A5080288716- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Advances in Oncology and Radiotherapy
- Radiomics and Machine Learning in Medical Imaging
- Radiation Effects and Dosimetry
- Sarcoma Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Prostate Cancer Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Lymphoma Diagnosis and Treatment
- Advanced Condensed Matter Physics
- Physics of Superconductivity and Magnetism
- Management of metastatic bone disease
- Cancer, Hypoxia, and Metabolism
- Vascular Tumors and Angiosarcomas
- Breast Cancer Treatment Studies
- Cardiac Imaging and Diagnostics
- Cutaneous lymphoproliferative disorders research
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Colorectal and Anal Carcinomas
- Radiation Dose and Imaging
Rambam Health Care Campus
2012-2024
IRCCS Humanitas Research Hospital
2017
Provincia Autonoma di Trento
2016
Centre Lasers Intenses et Applications
2013
Technion – Israel Institute of Technology
1989-2010
Brown University
1994
Roger Williams Medical Center
1994
Abstract Radiation therapy, in conjunction with surgical implant fixation, is a common combined treatment cases of bone metastases. However, metal implants generally used orthopedic perturb radiation dose distributions. Carbon‐Fiber Reinforced Polyetheretherketone (CFR‐PEEK) material has been recently introduced for production intramedullary nails and plates. The purpose this work was to investigate the perturbation effects new CFR‐PEEK screws on radiotherapy distributions evaluate these...
Background The European Organization for Research and Treatment of Cancer 22092‐62092 STRASS trial failed to demonstrate the superiority neoadjuvant radiotherapy (RT) over surgery alone in patients with retroperitoneal sarcoma. Therefore, an RT quality‐assurance program was added study protocol detect correct deviations. authors report results from its potential effect on patient outcomes. Methods To evaluate compliance survival outcomes, a composite end point created. It combined...
The following is a report on the clinical experience of an Israeli referral center for iodine-131 metaiodobenzylguanidine (131-MIBG) therapy malignant pheochromocytoma (MPCC) and paraganglioma (MPGG). charts 10 patients with MPCC (n = 7) MPGG 3) treated between 2000 2008 were reviewed. Response to 131-MIBG was evaluated by tumor, hormone, symptomatic relief criteria. median follow-up 18 months (2-48 months). number treatments ranged from 1 4 (mean: 2.1). average single dose 5.4 +/- 0.2 GBq...
To demonstrate the feasibility of characterising MLCs and MLC models implemented in TPSs using a common set dynamic beams. A tests containing synchronous (SG) asynchronous sweeping gaps (aSG) was distributed among twenty-five participating centres. Doses were measured with Farmer-type ion chamber computed TPSs, which provided dosimetric characterisation leaf tip, tongue-and-groove, transmission each MLC, as well an assessment model TPS. Five types four evaluated, covering most frequent...
The purpose of this study was to evaluate the feasibility hippocampal-sparing whole-brain radiotherapy (HS WBRT) using Elekta Infinity linear accelerator and Monaco treatment planning system (TPS). Ten plans were created for HS-WBRT a dose 30 Gy (10 fractions). RTOG 0933 recommendations applied planning. Intensity-modulated (IMRT) 3.1 TPS-based on nine-field arrangement step-and-shoot delivery method. Plan evaluation performed D2% D98% PTV (defined as whole brain excluding hippocampus...
This work demonstrates the safety and feasibility of Lattice Radiotherapy (LRT) for large soft tissue sarcoma in neoadjuvant radiotherapy. The treatment consisted two courses: LRT course with a single fraction 20 Gy delivered to high dose nuclei (HDN) regions conventional 25 fractions 2 planning target volume. HDN shaped as cylinders 1 cm diameter height were placed within gross tumour number HDNs their position determined based on tumor size proximity organs at risk. Three patients...
