A5011433007- Glaucoma and retinal disorders
- COVID-19 Clinical Research Studies
- Retinal Imaging and Analysis
- Lung Cancer Research Studies
- Sepsis Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Retinal Diseases and Treatments
- Long-Term Effects of COVID-19
- Lung Cancer Treatments and Mutations
- Acute Kidney Injury Research
- Stroke Rehabilitation and Recovery
- Hip disorders and treatments
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Hemodynamic Monitoring and Therapy
- Head and Neck Cancer Studies
- Neuroblastoma Research and Treatments
- Genetic factors in colorectal cancer
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Ischemic Stroke Management
- Neuroendocrine Tumor Research Advances
- Reliability and Agreement in Measurement
CHU Dijon Bourgogne
2013-2025
Inserm
2016-2025
Université de Bourgogne
2015-2025
National Higher School of Statistics and Applied Economy
2024
Centre d’Investigation Clinique 1436
2016-2024
Institut de Mathématiques de Bordeaux
2024
Institut de Mathématiques de Bourgogne
2024
École Nationale Supérieure de Statistique et d'Économie Appliquée
2024
Centre National de la Recherche Scientifique
2024
Clinical Investigation Center Plurithematic Tours
2015-2022
Acute kidney injury is the most frequent complication in patients with septic shock and an independent risk factor for death. Although renal-replacement therapy standard of care severe acute injury, ideal time initiation remains controversial. In a multicenter, randomized, controlled trial, we assigned early-stage who had at failure stage risk, failure, loss, end-stage disease (RIFLE) classification system but without life-threatening complications related to receive either within 12 hours...
We undertook this analysis of KRAS mutation in four trials adjuvant chemotherapy (ACT) versus observation (OBS) to clarify the prognostic/predictive roles non-small-cell lung cancer (NSCLC).KRAS was determined blinded fashion. Exploratory analyses were performed characterize relationships between status and subtype survival outcomes using a multivariable Cox model.Among 1,543 patients (763 OBS, 780 ACT), 300 had mutations (codon 12, n = 275; codon 13, 24; 14, 1). In OBS patients, there no...
Abstract Objective. Hepatocellular carcinoma (HCC) is a highly vascularized tumor in which neoangiogenesis contributes to growth and metastasis. We assessed the safety, efficacy, potential biomarkers of activity bevacizumab patients with advanced HCC. Methods. In this phase II trial, eligible received bevacizumab, 5 mg/kg or 10 every 2 weeks. The disease-control rate at 16 weeks (16W-DCR) was primary endpoint. Circulating endothelial cells (CECs) plasma cytokines angiogenic factors (CAFs)...
Multiple endocrine neoplasia syndrome type 1 (MEN1), which is secondary to mutation of the MEN1 gene, a rare autosomal-dominant disease that predisposes carriers tumors. Although genotype-phenotype studies have so far failed identify any statistical correlations, some families harbor recurrent tumor patterns. The function MENIN unclear, but has been described through discovery its interacting partners. Mutations in domains functional partners shown directly alter regulation abilities. We...
Abstract Background Although immune modulation is a promising therapeutic avenue in coronavirus disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has peculiar characteristics and outcomes, suggesting unique immunopathogenesis. Methods Thirty-six immunocompetent non-COVID-19 27 patients with severe pneumonia were prospectively enrolled single center, requiring intensive care. Clinical biological (including T cell phenotype function plasma concentrations of 30...
Purpose To identify patterns summarizing the retinal vascular network in elderly and to investigate relationship of these with cardiovascular history. Methods We conducted a population-based study, Montrachet study (Maculopathy Optic Nerve nuTRition neurovAsCular HEarT diseases), participants older than 75 years. The history disease score-based estimation their 10-year risk mortality (Heart SCORE) were collected. Retinal analysis was performed by means Singapore "I" Vessel Assessment (SIVA)...
Tumor angiogenesis in childhood neuroblastoma is an important prognostic factor suggesting a potential role for antiangiogenic agents the treatment of high-risk disease. Within KidsCancerKinome project, we evaluated new oral selective pan-VEGFR tyrosine kinase inhibitor axitinib (AG-013736) against cell lines and subcutaneous orthotopic xenograft model IGR-N91 derived from primary bone marrow metastasis. Axitinib reduced proliferation dose-dependent manner with IC(50) doses between 274...
Objectives: Increasing evidence has suggested the benefits of dexmedetomidine in patients with sepsis. Dexmedetomidine may increase vasopressor sensitivity, which be interest setting refractory septic shock. The α2 Agonist for REfractory Septic Shock (ADRESS) pilot study aimed to evaluate effect on response Design: This was a multicenter, randomized, placebo-controlled, double-blind trial. Setting: conducted 5 ICUs France. Patients: Inclusion criteria were shock (Sepsis-3 definition) and...
To compare automated and semiautomated methods for the measurement of retinal microvascular biomarkers: vascular morphology (AutoMorph) algorithm Singapore "I" Vessel Assessment (SIVA) software. Analysis fundus photographs centered on optic discs from population-based Montrachet Study adults aged 75 years older. Comparison agreement evaluation with intraclass correlation coefficients (ICCs) between SIVA AutoMorph measures central venular arteriolar equivalent, arteriolar-venular ratio,...
MEN1, which is secondary to the mutation of MEN1 gene, a rare autosomal-dominant disease that predisposes carriers endocrine tumors. Most studies demonstrated absence direct genotype-phenotype correlations. The existence higher risk death in Groupe d'étude des Tumeurs Endocrines-cohort associated with JunD interacting domain suggests heterogeneity across families expressivity. This study aims assess modifying genetic factors by estimating intrafamilial correlations and heritability six main...
Do assisted reproductive technologies (ART) and in vitro embryo culture influence the epigenetic control of imprinted genes (IGs) transposable elements (TEs) children?Significant differences DNA methylation IGs or transposon families were reported between ART naturally conceived children, but there was no difference media.There is concern that may play a role increasing incidence adverse health outcomes probably through mechanisms. It crucial to assess control, especially following...
Background. Although an isolated anti–hepatitis B virus (HBV) core antibody (anti-HBc) serological profile is frequent in human immunodeficiency (HIV)–infected patients, data on HBV vaccination these patients are scarce.
Abstract Background Non-tunneled hemodialysis catheters are currently used for critically ill patients with acute kidney injury requiring extracorporeal renal replacement therapy. Strategies to prevent catheter dysfunction and infection locks remain controversial. Methods In a multicenter, randomized, controlled, double-blind trial, we compared two strategies locking of non-tunneled catheters, namely trisodium citrate at 4% (intervention group) versus unfractionated heparin (control group),...
The Mini Mental State Examination and Montreal Cognitive Assessment are commonly used as short screening batteries for assessing cognitive impairment after stroke. However, aphasia or hemispatial neglect may interfere with the results. For this reason, we developed scale Stroke Patients (CASP), which takes these conditions into consideration previously demonstrated its superiority over scales in terms of feasibility.Our goal was to verify psychometric properties (original) French version...
ABSTRACT Septic shock is the primary cause of death in intensive care units, with about 20% patients dying first 3 days. To design future trials focused on early mortality, we require knowledge indicators that can detect at high risk from refractory septic shock. The aim this study was to assess whether cumulative dose vasopressors (CDV), calculated as epinephrine + norepinephrine, a predictor (within 72 h) attributable (EDASS). This substudy EPISS trial based 370 admitted French ICU for...