A5084563899- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Esophageal Cancer Research and Treatment
- Brain Metastases and Treatment
- Ear and Head Tumors
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Salivary Gland Tumors Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cell death mechanisms and regulation
- Advanced Radiotherapy Techniques
- RNA Interference and Gene Delivery
- Melanoma and MAPK Pathways
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glioma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Esophageal and GI Pathology
- Peptidase Inhibition and Analysis
Institut Claudius Regaud
2013-2024
Inserm
2015-2024
Institut universitaire du cancer de Toulouse Oncopole
2014-2024
Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
2020-2024
Centre de Recherche en Cancérologie de Toulouse
2015-2024
Université Toulouse III - Paul Sabatier
2015-2023
Centre Hospitalier Universitaire de Toulouse
2012-2023
GTx (United States)
2020
Radiotherapie Groep
2016-2019
Radiation Oncology Associates
2017
A combination of immune-checkpoint inhibitors and radiation therapy (RT) represents a promising therapeutic strategy in part mediated by the abscopal effect, but clinical experience related to this remains scarce. Clinical data patterns treatment were retrospectively collected from all consecutive patients with metastatic melanoma receiving programmed-death 1 (PD-1) inhibitors. Survival data, best overall response, acute delayed toxicities (graded according Common Terminology Criteria for...
A prevalence of around 26% human papillomavirus (HPV) in head and neck squamous cell carcinoma (HNSCC) has been previously reported. HPV induced oncogenesis mainly involving E6 E7 viral oncoproteins. In some cases, DNA detected to integrate with the host genome possibly contributes carcinogenesis by affecting gene expression. We retrospectively assessed integration sites signatures 80 positive patients HNSCC, using a double capture-HPV method followed next-generation Sequencing. HPV16 90%...
Radiotherapy is the cornerstone of glioblastoma (GBM) standard treatment. However, radioresistance cancer cells leads to an inevitable recurrence. In present study, we showed that blocking α6-integrin in derived from GBM biopsy specimens cultured as neurospheres, sensitized radiation. downregulated for expression, observed a decrease cell survival after irradiation and increase radio-induced death. We also demonstrated inhibition expression affects DNA damage checkpoint repair. Indeed,...
Abstract Purpose: Debio 1143 is an oral antagonist of inhibitor apoptosis proteins, which enhances tumor response with concomitant chemoradiotherapy. Addition to cisplatin-based chemoradiotherapy in locally advanced squamous cell carcinomas the head and neck (LA-SCCHN) was evaluated a phase I/II study determine MTD recommended II dose (RP2D). Here, I results are reported. Patients Methods: Treatment-naïve patients LA-SCCHN (stages III/IVA/IVB) received (100, 200, 300 mg/day), for 14 days...
Cytochrome P450 1B1 (CYP1B1) is mostly expressed in tumours and displays unusual properties. Its two polymorphic forms were differently associated with anticancer drug sensitivity. We decipher here the role of this polymorphism efficacy vitro, vivo clinical setting.From head-and-neck squamous cell carcinoma lines not expressing CYP1B1, we generated isogenic derivatives forms. Proliferation, invasiveness, stem characteristics, sensitivity to agents transcriptome analysed. Tumour growth...
Abstract Salivary carcinomas of minor salivary glands are very infrequent tumors. When located in the tongue, therapeutic strategy may comprise upfront surgery, which be debilitating, and/or (chemo‐)radiotherapy. The aim this study was to identify prognostic factors tongue a population‐based cohort. This retrospective multicentric study, based on “Réseau d'Expertise Français sur les Cancers ORL Rares” (REFCOR), included all patients with carcinoma diagnosed between January 2009 and December...
Stereotactic body radiation therapy (SBRT) is a therapeutic option in the guidelines for liver primaries after standard strategies like surgery or thermoablation have failed. To assess its efficacy and safety, we reviewed all patients treated by SBRT hepatocellular carcinoma (HCC) over six-year period.
Introduction: Recent modifications in the epidemiology of oropharyngeal squamous cell carcinoma (OSCC) have led to increase Human papillomavirus (HPV) related metastatic head and neck cancer patients with high life expectancy even at advanced stage, low comorbidity still restricted systemic therapy opportunities. In recent era ablative therapies’ development, oligometastatic HPV OSCC are indubitably good candidates for intensified treatment. However, data outcomes after optimised management...