A5034646112- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Women's cancer prevention and management
- Lung Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Advanced Breast Cancer Therapies
- Gastrointestinal Tumor Research and Treatment
- Cancer survivorship and care
- Lung Cancer Treatments and Mutations
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- BRCA gene mutations in cancer
- Cervical Cancer and HPV Research
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
- Medical Imaging Techniques and Applications
- Multiple and Secondary Primary Cancers
- HER2/EGFR in Cancer Research
- Lung Cancer Research Studies
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
Eastern Cooperative Oncology Group
2016-2023
European Organisation for Research and Treatment of Cancer
2020-2022
Hospital de Clínicas de Porto Alegre
2017-2019
AC Camargo Hospital
2017-2019
Hospital Araújo Jorge
2019
Instituto Nacional do Câncer
2017-2019
Hospital Moinhos de Vento
2019
Instituto Nacional de Enfermedades Neoplásicas
2018-2019
Tecnológico de Monterrey
2018-2019
Instituto Nacional de Cancerología
2018-2019
The association between quality of surgery and overall survival in patients affected by localized gastrointestinal stromal tumors (GIST) is not completely understood.To assess the risk death with without imatinib according to microscopic margins status (R0/R1) using data from a randomized study on adjuvant imatinib.This post hoc observational included randomized, open-label, phase III trial, performed December 2004 October 2008. Median follow-up was 9.1 years (IQR, 8-10 years). at 112...
Identify the main changes in health-related quality of life (HRQoL) women diagnosed with breast cancer (BC) undergoing chemotherapy.Prospective cohort study that included 33 clinical stages I-III BC and who underwent adjuvant chemotherapy. HRQoL was assessed using EORTC QLQ-C30 QLQ-BR23 instruments 1 week before start chemotherapy during third month chemotherapy.There a decline scores patients treatment. Therefore, alters patient's perceptions their since there is decrease global health...
Breast cancer (BC) in young women is uncommon and tends to present with more aggressive characteristics. To better understand characterize this scenario Brazil through real-world data, we performed a subanalysis of AMAZONA III study (ClinicalTrials.gov identifier: NCT02663973).The (GBECAM 0115) prospective registry that included 2,950 newly diagnosed invasive BC from January 2016 until March 2018 at 22 sites. Valid data were obtained 2,888 patients regarding age diagnosis complete baseline...
Background The European Organization for Research and Treatment of Cancer 22092‐62092 STRASS trial failed to demonstrate the superiority neoadjuvant radiotherapy (RT) over surgery alone in patients with retroperitoneal sarcoma. Therefore, an RT quality‐assurance program was added study protocol detect correct deviations. authors report results from its potential effect on patient outcomes. Methods To evaluate compliance survival outcomes, a composite end point created. It combined...
The present study aims to assess the performance of 18F-FDG PET-CT on mediastinal staging non-small cell lung cancer (NSCLC) in a location with endemic granulomatous infectious disease.Diagnostic test including patients aged 18 years or older operable stage I-III NSCLC and indication for lymph node biopsy. All underwent PET-scan before invasive staging, either through mediastinoscopy thoracotomy, which was considered gold-standard. Surgeons pathologists were blinded scan results. Primary...
Testosterone suppression is the standard treatment for advanced prostate cancer, and it associated with side-effects that impair patients' quality of life, like sexual dysfunction, osteoporosis, weight gain, increased cardiovascular risk. We hypothesized abiraterone acetate prednisone (AAP) apalutamide, alone or in combination, can be an effective hormonal therapy also possibly decreasing castration-associated side effects.Phase II, open-label, randomized, efficacy trial plus Androgen...
Mutations in the ESR1 gene (ESR1m) are important mechanisms of resistance to endocrine therapy estrogen receptor-positive advanced breast cancer and have been recognized as a prognostic predictive biomarker well potential therapeutic target. However, prevalence ESR1m real-world patients has not adequately described. Therefore, we sought evaluate metastatic samples from Brazilian with (ER+) previously treated therapy. The presence was evaluated formalin-fixed paraffin-embedded (FFPE) tissue...
