A5029959687- Bipolar Disorder and Treatment
- Cannabis and Cannabinoid Research
- Endometriosis Research and Treatment
- BRCA gene mutations in cancer
- Tryptophan and brain disorders
- Psychology and Mental Health
- Treatment of Major Depression
- Impact of Technology on Adolescents
- Prenatal Substance Exposure Effects
- Youth, Drugs, and Violence
- Occupational Health and Burnout
- Schizophrenia research and treatment
- Crystallization and Solubility Studies
- Chemical synthesis and alkaloids
- Neurotransmitter Receptor Influence on Behavior
- Psychedelics and Drug Studies
- Forensic Toxicology and Drug Analysis
- Family and Disability Support Research
- Health, Medicine and Society
- Electrolyte and hormonal disorders
- Evasion and Academic Success Factors
- Crystallography and molecular interactions
- X-ray Diffraction in Crystallography
- Infant Development and Preterm Care
- Opioid Use Disorder Treatment
Hôpital Necker-Enfants Malades
2019-2025
Mayo Clinic
2023-2025
Assistance Publique – Hôpitaux de Paris
2022-2025
Fondazione Toscana Gabriele Monasterio
2016-2024
WinnMed
2022-2024
Mayo Clinic in Arizona
2024
Mayo Clinic Health System
2022-2023
Hôpital Antoine-Béclère
2022
Yale University
2022
Université Paris Cité
2022
Background: There is evidence that vulnerability to depression and anxiety disorders markedly increased by traumatic life events. While childhood abuse has been reported be associated with poorer outcomes in bipolar disorder, little known about the neurobiological basis underlying this association. The aim of study was ascertain whether patients who were exposed a event or events (TE) have lower brain‐derived neurotrophic factor (BDNF) levels more severe psychopathology as indicated...
Primary Ovarian Insufficiency (POI), a public health problem, affects 1-3.7% of women under 40 yielding infertility and shorter lifespan. Most causes are unknown. Recently, genetic were identified, mostly in single families. We studied an unprecedented large cohort POI to unravel its molecular pathophysiology.375 patients with 70 families using targeted (88 genes) or whole exome sequencing pathogenic/likely-pathogenic variant selection. Mitomycin-induced chromosome breakages patients'...
Turner syndrome (TS; ORPHA 881) is a rare condition in which all or part of one X chromosome absent from some cells. It affects approximately every 1/2500 liveborn girls. The most frequently observed karyotypes are 45,X (40-50%) and the 45,X/46,XX mosaic karyotype (15-25%). Karyotypes with an isochromosome (45,X/46,isoXq 45,X/46,isoXp), Y chromosome, ring deletions less frequent. objective French National Diagnosis Care Protocol (PNDS; Protocole de Diagnostic et Soins) to provide health...
Objective: To assess the impact of anxiety comorbidity on quality life patients with bipolar disorder (BD). Methods: We undertook a cross-Sectional survey 162 BD outpatients interviewed Structured Clinical Interview for DSM-IV. The primary outcome measure was life, assessed 26-item WHO Quality Life Instrument (WHOQOL-BREF). Results: Anxiety in associated lower scores all domains life. psychological domain WHOQOL-BREF kept, even when current level depression added to model as confounding...
Abstract Background The current development of gynecology services for children and adolescents seeks to meet needs both in the overall population patients with rare diseases. In France, referral center gynecological diseases specializes four major types conditions, namely, uterovaginal malformations, hereditary hemorrhagic diseases, benign breast repercussions chronic Objective To describe consecutive who had a first visit 2018–2023 at Necker Pediatric University Hospital Paris, were...
Mobile phone applications (MPAs) for substance use disorder (SUD) treatment are increasingly used by patients. Although pilot studies have shown promising results, multiple previous systematic reviews noted insufficient evidence MPA in SUD treatment-many of the previously published evaluated different trials. Subsequently, we aimed to conduct an umbrella review investigating efficacy MPAs treatment, excluding nicotine/tobacco because been done this population and approach often differs from...
We report the clinical presentation and genetic screening of a 31-year-old man with dilatation aortic root ascending aorta positive family history for dissection sudden death. A novel heterozygous variant in splice acceptor site (c.1600-1G>T) TGFβR2 gene was identified by using targeted multi-gene panel analysis. Bioinformatics tools predicted that c.1600-1G>T is pathogenic altering at - 1 position affecting pre-mRNA splicing. These data confirm diverging splicing TGF-β pathway genes may be...
The spreading of video games by adolescents and young adults is increasingly leading to the development forms addiction, such as addiction internet games.The aim this work detect risk on a sample teenagers - who were asked complete an online test. interest was also possible correlations with factors coping strategies resilience interviewees.130 people, including adults, given ad hoc questionnaire game RSA (Resilience Scale for Adults) measurement resilience, COPE-NVI (Coping Orientation...
Objective To examine associations among substance use disorder (SUD) and measures of length stay (LOS) non‐psychiatric medical comorbidity (MEDCO) in older‐adult inpatients with serious mental illness (SMI), hypothesizing SUD would be related to worse clinical outcomes. Methods A cross‐sectional study analyzed records from 2010 2016 7258 SMI ≥ age 50, obtained a 274‐bed psychiatric hospital. Descriptive analyses examined prevalence rates for status (+/−), individual drug classes, total...