A5028324712- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Eosinophilic Disorders and Syndromes
- Cardiac and Coronary Surgery Techniques
- Chronic Myeloid Leukemia Treatments
- PI3K/AKT/mTOR signaling in cancer
- Melanoma and MAPK Pathways
- Obstructive Sleep Apnea Research
- Hemodynamic Monitoring and Therapy
- Surgical Simulation and Training
- Genetic factors in colorectal cancer
- Artificial Intelligence in Healthcare
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Ferroptosis and cancer prognosis
Centro Universitário Una
2025
Vall d'Hebron Institute of Oncology
2024
Vall d'Hebron Hospital Universitari
2022-2024
As doenças cardiovasculares (DCV) continuam a ser principal causa de morte em todo o mundo, representando uma preocupação saúde pública global significativa. A elevada prevalência fatores risco, como hipertensão, diabetes, dislipidemias e estilo vida sedentário, contribui para aumento do número casos alta morbimortalidade associada essas condições. Portanto, necessidade estratégias eficazes detecção precoce, diagnóstico preciso prevenção DCV se torna cada vez mais urgente. Nesse cenário,...
ABSTRACT Introduction: Venous dissection and the vascular ligation technique are of critical importance; therefore, given their relevance effectiveness, knowledge is crucial for training medical students. Experience report: Given above, objective study was to report a practical activity, simulating in non-living biological model, 4th-year students, describing steps procedure. Discussion: Practical surgical skills students paramount importance, highlighting its future clinical practice...
O uso de plantas medicinais é uma prática ancestral que vem ganhando espaço na saúde pública brasileira nos últimos anos, especialmente com a implementação da Política Nacional Práticas Integrativas e Complementares (PNPIC) no Sistema Único Saúde (SUS). Esta revisão narrativa tem como objetivo analisar literatura recente sobre o atenção básica, destacando seus benefícios, desafios perspectivas. Foram consultadas bases SciELO, BVS PubMed, priorizando estudos publicados entre 2015 2024. Os...
HER2DX ERBB2 mRNA score captures the dynamic range of expression in both HER2-negative and HER2+ breast cancer (BC). In a previous study (Prat et al. EBiomedicine 2022), predicted clinical status with high performance validation dataset (n=353; AUC=0.96). Here, we evaluated ability to predict HER2+, HER2-low, HER2-0 status. Standardized was centrally on formalin-fixed paraffin-embedded tumors from 1,149 samples (n=1,029) vs. (n=120). We trained new cutoff (by means decision trees) HER2-low...
The aim of this study is to assess the performance accredited in-house NGS panel VHIO300 in detection gPV tumor sequencing from patients with BC. We selected 90 (pts) BC prior germline genetic diagnosis and available tissue (primary or metastatic samples); 45 had a hereditary breast ovarian cancer (HBOC) gene no detected. Blinded was carried out using panel. Frequency true positives (TP), negatives (TN), false (FP) (FN) calculated, as well sensitivity, specificity, positive negative...
Various predictive biomarkers regarding PI3K inhibitors in patients with estrogen receptor-positive breast cancer (BC) have been identified, including oncogenic alterations PIK3CA, but the main response and resistance pathways are still unknown. Here we explored transcriptomic landscape to PIK3CA inhibitor taselisib endocrine therapy relation mutations treatment LORELEI trial (NCT02273973). enrolled postmenopausal HR-positive/HER2-negative early BC. Neoadjuvant was given for 16 weeks. RNA...
INTRODUÇÃO: O transtorno do déficit de atenção com hiperatividade (TDAH) é classificado como um neurodesenvolvimento que acomete diversas crianças. Trata-se problema saúde pública e se caracteriza pelas alterações comportamentais desatenção, impulsividade. OBJETIVOS: Diante da relevância tema, o presente trabalho tem finalidade abordar os métodos diagnósticos tratamento TDAH em METODOLOGIA: foi desenvolvido a partir uma revisão integrativa literatura, por meio pesquisas nas bases dados...