Cervical cancer is the fourth most common in women worldwide. Epidemiological and quality of life (QoL) data patients with cervical from low- middle-income countries are scarce. We aimed to describe sociodemographic clinicopathological characteristics at diagnosis Brazil.EVITA a prospective cohort study newly diagnosed May 2016 December 2017, stages I-IVB, 16 Brazilian sites representing five regions. At baseline, medical evaluation was performed European Organization for Research Treatment...
Of newly diagnosed patients with non-small-cell lung cancer (NSCLC), stage III accounts for 30%. Most are treated concurrent chemoradiation therapy, but the addition of consolidation chemotherapy (CC) is debatable. We examined effect CC in Brazilian NSCLC routine clinical practice.We retrospectively collected data from five different institutions who had and were therapy followed or not by CC. Eligible age 18 years older must have been cisplatin-carboplatin plus etoposide, paclitaxel,...
99mTc-EDDA/HYNIC-TOC is an easily available and cheaper radionuclide that could be used for somatostatin-receptor-based imaging of neuroendocrine tumours (NETs). We aimed to evaluate the diagnostic performance compared to111In-DTPA-octreotide in patients (pts) with NETs. performed a prospective study including pts biopsy-confirmed NET at least one visible lesion conventional imaging. Two independent nuclear medicine physicians evaluated who underwent 99mTc 111In scans images. The primary...
Abstract Background Randomised clinical trials (RCT) are considered a gold standard generating efficacy and safety data supporting drug approval. However, real world (RWD) reflecting health care delivery is becoming increasingly important. RWD on patient profiles patterns of in MBC scarce developing countries. As an example, observational studies suggest that despite guideline recommendations clearly indicating ET for hormone receptor positive MBC, considerable proportion patients practice...
11566 Background: The EORTC 22092-62092 STRASS trial failed to detect a superiority of neoadjuvant radiotherapy in patients with retroperitoneal sarcoma as compared surgery alone. As (RT) was the experimental treatment, comprehensive quality assurance program (RTQA) has been included study protocol order and correct potential RT deviations. We report here overall RTQA results its impact on patient’s outcomes this international phase III trial. Methods: Plans from all randomized preoperative...
O uso e a disponibilidade da internet suscitam questões sobre seu potencial mobilizador de dependência. Este artigo discute Uso Internet por estudantes universitários brasileiros. Com base em uma coleta dados quantitativa (n=173), o estudo concluiu que 61,85% dos participantes apresentam níveis dependência Leve Moderado. A frequência do falta controle tempo conectado indicam valorização vida virtual possíveis prejuízos na rotina. Ainda os não sejam considerados graves, resultados deste...
Abstract Background: Breast cancer (BC) with low expression of HER2 (HER2-low) might constitute a group tumors unique clinical and biological characteristics. However, the prognostic impact HER2-low status vs HER2-zero in terms pathological complete response (pCR) event-free survival (EFS) after neoadjuvant chemotherapy (NACT) remains controversial. The aim this study was to evaluate pCR EFS rates early BC patients treated NACT. Methods: In cross-sectional study, we analyzed 565 consecutive...
Abstract Background: Breast cancer (BC) with low expression of HER2 (HER2-low) might constitute a group tumors unique clinical and biological characteristics. Little is known about axillary downstaging nodal surgical outcomes in HER2-low BC after neoadjuvant chemotherapy (NACT). The aim this study was to evaluate response management the axilla patients submitted NACT. Methods: In cross-sectional single center study, we consecutively included all diagnosed early HER2-negative between 2017...
e21140 Background: Immune checkpoint inhibitors improved outcomes of patients with advanced non-small cell lung cancer (NSCLC). KEYNOTE-024 trial demonstrated that immunotherapy was superior to platinum-based chemotherapy in the first-line setting. However, only 30% screened had programmed death receptor ligand-1 (PD-L1) expression above 50%. The prevalence biomarkers NSCLC may vary through different regions worldwide. Our study aims describe PD-L1 Brazil. Methods: Immunohistochemistry for...