A5039241159- Advanced MRI Techniques and Applications
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Traumatic Brain Injury Research
- MRI in cancer diagnosis
- Radiation Dose and Imaging
- Glioma Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Quantum Mechanics and Applications
- Radiation Detection and Scintillator Technologies
- Atomic and Subatomic Physics Research
- Cardiovascular Function and Risk Factors
- NMR spectroscopy and applications
- Quantum Information and Cryptography
- Advanced NMR Techniques and Applications
- Advanced X-ray Imaging Techniques
- Mitochondrial Function and Pathology
- Cardiac Imaging and Diagnostics
- Suicide and Self-Harm Studies
- Lanthanide and Transition Metal Complexes
University of Manchester
2018-2023
Manchester Academic Health Science Centre
2023
The Christie NHS Foundation Trust
2018-2023
Cardiff University
2019-2021
Brigham and Women's Hospital
2015-2019
Harvard University
2017-2019
Cancer Research UK Manchester Institute
2019
Institut universitaire du cancer de Toulouse Oncopole
2015
Institut Claudius Regaud
2014
In this work we use EBT3 film measurements at 10 MV to demonstrate the suitability of Exradin W1 (plastic scintillator) for relative dosimetry within small photon fields. We then measure field correction factors required by two other detectors: PTW unshielded Ediode 60017 and microDiamond 60019. consider on-axis correction-factors fields collimated using MLCs four different TrueBeam energies: 6 FFF, MV, FFF MV. also investigate percentage depth dose lateral profile perturbations. addition...
Isocitrate dehydrogenase (IDH) mutations result in abnormal accumulation of 2-hydroxyglutarate (2HG) gliomas that can be detected by MRS. We examined the diagnostic accuracy 2HG single-voxel spectroscopy (SVS) and chemical shift imaging (CSI) both newly diagnosed posttreatment settings. Long echo time (97 ms) SVS CSI were acquired 85 subjects, including a discovery cohort 39 patients who had postoperative residual or recurrent glioma with confirmed IDH-mutation status 6 normal volunteers,...
Averaging multiple repetitions to improve signal-to-noise ratio is common practice in magnetic resonance spectroscopy (MRS). However, temporal variations scanner B0 due motion or gradient heating may cause spectra become misaligned, broadening and distorting peaks impacting on processing quantification. We present a comparison using vivo data of different methods for correcting these errors.Three correction were applied 53 brain scans: residual water peak alignment, creatine fitting,...
Purpose The design and performance of a novel head coil setup for P spectroscopy at ultra‐high field strengths (7T) is presented. described system supports measurements both the H resonance frequencies. Methods consists 2, actively detunable, coaxial birdcage coils to give homogeneous transmit, combined with double resonant 30 channel receive array. This allows anatomical imaging acquisitions over whole head, without changing or disturbing subject. A phosphate buffer phantom 3 healthy...
MR spectroscopy (MRS) typically requires averaging of multiple acquisitions to achieve adequate signal-to-noise ratio (SNR). In systems undergoing dynamic changes this can compromise the temporal resolution measurement. One such example is (31) P MRS exercising skeletal muscle. Spectral improvement by Fourier thresholding (SIFT) offers a way suppressing noise without averaging. study, we evaluate performance SIFT in healthy subjects and clinical cases.(31) calf or thigh muscle (n = 12) was...
For cancers such as glioblastoma multiforme, there is an increasing interest in defining "biological target volumes" (BTV), high tumour-burden regions which may be targeted with dose boosts radiotherapy. The definition of a BTV requires insight into tumour characteristics going beyond conventionally defined radiological abnormalities and anatomical features. Molecular biochemical imaging techniques, like positron emission tomography, the use Magnetic Resonance (MR) Imaging contrast agents or...
Contact sports athletes, military personnel, and civilians that suffer from multiple head traumas have the potential to develop Chronic Traumatic Encephalopathy (CTE), a progressive, degenerative brain disease diagnosed only postmortem by characteristic tau deposition in brain. There is, therefore, need for in-vivo diagnosis CTE diagnose manage this disease, while individual is still alive. However, there no definitive because of heterogeneous clinical symptoms often overlap with other...
Purpose MR spectroscopy of dynamic systems is limited by low signal to noise. Denoising along a series acquired spectra exploits their temporal correlation improve the quality individual spectra, and reduce errors in fitting metabolite peaks. In this study we compare performance several denoising methods. Methods Six different methods were considered: SIFT (Spectral Improvement Fourier Thresholding), HSVD (Hankel Singular Value Decomposition), spline, wavelet, sliding window Gaussian....
Post-Traumatic Stress Disorder (PTSD) and mild Traumatic Brain Injury (mTBI) affect soldiers returning from recent conflicts at an elevated rate. Our study focuses on the use of magnetic resonance spectroscopy (MRS) measurements to distinguish subjects having mTBI, PTSD, or both, with goal identifying biomarkers for these specific disorders MRS data. provides a non-invasive in vivo technique measuring concentration metabolites brain, thus serving as "virtual biopsy" that can be used monitor...
MR-guided radiotherapy has different requirements for the images than diagnostic radiology, thus requiring development of novel imaging sequences. MRI simulation is an excellent tool optimizing these new sequences; however, currently available software does not provide all necessary features. In this paper, we present a digital framework testing sequences that incorporates anatomical structure, respiratory motion, and realistic presentation MR physics.