A5008339064- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Epigenetics and DNA Methylation
- Cancer Risks and Factors
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- PARP inhibition in cancer therapy
- Cancer Treatment and Pharmacology
- Hedgehog Signaling Pathway Studies
- Cervical Cancer and HPV Research
- Glioma Diagnosis and Treatment
- Microtubule and mitosis dynamics
- RNA and protein synthesis mechanisms
- Endometrial and Cervical Cancer Treatments
- Cancer-related Molecular Pathways
- Birth, Development, and Health
- Nutrition, Genetics, and Disease
- PI3K/AKT/mTOR signaling in cancer
- Genetics, Bioinformatics, and Biomedical Research
- Mathematical Biology Tumor Growth
- Kruppel-like factors research
Addenbrooke's Hospital
2012-2024
University College Hospital
2023
Cancer Research UK Cambridge Center
2023
University of Cambridge
2014-2023
University College London
2023
Cancer Research UK
2014-2023
Cambridge University Hospitals NHS Foundation Trust
2022-2023
National Institute for Health Research
2022
The Francis Crick Institute
2020
Dana-Farber Cancer Institute
2010-2013
BRCA1-associated breast tumors display loss of BRCA1 and frequent somatic mutations PTEN TP53. Here we describe the analysis BRCA1, PTEN, p53 at single cell level in 55 computational methods to predict relative temporal order events, on basis frequency cells with or combined alterations. Although there is no obligatory found that most common first event associated basal-like subtype, whereas majority luminal tumors, mutation TP53 occurs mutant PIK3CA rarely detected. We also observed...
Abstract Background TP53 and BRCA1/2 mutations are the main drivers in high-grade serous ovarian carcinoma (HGSOC). We hypothesise that combining tissue phenotypes from image analysis of tumour sections with genomic profiles could reveal other significant driver events. Results Automatic estimates stromal content combined TCGA HGSOC tumours show stroma strongly biases PTEN expression. Tumour-specific expression was tested two independent cohorts using microarrays containing 521 cases HGSOC....
PTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade (LGSOC)). We aimed to characterise expression as biomarker epithelial large population-based study.
High-grade serous ovarian carcinoma (HGSOC) is the most genomically complex cancer, characterized by ubiquitous
Chromosomal instability is a major challenge to patient stratification and targeted drug development for high-grade serous ovarian carcinoma (HGSOC). Here we show that somatic copy number alterations (SCNAs) in frequently amplified HGSOC cancer genes significantly correlate with gene expression methylation status. We identify five prevalent clonal driver SCNAs (chromosomal amplifications encompassing MYC, PIK3CA, CCNE1, KRAS TERT) from multi-regional data reason their strong selection should...
High-grade serous ovarian carcinoma (HGSOC) is characterised by poor outcome and extreme chromosome instability (CIN). Therapies targeting centrosome amplification (CA), a key mediator of missegregation, may have significant clinical utility in HGSOC. However, the prevalence CA HGSOC, its relationship to genomic biomarkers CIN potential impact on therapeutic response not been defined. Using high-throughput multi-regional microscopy 287 HGSOC tissues 73 cell lines models, here we show that...
The objectives of the study were to highlight some differences in training systems and opportunities for gynecologic oncology across Europe draw attention steps that can be taken improve prospects experiences European trainees oncology.The Network Young Gynaecological Oncologists national representatives from 34 countries asked review summarize system their origin fulfill a mini-questionnaire evaluating different aspects training. We report analysis outcomes subsequent discussion at Asian...
Goals Expression of GLUT-1 and transglutaminase 2 is increased in aggressive breast cancer, whereas claudin-1, which expressed normal tissues, absent such tumors. This experimental study was undertaken to establish the aggressiveness prognosis DMBA-induced mammary tumors female Wistar rats based on assessment these markers. Materials methods The were divided into two groups, a control group (n = 70) chemoprevention 70). Breast induced both groups by administration...
Objectives: To determine the incidence of cervical cancer in women referred through two-week-wait pathway for postcoital bleeding and abnormal appearance cervix calculate associated costs. Design: A retrospective cohort study. Setting: United Kingdom. Population: 604 with seen colposcopy clinics over five years. Methods: Women were identified from a departmental database. Clinical demographic data was collected. Categorical analysed Chi-squared or Fisher’s exact tests predictive values...
Although intratumoral chemotherapy administration has been evaluated in the past, its results have not frequently comparable to those from systemic administration. We recently described microdialysis as a method for local with increasing effectiveness while reducing toxicity. present mathematical model which supports successful application of this procedure optimizing administered drug different cases, using informatics tools and considering several parameters. also review discuss important...
Abstract Cytotoxic chemotherapies have been a crucial part of cancer treatment for over 40 years. While their primary target is cells, they can also harm normal resulting in dose-limiting toxicity. Most were approved before the advent precision biomarkers, as such, many patients experience severe toxic side effects without any benefit. To address this challenge, we developed three biomarkers to predict response platins, taxanes, and anthracyclines. Based on chromosomal instability (CIN)...
Vulvo-vaginal melanomas are one of the rarest gynecological oncology diseases with a poor survival compared other malignancies. The 5-year varies from 13% to 32.3%. involving upper 2/3rds vagina usually treated total pelvic exenteration (TPE). TPE surgery carries 50% risk major complications and also morbidity associated double stomas. Central compartment resection is novel organ-sparing surgical approach entailing radical laparoscopic hysterectomy, bilateral salpingo-oophrectomy,...
Early full-term pregnancy is the only recognized factor able to prevent breast cancer. There are several hypotheses explain mechanisms of this protection, namely an altered hormonal milieu, a differentiation process or switch in stem cell properties. To explore them, authors have been using animal models, mainly rodents. Hormonal administration with estrogen and progesterone was most widely used mimic mammary changes during pregnancy. We recently proposed that enigmatic protective role birth...
Stem cells may have an important etiological role in cancer. Their classic regulatory pathways are deregulated tumors, strengthening the stem cell theory of In this manuscript, we review Wnt, Notch and Hedhehog pathways, describing which their factors be responsible for neoplastic development. Furthermore, classify these elements as oncogenes or tumor suppressor genes, demonstrating mutation implications The activation is associated with expression certain genes maintain proliferation...
Abstract The genomic complexity and heterogeneity of high-grade serous ovarian cancer (HGSOC) has hampered the realisation successful therapies effective personalised treatment is an unmet clinical need. Here we show that primary HGSOC spheroid models can be used to predict drug response use them demonstrate somatic copy number alterations (SCNAs) in frequently amplified genes significantly correlate with gene expression response. These are often located areas genome frequent clonal SCNAs....