A5073818422- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Cervical Cancer and HPV Research
- Cardiovascular Issues in Pregnancy
- Maternal and fetal healthcare
- Gynecological conditions and treatments
- Pregnancy and preeclampsia studies
- Molecular Biology Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Gestational Trophoblastic Disease Studies
- Cancer Risks and Factors
- Pelvic floor disorders treatments
- Minimally Invasive Surgical Techniques
- Maternal and Perinatal Health Interventions
- COVID-19 Impact on Reproduction
- Renal and related cancers
- Pregnancy and Medication Impact
- Breast Cancer Treatment Studies
- Intestinal and Peritoneal Adhesions
Centre Hospitalier Universitaire de Lille
2007-2019
Hôpital Jeanne de Flandre
2008-2019
Protéomique, Réponse Inflammatoire et Spectrométrie de Masse
2013-2016
Université de Lille
1990-2016
Université Lille Nord de France
2011-2016
Inserm
1992-2016
Centre Oscar Lambret
2011-2014
Centre Hospitalier d'Arras
2009
Centre National de la Recherche Scientifique
1992-2007
Université de Sherbrooke
2007
MALDI imaging mass spectrometry represents a new analytical tool to directly provide the spatial distribution and relative abundance of proteins in tissue. Twenty-five ovary carcinomas (stages III IV) 23 benign ovaries were analyzed using MALDI-TOF MS. The biomarker with major prevalence (80%) has been fully identified MS nanoESI MS/MS after separation by RP-HPLC trypsin enzymatic digestion. This marker an m/z 9744 corresponds 84 amino acid residues from 11S proteasome activator complex,...
Here we describe a new instrument (SpiderMass) designed for in vivo and real-time analysis. In this ion production is performed remotely from the MS generated ions are transported to analyzer. Ion promoted by Resonant Infrared Laser Ablation (RIR-LA) based on highly effective excitation of O-H bonds water molecules naturally present most biological samples. The retrieved molecular patterns specific cell phenotypes benign versus cancer regions patient biopsies can be easily differentiated. We...
SUMMARY This study extends a previous and confirms that the detection of anti-P30 IgA antibodies is very helpful in diagnosis acute acquired or congenital toxoplasmosis. Moreover, we demonstrate an response can be mounted fetuses infected by Toxoplasma gondii during their inira-utcrine life as early week 23 gestation. A double-sandwich ELISA described our work was used to detect 1378 human serum samples collected from 551 patients, including 162 whose mothers had been T. pregnancy, 46...