A5075279140- Gut microbiota and health
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Digestive system and related health
- Adipokines, Inflammation, and Metabolic Diseases
- Dietary Effects on Health
- Probiotics and Fermented Foods
- Oral microbiology and periodontitis research
- Diabetes and associated disorders
- Alcohol Consumption and Health Effects
- Tryptophan and brain disorders
- Infant Health and Development
- Food composition and properties
- Biochemical Analysis and Sensing Techniques
- Enhanced Recovery After Surgery
- Diabetes Management and Research
- Microbial Metabolites in Food Biotechnology
- Diet, Metabolism, and Disease
- Clusterin in disease pathology
- Metabolism and Genetic Disorders
- Regulation of Appetite and Obesity
- Genomics, phytochemicals, and oxidative stress
- Clostridium difficile and Clostridium perfringens research
- PARP inhibition in cancer therapy
- Pancreatic function and diabetes
Institut des Maladies Métaboliques et Cardiovasculaires
2011-2015
Université Toulouse III - Paul Sabatier
2009-2015
Inserm
2008-2015
Université de Toulouse
2011-2013
Hôpital Rangueil
2010
Centre Hospitalier Universitaire de Toulouse
2008
Institut National de la Recherche Agronomique
2007
Département Génétique Animale
2006
Diabetes and obesity are two metabolic diseases characterized by insulin resistance a low-grade inflammation. Seeking an inflammatory factor causative of the onset resistance, obesity, diabetes, we have identified bacterial lipopolysaccharide (LPS) as triggering factor. We found that normal endotoxemia increased or decreased during fed fasted state, respectively, on nutritional basis 4-week high-fat diet chronically plasma LPS concentration to three times, threshold defined endotoxemia....
Research Article3 August 2011Open Access Intestinal mucosal adherence and translocation of commensal bacteria at the early onset type 2 diabetes: molecular mechanisms probiotic treatment Jacques Amar Corresponding Author [email protected] Rangueil Hospital, Department Therapeutics, Toulouse, France Institut National de la Santé et Recherche Médicale (INSERM), U558, These authors contributed equally to this work. Search for more papers by author Chantal Chabo U1048, sur les Maladies...
Aim We recently described a human blood microbiome and connection between this the onset of diabetes. The aim current study was to assess association microbiota incident cardiovascular disease. Methods Results D.E.S.I.R. is longitudinal with primary describing natural history metabolic syndrome its complications. Participants were evaluated at inclusion 3-, 6-, 9-yearly follow-up visits. 16S ribosomal DNA bacterial gene sequence, that common vast majority bacteria (Eubac) sequence mostly...
Abstract Pattern recognition receptors link metabolite and bacteria‐derived inflammation to insulin resistance during obesity. We demonstrate that NOD 2 detection of bacterial cell wall peptidoglycan ( PGN ) regulates metabolic sensitivity. An obesity‐promoting high‐fat diet HFD increased in hepatocytes adipocytes, −/− mice have adipose tissue liver exacerbated a . This effect is independent altered adiposity or hematopoietic‐derived immune cells. Instead, associated with commensal...
Ingested glucose is detected by specialized sensors in the enteric/hepatoportal vein, which send neural signals to brain, turn regulates key peripheral tissues. Hence, impairment control of enteric-neural sensing could contribute disordered homeostasis. The aim this study was determine cells brain targeted activation enteric glucose-sensing system.We selectively activated axis mice using a low-rate intragastric infusion wild-type and glucagon-like peptide-1 (GLP-1) receptor knockout mice,...
Depuis quelques recentes annees, la flore intestinale se positionne en tant que regulateur du metabolisme energetique a part entiere. Les liens fonctionnels qui unissent l’intestin et l’ensemble des microorganismes vivants le peuplent (microbiote) sont resultante d’une symbiose etroite. Ainsi, une ecologie mutualisee entre les bacteries l’hote confere chaque partie un avantage concurrentiel notamment vis-a-vis agressions d’origine exterieure. A naissance, est colonise par micro-organismes...