A5101652866- Hypothalamic control of reproductive hormones
- Fibroblast Growth Factor Research
- Plant Physiology and Cultivation Studies
- Proteoglycans and glycosaminoglycans research
- Regulation of Appetite and Obesity
- Horticultural and Viticultural Research
- Growth Hormone and Insulin-like Growth Factors
- Cardiac, Anesthesia and Surgical Outcomes
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Forest, Soil, and Plant Ecology in China
- Connective tissue disorders research
- Plant Pathogens and Fungal Diseases
- Flowering Plant Growth and Cultivation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Wnt/β-catenin signaling in development and cancer
- Pluripotent Stem Cells Research
- Banana Cultivation and Research
- Anesthesia and Pain Management
- Protease and Inhibitor Mechanisms
- Plant tissue culture and regeneration
- Vascular Malformations Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Neuropeptides and Animal Physiology
- Immune Response and Inflammation
Nanjing Medical University
2015-2024
Jiangsu Province Hospital
2015-2024
The Royal Free Hospital
2003-2015
University College London
2003-2015
Roland Hill (United Kingdom)
2003-2005
Xinqiao Hospital
2000
Army Medical University
2000
Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny. Here, we report functional interaction between the FGFR1-FGF2-heparan sulfate complex, leading amplified responses in FGFR1 signaling pathway. In embryonic GnRH neuroblasts, wild-type anosmin-1, but not proteins with loss-of-function KS mutations, induces neurite outgrowth...
Activation of fibroblast growth factor (FGF) signaling is initiated by a multiprotein complex formation between FGF, FGF receptor (FGFR), and heparan sulfate proteoglycan on the cell membrane. Cross-talk with other factors could affect this assembly modulate biological response cells to FGF. We have previously demonstrated that anosmin-1, glycosylated extracellular matrix protein, interacts FGFR1 enhances its activity in an IIIc isoform-specific HS-dependent manner. The molecular mechanism...
Defective function of anosmin-1, the protein encoded by KAL-1, underlies X-linked Kallmann's syndrome (X-KS), a human hereditary developmental disorder. Anosmin-1 appears to play role in neurite outgrowth and axon branching, although molecular mechanisms its action are still unknown. contains WAP (whey acidic protein-like) domain four contiguous FnIII (fibronectin-like type III) repeats; shows similarity known serine protease inhibitors, whereas domains contain HS (heparan sulphate)-binding...
GnRH-I and its receptor (GnRHR-I) have previously been demonstrated shown to be biologically active in the immune system, notably within peripheral lymphocytes. Recently however, a second form of GnRH (GnRH-II) has described human. The functions both these neuropeptides PMBCs not understood yet. present study was therefore designed investigate effects and/or GnRH-II on human PMBC proliferation males. Secondly, IL-2 dependent lymphocyte were examined. Finally, we analysed role IL-2R...
KAL1 is implicated in 5% of Kallmann syndrome cases, a disorder which genotypically overlaps with septo-optic dysplasia (SOD). To date, reporter-based assay to assess the functional consequences mutations lacking. We aimed develop luciferase for novel application assessment rare detected screen 422 patients SOD. Quantitative analysis was performed using L6-myoblasts stably expressing FGFR1, transfected luciferase-reporter vector containing elements FGF-responsive osteocalcin promoter. The...
BACKGROUND Intraoperative persistent hypotension (IPH) during pancreaticoduodenectomy (PD) is linked to adverse postoperative outcomes, yet its risk factors remain unclear. AIM To clarify the associated with IPH PD, ensuring patient safety in perioperative period. METHODS A retrospective analysis of records from January 2018 December 2022 at First Affiliated Hospital Nanjing Medical University identified PD. These included age, gender, body mass index, American Society Anesthesiologists...
ISHS XXVIII International Horticultural Congress on Science and Horticulture for People (IHC2010): III Symposium Plant Genetic Resources GENETIC DIVERSITY IN LITCHI AND LONGAN GERMPLASM AS DETERMINED BY SRAP MARKERS
Abstract Background Postoperative nausea and vomiting (PONV) as a clinically most common postoperative complication requires multimodal antiemetic medications targeting at wide range of neurotransmitter pathways. Lacking neurobiological mechanism makes this ‘big little problem’ still unresolved. We aim to investigate whether gut-vagus-brain reflex generally considered one four typical emetic neuronal pathways might be the primary mediator PONV. Methods Three thousand two hundred twenty-three...
ISHS XXVIII International Horticultural Congress on Science and Horticulture for People (IHC2010): III Symposium Plant Genetic Resources GENETIC DIVERSITY OF GERMPLASM RESOURCES LITCHI AND LONGAN USING SSR ANALYSIS
BACKGROUND:Trigeminocardiac reflex (TCR) is a unique brain stem that manifests as the sudden onset of hemodynamic perturbation in heart rate and blood pressure result stimulation any branches trigeminal nerve. Onyx™ embolization cerebrovascular interventional surgery can trigger TCR, leading to severe fluctuations even cardiac arrest. Appropriate prophylactic approaches prevent embolization-induced TCR are still lacking. CASE REPORT:We report cases 2 patients with recurrent profound...