This study evaluated the results of postoperative adjuvant radiotherapy in patients with localized renal cell carcinoma (RCC).Eighty-six (median age, 60 years) RCC treated by radical nephrectomy were for efficacy radiotherapy. Twenty-four percent had stage T2, 35% T3a, 36% T3b and 5% T4 disease. Seventy-seven clear carcinomas 23% granular or spindle mixed carcinomas. Radiotherapy was given to bed adjacent lymphatic basin at a median dose 46 Gy.Thirty-two (37%) relapsed: 27 (84%) systemic...
Dosimetry of small fields defined by stereotactic cones remains a challenging task. In this work, we report the results commissioning measurements for new Elekta conical collimator system attached to VersaHD linac and present comparison between measured Monte Carlo (MC) calculated data 6 MV FFF beam. addition, relative output factor (ROF) dependence on cone aperture variation was studied penumbra MLC-based cone-based performed.Cones with nominal diameters 15 mm, 12.5 10 7.5 5 mm were...
Abstract Background Ventricular tachycardia (VT) is a life-threatening arrhythmia originating from the heart’s ventricles. Traditional treatments include antiarrhythmic medications, implantable cardioverter-defibrillators (ICDs), and catheter ablation. Stereotactic body radiation therapy (SBRT) targeting arrhythmogenic focus in left ventricle—stereotactic radioablation (STAR)—is an emerging treatment may offer potential solution for patients with refractory VT. Objective We designed...
Abstract The clinical characteristics of 240 patients with sarcoma as a second metachronous primary neoplasm (SPN) were compared those 8,815 single tumor. data obtained from registered during the period 1973–1986 in Surveillance, Epidemiology and End Results (SEER) Program United States. Seventy‐four SPN had postirradiation (PIS) while other 153 developed tumor an area which was not exposed to prior radiotherapy (non‐PIS). stage disease at diagnosis more advanced PIS than sarcomas but...
The wedge factor (WF) for an x‐ray beam is defined as the ratio of doses with and without at a point on central axis, in water. It function depth d , field size s collimator setting c . demonstrated that WF can be calculated WF( )=WF air A w ( ) H )/ 0 ), where constant factor, namely, incident fluences measured “in air” reference conditions, e.g., isocenter 10×10 cm 2 setting. are attenuation factors, head‐scatter normalized to conditions. This expression based approximation scatter same...
The design concept and dosimetric characteristics of a new applicator system for intraoperative radiation therapy (IORT) are presented in this work. A hard-docking commercial includes polymethylmethacrylate (PMMA) applicators with different diameters end angles set secondary lead collimators. telescopic device allows changing source-to-surface distance (SSD). All measurements were performed 6, 9, 12 18 MeV electron energies. Output factors percentage depth doses (PDD) measured water phantom...
Abstract Purpose Total Skin Electron Irradiation (TSEI) is a complex technique which usually involves the use of large electron fields and dual‐field approach. In this situation, many electrons scattered from treatment room floor are produced. However, no investigations effect in TSEI treatments have been reported. The purpose work was to study contribution skin dose during using Monte Carlo (MC) simulations. Methods All MC simulations were performed with EGSnrc code. Influence beam energy,...
Total skin electron irradiation (TSEI) is a complex technique which requires many nonstandard measurements and dosimetric procedures. The purpose of this work was to validate measured dosimetry data by Monte Carlo (MC) simulations using EGSnrc‐based codes (BEAMnrc DOSXYZnrc). Our MC consisted two major steps. In the first step, incident beam parameters (energy spectrum, FWHM, mean angular spread) were adjusted match (PDD profile) at for an open field. second these used calculate dose...
High-resolution Auger electron spectra of ${\mathrm{La}}_{1.85}$${\mathrm{Sr}}_{0.15}$${\mathrm{CuO}}_{4}$ and ${\mathrm{La}}_{1.85}$${\mathrm{Ba}}_{0.15}$${\mathrm{CuO}}_{4}$ have been measured. The experimental line shapes the oxygen KLL copper ${\mathit{L}}_{2,3}$VV transitions are compared with those generated from local-density-approximation linear-muffin-tin-orbital band-structure calculations. An analysis based on this comparison is used to determine Coulomb parameters...