A5020730844- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Global Cancer Incidence and Screening
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Screening and Detection
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Chemotherapy-induced cardiotoxicity and mitigation
- Breast Lesions and Carcinomas
- Neutropenia and Cancer Infections
- Estrogen and related hormone effects
- Colorectal Cancer Surgical Treatments
- Clinical practice guidelines implementation
- Multiple and Secondary Primary Cancers
- BRCA gene mutations in cancer
- Monoclonal and Polyclonal Antibodies Research
- Patient-Provider Communication in Healthcare
- Primary Care and Health Outcomes
- Cancer survivorship and care
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Risks and Factors
- Cancer therapeutics and mechanisms
- Endometrial and Cervical Cancer Treatments
- Cardiac and Coronary Surgery Techniques
Azienda Ospedaliero-Universitaria Careggi
2018-2024
Azienda Sanitaria di Firenze
2004-2013
Istituto Oncologico Veneto
2013
Istituti di Ricovero e Cura a Carattere Scientifico
2013
National Cancer Institute
2013
Institute for Research on Population and Social Policies
2013
National Research Council
2013
Emory University
2013
Assistance Publique – Hôpitaux de Paris
2013
Ospedale Santa Maria Annunziata
2004
To investigate whether paclitaxel and docetaxel influence the pharmacokinetics metabolism of epirubicin.We studied biotransformation patterns epirubicin in 27 cycles 20 breast cancer patients. Four patients received alone 90 mg/m(2) by intravenous (IV) bolus; eight same dose followed immediately 175 a 3-hour infusion; other 70 1-hour infusion. Epirubicin its metabolites, epirubicinol (EOL) 7-deoxydoxorubicinone (7d-Aone), were identified high-pressure liquid chromatography.No pharmacokinetic...
PURPOSE: Sequence-dependent clinical and pharmacokinetic interactions between paclitaxel doxorubicin have been reported. Some data shown an influence of on epirubicin metabolism, but no are available about the effect diverse sequences these drugs. We investigated whether reversing sequence affects pattern or degree toxicity pharmacokinetics. PATIENTS AND METHODS: Patients receiving 90 mg/m 2 by intravenous bolus followed 175 over 3-hour infusion opposite every 3 weeks for four cycles were...
To evaluate the quality of patients care, a set indicators standards cancer care were defined. We developed to assess implementation in daily practice recommendation produced by regional network (Istituto Toscano Tumori). This was tested retrospective study resident population Tuscany Region; health system is organized on 12 local authorities which refer three macro areas (Area Vasta). The included incident colorectal, lung and breast cases listed 2004 for Tuscan Cancer Registry,...
This monograph highlights the multiple payoffs from comparing patterns of cancer care, costs, and outcomes across health systems, both within a single country or countries, at point in time over time. The focus comparative studies can be on relative performance systems delivering quality controlling cost improving outcomes, such as reducing mortality rates survival. also effectiveness, cost, cost-effectiveness competing prevention control interventions given system while taking into account...
Due to changes in cancer-related risk factors, improvements diagnostic procedures and treatments, the aging of population, most developed countries cancer accounts for an increasing proportion health care expenditures. The analysis costs is a topic several economic epidemiological studies represents research area great interest public planners policy makers. In Italy are limited either some specific types expenditures or groups patients. Aim paper estimate distribution survivors associated...
In Italy, breast cancer is the most frequently diagnosed in women, with 55,900 new cases 2023 (over 90% early stages). Due to screening, diagnosis and adjuvant treatment, these patients have a 5-years survival rate of 87% after diagnosis. There are 834,154 women Italy previous cancer: require follow-up. The AIOM, ESMO ASCO Guidelines recommend for (EBC) clinical follow-up only physical examination (and eliciting symptoms) an annual X-ray mammography, on basis results two randomized trials...
Trastuzumab prolongs survival of human epidermal growth factor receptor 2-positive breast cancer patients in both the adjuvant and metastatic settings. Currently toxicity data are not available on retreatment who relapse after trastuzumab. We report one patient with developed acute thrombocytopenia trastuzumab infusion. This had treatment setting.A 70-year-old Caucasian woman received a diagnosis four years her initial locally advanced, hormone receptors-positive, cancer. was planned. Less...
Cancer is a major component of health-care expenditures in most developed countries. The costs cancer care are expected to increase due rising incidence (as the population ages) and increasing use targeted anticancer therapies. However, epidemiological analysis patterns may be required prior empirically well-grounded cost analyses. Additionally, comparisons between delivery systems countries can identify opportunities improve practice. They also understanding patient outcomes economic...
To evaluate the rate of early breast cancer (EBC) patients treated with neoadjuvant systemic therapy (NAT) in Italy, criteria patient selection and types therapies delivered, an analysis 1276 stage I-II-III was conducted out 1633 enrolled multicenter prospective observational BRIDE study. A total 177 (13.9%) were NAT 1099 (85.9%) surgery; multivariate analysis, menopausal status, cT, cN, grade, HER2-positive Triple negative (TN) subgroups significantly associated decision to administer NAT....
Abstract Background Despite recommendations, mammography screening is often insufficiently integrated into specialist breast centres. A national, cross-sectional, voluntary, online survey on this issue was carried out among the Italian centres associated with Senonetwork, network of cancer services. Methods 73-item questionnaire created, pre-tested and piloted. Centres integrating not a programme were compared using unified theory acceptance use technology (UTAUT) model. Centres’ clustering...
This article aims to present the results of a national, cross-sectional, voluntary, online survey on presence and roles associations breast cancer patients volunteers in Italian specialist centres. The was developed according standard methods. questionnaire pre-tested by random sample three centres, loaded onto SurveyMonkey platform, piloted one volunteer centre. centre clinical leads were invited participate via email. A link instrument provided. No financial incentives offered. reported...