A5031947064- Nutrition and Health in Aging
- Clinical Nutrition and Gastroenterology
- Frailty in Older Adults
- Cancer survivorship and care
- Health, Medicine and Society
- Colorectal Cancer Treatments and Studies
- Head and Neck Cancer Studies
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Healthcare Systems and Practices
- Oral health in cancer treatment
- Nutritional Studies and Diet
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Dysphagia Assessment and Management
- Diet and metabolism studies
- Cancer Treatment and Pharmacology
- Childhood Cancer Survivors' Quality of Life
- Palliative Care and End-of-Life Issues
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Anorectal Disease Treatments and Outcomes
Université de Montpellier
2012-2025
Institut de Recherche en Cancérologie de Montpellier
2015-2025
Inserm
1996-2023
Institut Universitaire de Recherche Clinique
2016-2023
Institut Regional du Cancer de Montpellier
2014-2021
Dynamique des Capacités Humaines et des Conduites de Santé
2015-2020
CEA Valduc
2007-2019
Université Paul-Valéry Montpellier
2018-2019
Centre Occitanie-Montpellier
1999-2018
Unité de Nutrition Humaine
2018
Purpose Existing definitions of clinically important weight loss (WL) in patients with cancer are unclear and heterogeneous do not consider current trends toward obesity. Methods Canadian European (n = 8,160) formed a population-based data set. Body mass index (BMI) percent WL (%WL) were recorded, observed prospectively until death. Data entered into multivariable analysis controlling for age, sex, site, stage, performance status. Relationships BMI %WL to overall survival examined develop...
This epidemiological observational study aimed at determining the prevalence of malnutrition in non-selected adults with cancer, to identify risk factors and correlate results length stay 2-month mortality. prospective multicentre 1-day conducted 17 French Comprehensive Cancer Centres included 1545 patients. Body mass index (BMI), weight loss (WL) past 6 months age were routinely recorded according national recommendations for hospitalised patients; was rated as absent, moderate or severe...
Abstract Evidence suggests that lean body mass (LBM) may be useful to normalize chemotherapy doses. Data from one prospective and retrospective study were used determine if the highest doses of oxaliplatin/kg LBM within FOLFOX regimens would associated with dose‐limiting toxicity (DLT) in colon cancer patients. Toxicity over four cycles was graded according NCI Common Criteria V2 or V3 (Common Terminology for Adverse Events, National Cancer Institute, Bethesda, MD). Muscle tissue measured by...
Objective We tested the effect of dietary advice dedicated to increase intake in older patients at risk for malnutrition during chemotherapy, versus usual care, on one-year mortality. Method conducted a multicentre, open-label interventional, stratified (centre), parallel randomised controlled trial, with 1∶1 ratio, two-year follow-up. Patients were aged 70 years or treated chemotherapy solid tumour and (MNA, Mini Nutritional Assessment 17–23.5). Intervention consisted diet counselling aim...
Patients with breast cancer undergoing chemotherapy and radiotherapy experience fatigue other treatment side effects. Integrative therapies combining physical activity dietary counseling are recommended; however to date no large randomized controlled trial has been conducted during adjuvant therapy. The Adapted Physical Activity Diet (APAD) intervention was evaluated for its ability decrease (primary outcome), anxiety, depression, body mass index (BMI), fat mass, enhance muscular cognitive...
Overweight/obese patients' large fat mass can mask the loss of skeletal muscle, which is associated with mortality in oncology setting. We investigated prevalence computed tomography (CT)-defined sarcopenia and myosteatosis across different levels nutrition risk assessed by Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF). also evaluated whether PG-SGA SF, sarcopenia, were prognostic overall survival.This was a prospective, observational study. Consecutive patients body...
Abstract Background Cancer‐associated weight loss (WL) associates with increased mortality. International consensus suggests that WL is driven by a variable combination of reduced food intake and/or altered metabolism, the latter often represented inflammatory biomarker C‐reactive protein (CRP). We aggregated data from Canadian and European research studies to evaluate associations CRP cancer‐associated (primary endpoint) overall survival (OS, secondary endpoint). Methods The set included...
