A5031294477- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Radiation Dose and Imaging
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Radiation Detection and Scintillator Technologies
- Radiation Effects and Dosimetry
- MRI in cancer diagnosis
- Management of metastatic bone disease
- Esophageal Cancer Research and Treatment
- Nuclear Physics and Applications
- Brain Metastases and Treatment
- Advances in Oncology and Radiotherapy
- Breast Cancer Treatment Studies
- Gastric Cancer Management and Outcomes
- Salivary Gland Tumors Diagnosis and Treatment
- Brain Tumor Detection and Classification
- Radiation Effects in Electronics
- Advanced Computing and Algorithms
- Hepatocellular Carcinoma Treatment and Prognosis
Institut Claudius Regaud
2015-2025
Institut universitaire du cancer de Toulouse Oncopole
2014-2024
Centre de Recherche en Cancérologie de Toulouse
2016-2024
Centre National de la Recherche Scientifique
2017-2023
Inserm
2016-2023
Université Toulouse III - Paul Sabatier
2016-2021
Université de Toulouse
2021
Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
2019
The Maria Sklodowska-Curie National Research Institute of Oncology
2016-2019
Medical University of Warsaw
2019
To integrate 3D MR spectroscopy imaging (MRSI) in the treatment planning system (TPS) for glioblastoma dose painting to guide simultaneous integrated boost (SIB) intensity-modulated radiation therapy (IMRT). For sixteen patients, we have simulated three types of dosimetry plans, one conventional plan 60-Gy conformational radiotherapy (3D-CRT), IMRT and 72-Gy SIB-IMRT. All MRSI metabolic maps were into TPS, using normalization with color-space conversion threshold-based segmentation. The...
In this work we use EBT3 film measurements at 10 MV to demonstrate the suitability of Exradin W1 (plastic scintillator) for relative dosimetry within small photon fields. We then measure field correction factors required by two other detectors: PTW unshielded Ediode 60017 and microDiamond 60019. consider on-axis correction-factors fields collimated using MLCs four different TrueBeam energies: 6 FFF, MV, FFF MV. also investigate percentage depth dose lateral profile perturbations. addition...
Abstract Background Glioblastoma (GBM) systematically recurs after a standard 60 Gy radio-chemotherapy regimen. Since magnetic resonance spectroscopic imaging (MRSI) has been shown to predict the site of relapse, we analyzed effect MRSI-guided dose escalation on overall survival (OS) patients with newly diagnosed GBM. Methods In this multicentric prospective phase III trial, who had undergone biopsy or surgery for GBM were randomly assigned (SD) high (HD) an additional simultaneous...
Glioblastoma, a high-grade glial infiltrating tumor, is the most frequent malignant brain tumor in adults and carries dismal prognosis. External beam radiotherapy (EBRT) increases overall survival but this still low due to local relapses, mostly occurring irradiation field. As ratio of spectra choline/N acetyl aspartate> 2 (CNR2) on MR spectroscopic imaging has been described as predictive for site relapse, we hypothesized that dose escalation these regions would increase control hence...
To demonstrate the feasibility of characterising MLCs and MLC models implemented in TPSs using a common set dynamic beams. A tests containing synchronous (SG) asynchronous sweeping gaps (aSG) was distributed among twenty-five participating centres. Doses were measured with Farmer-type ion chamber computed TPSs, which provided dosimetric characterisation leaf tip, tongue-and-groove, transmission each MLC, as well an assessment model TPS. Five types four evaluated, covering most frequent...
Abstract The dosimetric leaf gap (DLG) and tongue‐and‐groove (T&G) effects are critical aspects in the modeling of multileaf collimators (MLC) treatment planning system (TPS). In this study, we investigated impact limitations associated with T&G stereotactic plans its relationship need for tuning DLG Eclipse TPS. Measurements were carried out using Varian TrueBeam STx systems from two different institutions. Test fields presenting MLC patterns several sizes (meanGap) amounts effect...
Adequate modelling of the multi-leaf collimator (MLC) by treatment planning systems (TPS) is essential for accurate dose calculations in intensity-modulated radiation-therapy. For this reason modern TPSs incorporate MLC characteristics such as leaf end curvature, transmission and tongue-and-groove. However, tongue-and-groove often neglected during TPS commissioning it not known how is. This study evaluates dosimetric consequences effect two different models using both film dosimetry...
The method implemented in Monte Carlo (MC) algorithm to convert dose-to-medium (D m) dose-to-water w) is usually based on the Bragg-Gray cavity theory. Acuros XB (AXB) reports also D m and w but calculate energy deposition cross sections for water place of those local media. For both algorithms, calculation non-water media similar dose received a small volume water, enough not disturb fluence charged particles. Recently, two new methods revised theory, one proposed by Andreo other Reynaert...
The determination of output factors in small field dosimetry is a crucial point, especially when implementing stereotactic radiotherapy (SRT). Herein, working group the French medical physicist society (SFPM) was created to collect factors. objective gather and disseminate information on based different detectors for various clinical SRT equipment measurement configurations. Participants were surveyed about their equipment, including type linear particle accelerator (linac), collimator...
Purpose To investigate (i) the dosimetric leaf gap (DLG) and effect of “trailing distance” between leaves from different multileaf collimator (MLC) layers in Halcyon systems (ii) ability currently available treatment planning (TPSs) to approximate this effect. Methods DICOM plans with transmission beams sweeping tests were created Python for measuring DLG each MLC layer independently both combined. In clinical are interchangeably used offset, thus forming a trailing pattern. characterize...
Commercial TPSs typically model the tongue-and-groove (TG) by extending projections of leaf sides a certain constant width. However, this may produce discrepancies as much 7%-10% in calculated average doses, especially for High Definition multi-leaf collimator (MLC) (Hernandez et al 2017 Phys. Med. Biol. 62 6688-707). The purpose present study is to introduce and validate new method modelling TG that uses non We provide theoretical background detailed methodology determine optimal shape...
The current phase III EORTC 1420 Best-of trial (NCT02984410) compares the swallowing function after transoral surgery versus intensity modulated radiotherapy (RT) in patients with early-stage carcinoma of oropharynx, supraglottis and hypopharynx. We report analysis Benchmark Case (BC) procedures before patient recruitment special attention to dysphagia/aspiration related structures (DARS). Submitted RT volumes plans from participating centers were analyzed compared against gold-standard...
This paper is an investigation of the dosimetric performances new PTW T31022 PinPoint 3D which supersedes T31016. Measurements have been performed in small and large fields conditions, with (WFF) without flattening filter (FFF) for two energies. The study includes characterization ion collection efficiency (Jaffé plots), polarity effect measurements beam profiles, depth dose curves output factors associated to field correction factors. Jaffé plots were found be more linear than those T31016...
To evaluate and compare dosimetric parameters of volumetric modulated arctherapy (VMAT) helical tomotherapy (HT) for non-anaplastic thyroid cancer adjuvant radiotherapy.Twelve patients with at high risk local relapse received external beam radiotherapy curative intent in our institution, using a two-dose level prescription simultaneous integrated boost approach. Each patient was re-planned by the same physicist twice both VMAT HT. Several quality indexes were used: target coverage index...