A5062643198- Advanced Fluorescence Microscopy Techniques
- Optical Coherence Tomography Applications
- Advanced Fiber Laser Technologies
- Photoacoustic and Ultrasonic Imaging
- Digital Holography and Microscopy
- Photonic Crystal and Fiber Optics
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cell Image Analysis Techniques
- Laser-Matter Interactions and Applications
- Photoreceptor and optogenetics research
- Advanced Fiber Optic Sensors
- Bee Products Chemical Analysis
- Advanced Sensor and Energy Harvesting Materials
- Neural dynamics and brain function
- Infrastructure Maintenance and Monitoring
- 3D Surveying and Cultural Heritage
- Insect and Pesticide Research
- Neuroscience and Neural Engineering
- Biosensors and Analytical Detection
- Conducting polymers and applications
- AI in cancer detection
- Plant and animal studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Gold and Silver Nanoparticles Synthesis and Applications
- Molecular Sensors and Ion Detection
Wenzhou Medical University
2025
China Construction Eighth Engineering Division (China)
2023-2025
Tsinghua University
2011-2024
Chinese Institute for Brain Research
2019-2024
Eye & ENT Hospital of Fudan University
2023-2024
Institute of Apiculture Research
2018-2023
Chinese Academy of Agricultural Sciences
2018-2023
Ministry of Agriculture and Rural Affairs
2023
McGovern Institute for Brain Research
2023
Beijing Wuzi University
2023
Abstract Stretchable physical sensors that can detect and quantify human physiological signals such as temperature, are essential to the realization of healthcare devices for biomedical monitoring human–machine interfaces. Despite recent achievements in stretchable electronic using various conductive materials structures, design optics remains a considerable challenge. Here, an optical strategy temperature sensors, which maintain stable performance even under strain deformation up 80%, is...
Flexible and stretchable strain sensors are essential to developing smart wearable devices for monitoring human activities. Such have been extensively exploited with various conductive materials structures, which, however, normally in need of complex manufacturing processes confronted the challenge achieve both large stretchability high sensitivity. Here, we report a simple low-cost optical strategy design which capable measuring strains 100% low detection limit (±0.09%), fast responsivity...
Abstract Wearable and skin‐mountable strain sensors are highly demanding for monitoring skin deformations induced by human activities. Realization of such sensor devices based on fiber‐optic approaches offers attractive advantages as electromagnetic immunity inherent electric safety in comparison to their electronic counterparts. However, sensors, conventionally made stiff silica fibers, not mechanically compliant with the soft skins have limited range (<1%) measuring large deformations....
Stimulated Raman scattering (SRS) microscopy allows label-free chemical imaging based on vibrational spectroscopy. Narrowband excitation with picosecond lasers creates the highest signal levels and enables speeds up to video-rate, but it sacrifices specificity in samples overlapping bands compared broadband (multiplex) excitation. We develop a rapidly tunable optical parametric oscillator an electro-optical Lyot filter, demonstrate multicolor SRS synchronized line-by-line wavelength tuning...
We present a fiber-format picosecond light source for coherent anti-Stokes Raman scattering microscopy. Pulses from Yb-doped fiber amplifier are frequency converted by four-wave mixing (FWM) in normal-dispersion photonic crystal to produce synchronized two-color pulse train. show that seeding the FWM process overcomes deleterious effects of group-velocity mismatch and allows efficient conversion into narrow bands. The generates more than 160 mW nearly transform-limited pulses tunable 775 815...
Abstract Benefitting from the advantages of high imaging throughput and low cost, wide-field microscopy has become indispensable in biomedical studies. However, it remains challenging to record biodynamics with a large field view spatiotemporal resolution due limited space–bandwidth product. Here we propose random-access (RA-WiFi) mesoscopy for vivo over 163.84 mm 2 area spatial ~2.18 μm. We extend beyond nominal value objective by enlarging object distance, which leads lower angle, followed...
Traditional manual concrete vibration work faces numerous limitations, necessitating the need for efficient automated methods to support this task. This study proposes a path safety optimization method based on safe flight corridors and Euclidean signed distance fields, which is suitable flexible autonomous movement of vibrating robots between various points. By utilizing vector generate optimizing with proposed reduces runtime by 80% compared original corridor enhances 50%. On embedded...
Systemic lupus erythematosus (SLE) is characterized by aberrant immune activation and disrupted iron metabolism, yet the molecular mediators that govern both processes remain unclear. This study aims to identify pivotal genes modulate responses delineate their contributions SLE pathogenesis. Differentially expressed related metabolism (IM-DEGs) were identified using datasets (GSE72326, GSE110169, GSE126307, GSE50772) from GEO database MSigDB. Functional enrichment analyses performed on...
Insulin resistance has a critical role in type 2 diabetes. The aim of this study was to investigate the effect pinobanksin, galangin, chrysin, and pinocembrin from propolis on insulin resistance. Our shows that galangin can ameliorate resistance; contrary, pinobanksin chrysin are ineffective. Galangin treatments substantially increase glucose consumption glycogen content by enhancing activities hexokinase pyruvate kinase. treatment with 80 μM increased kinase 21.94% 29.12%, respectively....
Advances in fluorescent nanomaterials and photonics have led to a new generation of photonic devices for applications biosensing, diagnostics, therapy. However, clinical utility, biocompatibility limited light guiding tissues pose significant challenges. Here, we report type soft, biocompatible, tapered optical waveguide with capability delivering deep demonstrate it as ratiometric probe rapid point-of-care detection metal ions. The was made from quantum dots (QDs)-incorporated biocompatible...
In vivo detection of neurochemicals, including neurotransmitters and neuromodulators, is critical for both understanding brain mechanisms diagnosing diseases. However, few sensors are competent in monitoring neurochemical dynamics at high specificity. Here, we propose the fiber-optic probes based on engineered cells (FOPECs) plug-and-play, real-time neurochemicals freely moving animals. Taking advantages life-evolved receptors as key components, chemical specificity FOPECs unprecedented. We...
We demonstrate a low-repetition-rate all-fiber all-normal-dispersion Yb-doped mode-locked fiber laser. Stable mode-locking is achieved by nonlinear polarization rotation and its spectral-filtering effect. Nanosecond pulses with steep edges spectrum at repetition rate 217.4 kHz are achieved. Our preliminary experiment shows that it promising seed for amplifier system.
Control of nonlinearity is a challenge in fiber amplifiers designed to generate pulses few picoseconds duration, and as result, picosecond have failed reach peak power 1MW. Divided-pulse amplification, combined with the use circular polarization, allows generation 2.2 ps energy high 2.5 μJ 1 MW.
We demonstrate a novel and compact FBG interrogation system for multiplexed static strain sensing with free running mode-locked fiber laser. Multiplexed array in cascading are interrogated by coherent dual-comb pulses generated from single Dual-comb spectroscopy is achieved the laser to precisely detect strain-induced spectral shifts of sensors. Multi-point measurements performed characterize proposed system, where large dynamic range 520 με 0.5 resolution achieved.
Abstract Glucose monitoring sensors with high softness and flexibility are critical for the developments of wearable implantable healthcare devices that enable diagnosis, prognosis, management diabetes. The design implementation such have been extensively exploited by electrochemical strategies, which, however, suffer from poor reusability complex modification procedures, necessitate frequent calibration or sensor replacement due to enzymatic reaction instability. Here, a soft plasmonic...