Abstract Little is known about the precise relationship between energy intake, overweight, sedentary lifestyle, and steps in colorectal adenoma-carcinoma pathway. We studied these parameters within a case-control study. Patients with adenomas <10 mm (n = 154) or >10 208) were compared polyp-free controls 426) for determining factors associated adenoma formation, i.e., observed small large adenomas, growth only. Colorectal cancer cases 171) population 309) to determine specific final stage,...
A case-control study in the Côte d'Or area of France used multistep concept colorectal carcinogenesis to compare lifetime tobacco consumption and present alcohol patients with small adenomas (less than 1 cm, n = 154) or large (n 208) polyp-free controls 427). Cancer 171) were compared population 309). In men, smoking was associated risk (odds ratio 3.6 over 20 pack-years vs. nonsmokers, p < 0.001). Alcohol a factor for only, relative risks 4.2 (p 0.01), 3.0 0.05), 4.4 0.01) consumptions...
Background and study aims: Differential diagnosis between pancreatic adenocarcinoma (PADC) pseudotumoral forms of chronic pancreatitis remains difficult. Mutation KRAS oncogene is present in 75 % to 95 PADC. This aimed evaluate whether the combined analysis mutation with cytopathological findings from endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) might improve discrimination PADC pancreatitis.
Background: Chemoradiotherapy (CRT) for head and neck cancer (HNC) induces side-effects, including trismus, which impairs quality of life by causing difficulty to eat, speak, maintain good oral hygiene, altering social life. Given the wide variation reported trismus prevalence as a first mandatory step preventive physiotherapy OPEN program (NCT03979924) this study evaluated occurrence its link with radiation doses. Methods: Study population was non-larynx HNC patients epidermoid carcinoma...
Purpose of review Recent recommendations on cachexia highlight, in head and neck cancers, the heterogeneity studies, focusing weight loss sequelae including swallowing disorders. The current national guidelines emphasize that, cases concurrent chemoradiotherapy (cCRT) involving oral cavity oropharynx, prophylactic gastrostomy placement should be carried out systematically. We why this technique is particularly relevant specific location for feasibility cCRT. findings A randomized trial...
In the monocentric APAD1 trial, 143 women with non-metastatic breast cancer were randomised to undergo either an adapted physical activity and diet counselling (APAD) program or usual care. Health-related quality of life (HRQoL) was prospectively evaluated using EORTC QLQ-C30 questionnaire at baseline, during treatment (adjuvant chemotherapy radiotherapy) follow-up. Our objective two-fold: analyse impact APAD on HRQoL three approaches; illustrate advantages disadvantages each approach,...
Although the high meat–low vegetable diet is considered reference high-risk for colorectal cancer, particularly in USA communities, other at-risk dietary patterns, such as intakes of processed meat and refined carbohydrates are emerging. Little known about risk factors cancer France, a country at rectal moderately colon cancer. We compared cases (n = 171) general population controls 309) Burgundy (France). Categories intake were established by sex based on distributions food controls. Odds...
Abstract: Several hypotheses have been proposed for colorectal carcinogenesis, including formation of free radicals. A case-control study compared nutrient intake in 171 cancer cases versus 309 general population controls, using a detailed face-to-face food history questionnaire. composition table enabled us to determine the mean diet macro- and micronutrients. Dietary intakes were separately categorized into quartiles by gender. Logistic regression models adjusted age, sex, energy,...
PURPOSE: This prospective, nonrandomized study evaluates, with a seven-year median follow-up, the morbidity and functional oncologic results of conservative surgery after high-dose radiation for cancer lower third rectum patients who would otherwise have undergone abdominoperineal resection. METHODS: Between June 1990 1996, 43 distal rectal adenocarcinoma were treated by preoperative radiotherapy (40 + 20 Gy delivered three fields) curative surgery. The mean distance from anal verge was 50...
To assess the clinical characteristics and outcome of patients with liver metastases in prostate carcinoma.From January 1995 to December 2005, 345 metastatic cancer were prospectively recorded database Montpellier Cancer Centre, France. The 28 who developed during course disease analysed.Six had as first site disease, for one them, was only site. All but patient hormone-refractory disease. Serum measurement neuroendocrine markers showed increased levels chromogranin A neurone-specific...