A5101931054- Functional Brain Connectivity Studies
- Peptidase Inhibition and Analysis
- Visual perception and processing mechanisms
- Neuropeptides and Animal Physiology
- Ophthalmology and Visual Impairment Studies
- Neural dynamics and brain function
- Optical Imaging and Spectroscopy Techniques
- Obsessive-Compulsive Spectrum Disorders
- Chemical Synthesis and Analysis
- Analytical chemistry methods development
- Antibiotics Pharmacokinetics and Efficacy
- Eating Disorders and Behaviors
- Pesticide Residue Analysis and Safety
- Cardiac Structural Anomalies and Repair
- Advanced Neuroimaging Techniques and Applications
- Diet and metabolism studies
- Renal Diseases and Glomerulopathies
- Breast Lesions and Carcinomas
- Body Image and Dysmorphia Studies
- Mental Health Research Topics
- Bioinformatics and Genomic Networks
- Enzyme function and inhibition
- Hemoglobinopathies and Related Disorders
- Mast cells and histamine
- Attention Deficit Hyperactivity Disorder
First Affiliated Hospital of Zhengzhou University
2020-2025
Huazhong University of Science and Technology
2024
Ministry of Ecology and Environment
2024
Zhengzhou University
2021
Zhengzhou Children's Hospital
2021
Soochow University
2017
First Affiliated Hospital of Soochow University
2017
Weifang University of Science and Technology
2014
Shandong University
2008-2012
Jilin University
2010-2011
To investigate the alterations in spontaneous brain activity and similarities differences between monocular deprivation amblyopia binocular amblyopia. Twenty children with amblyopia, 26 20 healthy controls underwent resting-state functional magnetic resonance imaging. The evaluation of altered was conducted using fractional amplitude low-frequency fluctuations (fALFF). One-way analysis variance employed to analyze fALFF values among three groups. Additionally, relationship best corrected...
Obsessive-compulsive disorder (OCD) is a highly heterogeneous disorder, with notable variations among cases in structural brain abnormalities. To address this heterogeneity, our study aimed to delineate OCD subtypes based on individualized gray matter morphological differences. We recruited 100 untreated, first-episode patients and 106 healthy controls for imaging scans. Utilizing normative models of volume, we identified individual Sensitivity analyses were conducted validate the...
To investigate the alterations in dynamic neural activity visual cortex children with monocular amblyopia and its correlation neurotransmitter profiles. A total of 61 participants (thirty right eye amblyopia, thirty-one left amblyopia) 30 individuals normal vision were recruited. The functional changes brain areas, amplitude low‑frequency fluctuations (dALFF) serves as primary index. Spatial between dALFF imaging was also examined. Abnormal lingual gyrus, middle occipital calcarine fissure...
Abstract Halogenated disinfection byproducts are contaminants in drinking water that pose a significant public health concern. The intestine is particularly susceptible to the effects of through oral ingestion; however, intestinal toxicity these compounds remains largely unexplored. This study aimed assess impact ten haloacetic acids, major class byproducts, on barrier function using Caenorhabditis elegans as model animal. Additionally, changes expression five genes related (mucin-like gene...
IgA nephropathy (IgAN) is the most common primary glomerulonephritis characterized by human mesangial cells (HMC) proliferation and extracellular matrix expansion associated with immune deposits consisting of galactose-deficient IgA1. However, how IgA1 contributes to IgAN has yet be completely elucidated. In this study, expression profile chemokines was more altered in IgA1-treated HMC than control group. CCL20 significantly higher either serum patients or HMC. Further experiments...
The association between visual abnormalities and impairments in cerebral blood flow brain region potentially results neural dysfunction of amblyopia. Nevertheless, the differences complex mechanisms network coupling its relationship with neurotransmitters remain unclear. Here, neurovascular mechanism neurotransmitter activity children anisometropic amblyopia (AA) deprivation (VDA) was explored. 17 regions significantly abnormal than normal controls. classification abilities units differed...
Abstract A new method was developed for the determination of six fluoroquinolone antibiotics including fleroxacin, levofloxacin, ciprofloxacin, lomfloxacin, enrofloxacin, and sparfloxacin in chicken breast muscle, which extraction clean‐up were performed one step by microwave irradiation. The mixture ACN containing 0.3% v/v phosphoric acid/water pH 3 (70:30, v/v) used as solution hexane solution. extract analyzed liquid chromatography–tandem mass spectrometry system. RSDs intra‐ inter‐day...
Abstract Background The present study aims to investigate the role of histogram analysis intravoxel incoherent motion (IVIM) in differential diagnosis benign and malignant breast lesions. Methods magnetic resonance imaging clinical data 55 patients (63 lesions) were retrospectively analyzed. multi-b-valued diffusion-weighted image was processed using MADC software obtain gray-scaled maps apparent diffusion coefficient (ADC)-slow, ADC-fast f. MaZda used extract metrics these maps. Combined...
This study aimed to evaluate the technical success rate and stiffness measurement reliability of two specific hepatic magnetic resonance elastography (MRE) sequences dedicated solving susceptibility artifacts in patients with various degrees iron overload.
Obsessive-compulsive disorder (OCD) may be accompanied by an accelerated structural decline of the brain with age compared to healthy controls (HCs); however, this has yet proven. To answer question, we built a prediction model using mean gray matter volumes each region as features, which were obtained voxel-based morphometry derived from T1-weighted MRI scans. The was two Chinese Han datasets (dataset 1, N = 106 for HCs and 90 patients OCD; dataset 2, 270 HCs) evaluate its performance....
Abstract Introduction Using brain network and graph theory methods to analyze the Alzheimer's disease (AD) mild cognitive impairment (MCI) abnormal function is more popular. Plenty of potential have been proposed, but representative signal each region in these remains poor performance. Methods We propose a highly‐available nodes approach for constructing patients with MCI AD. With resting‐state functional magnetic resonance imaging (rs‐fMRI) data 84 AD subjects, 81 82 normal control (NC)...
Aminopeptidase N (APN/CD13) is one of the essential proteins for tumour invasion, angiogenesis and metastasis as it over-expressed on surface different cells. Based our previous work that L-isoserine dipeptide derivatives were potent APN inhibitors, we designed synthesized tripeptide inhibitors. Among these compounds, compound 16l (IC50 = 2.51 ± 0.2 µM) showed similar inhibitory effect compared with control Bestatin 6.25 0.4 could be used novel lead inhibitors development anticancer agents in future.
Acid-related diseases of the upper gastrointestinal tract, especially gastroesophageal reflux disease (GERD), remain a widespread problem worldwide. In this paper, we reported design, synthesis, and preliminary gastric antisecretory activity evaluation novel pyrimidine derivatives as acid pump antagonists. The assay results showed that all compounds displayed potent when secretion was stimulated by histamine. most compound 5g exhibited even similar compared with control revaprazan, relative...