A5047553528- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Spinal Dysraphism and Malformations
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Facial Trauma and Fracture Management
- Fetal and Pediatric Neurological Disorders
- Spinal Fractures and Fixation Techniques
- Childhood Cancer Survivors' Quality of Life
- Meningioma and schwannoma management
- Congenital Anomalies and Fetal Surgery
- Teratomas and Epidermoid Cysts
- Congenital Diaphragmatic Hernia Studies
- Shoulder and Clavicle Injuries
- Obstructive Sleep Apnea Research
- Cervical and Thoracic Myelopathy
- Traumatic Brain Injury and Neurovascular Disturbances
- Ophthalmology and Eye Disorders
- Neuroblastoma Research and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- dental development and anomalies
- Genetic Neurodegenerative Diseases
- Neuroscience of respiration and sleep
Assistance Publique – Hôpitaux de Paris
2016-2025
Hôpital Necker-Enfants Malades
2016-2025
Université Paris Cité
2013-2024
Générale de Santé
2016-2024
Sorbonne Paris Cité
2015-2024
Université de Montpellier
2013-2024
Institut de Génomique Fonctionnelle
2013-2024
Inserm
2013-2024
Hôpital Gui de Chauliac
2024
Centre National de la Recherche Scientifique
2024
Object To date, experience of globus pallidus internus (GPi) deep brain stimulation (DBS) in the treatment Huntington's disease (HD) has been limited to a small number case reports. The aim this study was analyze long-term motor outcome cohort HD patients treated with GPi DBS. Methods Seven pharmacologically resistant chorea and functional impairment were included prospective open-label from 2008 2011. main measure section Unified Disease Rating Scale. primary end point reduction chorea....
Sleep‐disordered breathing is a common feature in children with achondroplasia. The aim of our study was to review the poly(somno)graphic (P(S)G) findings and consequent treatments achondroplasia followed national reference center for skeletal dysplasia. A retrospective clinical charts P(S)G 43 consecutive (mean age 3.9 ± 3.5 years) seen over period 2 years performed. Twenty four (59%) had obstructive sleep apnea (OSA). Thirteen an apnea‐hypopnea index (OAHI) < 5/hr, OAHI between 5 10/hr,...
Abstract Background Chiari malformation type 1 (CM1) is a rare condition where agreed classification and treatment are still missing. The goal of this study to achieve consensus on the diagnosis CM1 in children. Methods A multidisciplinary panel formulated 57 provisional statements based review literature. Thirty-four international experts (IE) participated Delphi by independently rating each statement 4-point Likert scale (“strongly disagree,” “disagree,” “agree,” “strongly agree”)....
OBJECTIVE Craniosynostoses are an underrecognized cause of intracranial hypertension (ICH), especially when associated with congenital syndromes. Alagille syndrome (ALGS) is a multisystem disorder typical facial features and hepatobiliary, cardiac, vascular, skeletal, ocular manifestations. The occurrence craniosynostosis in ALGS rare can be chronic ICH, requiring craniofacial surgery to increase the volume. authors report series 6 patients discuss their neurosurgical management. METHODS...
Abstract Background The current development of gynecology services for children and adolescents seeks to meet needs both in the overall population patients with rare diseases. In France, referral center gynecological diseases specializes four major types conditions, namely, uterovaginal malformations, hereditary hemorrhagic diseases, benign breast repercussions chronic Objective To describe consecutive who had a first visit 2018–2023 at Necker Pediatric University Hospital Paris, were...
Abstract The craniocervical junction (CCJ) forms the bridge between skull and spine, a highly mobile group of joints that allows mobility head in every direction. CCJ plays major role protecting inferior brainstem (bulb) spinal cord, therefore also requiring some stability. Children are subjected to multiple constitutive or acquired diseases involving CCJ: primary bone such as FGFR ‐related craniosynostoses conditions congenital torticollis, cervical spine luxation, neurological disorders....
Object. Malignant gliomas consist of both heterogeneous proliferating and migrating cell subpopulations, with glioma cells exhibiting less sensitivity to antiproliferative or proapoptotic drugs than proliferative cells. Therefore, the authors combined cimetidine, an antiinflammatory agent already proven act against epithelial cancer cells, temozolomide determine whether combination induces antitumor activities in experimental orthotopic human compared effects alone. Methods. Cimetidine added...
Background: Frontofacial monobloc advancement creates a communication between the anterior cranial fossa and nasal cavities. To tackle this issue, transorbital pericranial pedicled flaps are routinely performed in authors’ center. This study aimed to assess postoperative ossification of skull base following frontofacial advancement, identify factors influencing ossification. Methods: Measurements only ossified together with were on computed tomographic scans at nasofrontal nasoethmoid...
Abstract Context Endocrine complications are common in pediatric brain tumor patients. Objective We aimed to describe the endocrine follow-up of patients with primary tumors. Methods This is a noninterventional observational study based on data collection from medical records 221 followed at Pediatric Endocrinology Department. Results Median age diagnosis was 6.7 years (range, 0-15.9), median (0.3-26.6), 48.9% female. Main types were medulloblastoma (37.6%), craniopharyngioma (29.0%), and...
Abstract Mucopolysaccharidosis type I-H (MPS I-H) is a rare lysosomal storage disorder caused by α-L-Iduronidase deficiency. Early haematopoietic stem cell transplantation (HSCT) the sole available therapeutic option to preserve neurocognitive functions. We report long-term follow-up (median 9 years, interquartile range 8–16.5) for 51 MPS patients who underwent HSCT between 1986 and 2018 in France. 4 died from complications of one disease progression. Complete chimerism normal activity were...
Among non-syndromic, single-suture craniosynostoses, unicoronal craniosynostosis (UCS) presents the highest rate of ophthalmic manifestations requiring a visual follow-up, due to high risk amblyopia. After birth or during childhood, children with UCS have present an aniso-astigmatism and strabismus. The aim this study was characterize clinical ophthalmologic findings associated in paediatric cohort.This retrospective included admitted our unit between 2015 2021, isolated treated institution...
OBJECTIVE Guidelines for the management of pediatric severe traumatic brain injury (TBI) recommend external ventricular drainage CSF as a first-tier treatment in intracranial pressure (ICP) pathway. However, ventriculostomy children can sometimes be challenging because small size lateral ventricles. External lumbar (ELD) may useful alternative; therefore, authors analyzed outcome cohort patients who underwent ELD to manage hypertension (ICH). METHODS This study retrospectively enrolled with...
Khonsari, Roman H. M.D., Ph.D.; Hennocq, Quentin M.D.; Nysjö, Johan Sandy, Ronak D.D.S.; Haber, Samer James, Syril Britto, Jonathan A. Paternoster, Giovanna Arnaud, Éric M.D.Author Information