer drug approved treatment metastatic or locally advanced cancer, induces endothelial cell (LEC) autophagy increase metastases. While paclitaxel was largely efficacious in inhibiting LEC adhesion,...
Abstract Obesity is a negative prognosis factor for breast cancer. Yet, the biological mechanisms underlying this effect are still largely unknown. An emerging hypothesis that transfer of free fatty acids (FFA) between adipocytes and tumor cells might be altered under obese conditions, contributing to progression. Currently there paucity models study human mammary (M-Ads)-cancer crosstalk. As other types isolated white adipocytes, herein, we showed M-Ads die within 2–3 days by necrosis when...
Dysregulated expression of translation initiation factors has been associated with carcinogenesis, but underlying mechanisms remains to be fully understood. Here we show that eIF4H (eukaryotic factor 4H), an activator the RNA helicase eIF4A, is overexpressed in lung carcinomas and predictive response chemotherapy. In cancer cells, depletion enhances sensitization chemotherapy, decreases cell migration inhibits tumor growth vivo, association reduced mRNA encoding cell-proliferation (c-Myc,...
To determine the value of performing a risk-reducing mastectomy (RRM) in absence deleterious variant breast cancer susceptibility gene, 4 clinical situations at risk cancer. The French National College Obstetricians and Gynecologists (CNGOF) Commission Senology developed these recommendations. A policy declaration monitoring links interest was applied throughout process making Similarly, development recommendations did not benefit from any funding company marketing health product. adhered to...
Breast cancer is the most common female in world. Numerous studies have shown that risk of metastatic disease increases with tumor volume. In this context, it useful to assess whether regular practice formal breast self-examination (BSE) as opposed awareness has an impact on number cancers diagnosed, their stage, treatments used and mortality.
Based on an updated review of the international literature covering different surgical techniques and complications risk reducing mastectomies (RRM) in non-genetic context, Commission Senology College National des Gynécologues et Obstétriciens Français (CNGOF) aimed to establish guidelines be chosen their implementation. The CNGOF Senology, composed 24 experts, developed these guidelines. A policy declaration monitoring links interest was applied throughout process making recommendations....
The outcome of patients presenting with vaginal melanoma has been assessed in a large multicentric retrospective study. databases 12 French institutions were searched for primary melanomas managed between 1990 and 2007. Among the 54 recorded, 46 curative intent included clinical characteristics, treatments, detection c-KIT protein expression have studied. median age was 63.5 years (42–88). Twenty-eight classified as International Federation Gynecology Obstetrics (FIGO) stage I, five II, six...
To identify predictors for infiltrating carcinoma and lymph node involvement, before immediate breast reconstructive surgery, in patients with an initial diagnosis of extensive pure ductal situ the (DCIS).Between January 2000 December 2009, 241 DCIS preoperative biopsy had underwent mastectomy. Axillary staging (sentinel and/or axillary dissection) was performed 92% (n = 221) patients. Patients micro-invasive lesions at diagnosis, recurrence or contralateral cancer were excluded.Respectively...
Oncology involves complex care and multidisciplinary management of patients; however, misinformation ineffective communication remain problematic.The educational objective our study was to develop a new teaching method improve cancer treatment by emphasizing the link between hospitals (inpatients) their surrounding communities (outpatients).A team 22 professionals from public private institutions developed small online course (SPOC). Each offering lasted 6 weeks covered topics: individual...
Non-menopausal women with breast cancer treated chemotherapy are at intermediate risk of post-treatment amenorrhea and decreased fertility. Although they should receive appropriate information, studies until now show that this is inadequate. We investigated the proportion who received information about during pre-treatment consultation, those an oncofertility consultation to preserve their gametes. also analysed medical non-medical factors influencing transmission patients uptake...
Autologous fat grafting is commonly performed in reconstructive breast surgery but also increasingly augmentation surgery. On the international level, we are witnessing an important increased confidence for this procedure. Nevertheless, it continues to raise questions on risks of cancer. A 66-year-old patient benefited from a lipofilling improve latissimus dorsi flap reconstruction, 7 years after initial cancer management. Two later, constant pain leads reoperation. The showed major...