A5043392406- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Traumatic Brain Injury Research
- Receptor Mechanisms and Signaling
- Craniofacial Disorders and Treatments
- Renal and Vascular Pathologies
- Cleft Lip and Palate Research
- Vascular Malformations Diagnosis and Treatment
- Ion Transport and Channel Regulation
- Airway Management and Intubation Techniques
- Trauma Management and Diagnosis
- Intracranial Aneurysms: Treatment and Complications
- Head and Neck Surgical Oncology
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- Hormonal Regulation and Hypertension
- Respiratory Support and Mechanisms
- Electrolyte and hormonal disorders
- Neurosurgical Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Sinusitis and nasal conditions
- Nosocomial Infections in ICU
- Neonatal Respiratory Health Research
- Injury Epidemiology and Prevention
Université Paris Cité
2015-2025
Hôpital Necker-Enfants Malades
2016-2025
Hôpital Beau-Séjour
2016-2024
Délégation Paris 5
2009-2024
Intensive Care Foundation
2024
Assistance Publique – Hôpitaux de Paris
2009-2022
Digestive Care (United States)
2022
Sorbonne Paris Cité
2014-2021
Institut Necker Enfants Malades
2001-2021
FHU Neurovasc
2021
Hypothermia therapy improves survival and the neurologic outcome in animal models of traumatic brain injury. However, effect hypothermia on mortality among children who have severe injury is unknown.In a multicenter, international trial, we randomly assigned with to either (32.5 degrees C for 24 hours) initiated within 8 hours after or normothermia (37.0 C). The primary was proportion had an unfavorable (i.e., disability, persistent vegetative state, death), as assessed basis Pediatric...
Premature menopause, also termed premature ovarian failure (POF), is characterized by cessation of menstruation before the age 40 years. Little information available on general prevalence POF or ethnic group. There a lack association with health indicators.A cross-sectional survey women aged 40-55 years was conducted at seven sites in USA to determine eligibility for community-based, multi-ethnic longitudinal study peri-menopause (The Study Women Across Nation, SWAN). Interview data were...
<h3>Abstract</h3> <b>Objective</b> To determine the effects over one year of contacting patients by telephone month or three months after being discharged from an emergency department for deliberate self poisoning compared with usual treatment. <b>Design</b> Multicentre, randomised controlled trial. <b>Setting</b> 13 departments in north France. <b>Participants</b> 605 people attempted suicide poisoning. <b>Intervention</b> The intervention consisted at discharge to evaluate success...
Choroid plexus tumors are rare intraventricular (1% of all intracranial tumors) that occur mainly in children. The pathophysiological characteristics associated hydrocephalus, surgical management, and oncological issues related to these remain a matter debate. To understand more about tumors, the authors have reviewed their experience with management 38 children choroid tumors.There were 25 cases papilloma 13 carcinoma. mean age patients at presentation was 22.5 months, one-half younger than...
Twenty-two consecutive patients with high-grade, B-cell lymphomas related to the acquired immunodeficiency syndrome (AIDS) were accrued onto two sequential phase II studies, consisting of a standard regimen (M-BACOD, group no. 1, N = 13), or novel, intensive (group 2, 9), which included high-dose cytosine arabinoside (HD-Ara-C), and methotrexate (HD-MTX), in an attempt prevent CNS relapse improve response rates. Stage IV disease was present 82%. Complete remission (CR) achieved seven 13...
To describe the results of an integrated pre- and in-hospital approach to critical care in a large population children with severe traumatic brain injury identify early predictors their outcome.A 9-yr retrospective review data trauma bank.Level III pediatric center.All (1 month 15 yrs) (Glasgow Coma Scale </=8) hospitalized our center followed until death or for >/=6 months after discharge.None.Univariate further multivariate analyses were performed determine independent predictive factors...
In order to determine whether the morphological modifications observed in arterial media of spontaneously hypertensive rats (SHR) could be induced by an abnormal response smooth muscle cells vasoactive agents, we studied action angiotensin (Ang) II on cultured aortic from both SHR and Wistar-Kyoto (WKY). Under our experimental conditions, Ang exerts a mitogenic cells, whereas its effect is very weak WKY cells. Phospholipase C activation c-fos c-myc proto-oncogene expressions are considerably...
Childhood intracerebral hemorrhage is mainly attributable to underlying brain arteriovenous malformations (bAVMs). Multimodal treatment options for bAVMs include microsurgery and embolization, allowing an immediate cure, radiosurgery, entailing longer obliteration times. Follow-up data on pediatric ruptured are scarce, making it difficult assess the risk of subsequent hemorrhage. Our aim was clinical angiographic outcome analyze factors rebleeding during after combined bAVMs.A prospectively...
A digitalis-like compound was detected in human plasma by tritiated ouabain competition binding to the sodium pump. The study comprised analyses of extracts from 17 normal controls, normotensive subjects with one or both parents hypertensive, and 16 patients untreated essential hypertension. In two thirds hypertensive several a family history hypertension potency compound, as measured its interference binding, significantly greater than controls. correlated urinary output. Measurement this...
Traumatic brain injury is a public health problem around the world, and recognition of systemic sources secondary lesions crucial to improve outcome.To identify main predictors mortality propose grading scale measure risk death.This retrospective study was based on medical records children with severe traumatic who were hospitalized at level I pediatric trauma center between January 2000 December 2005. Multiple logistic regression analysis done independent factors related mortality. A...
To describe the differences in goals for their usual practice various medical therapies from a number of international centers children with severe traumatic brain injury.