A5101993290- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Head and Neck Cancer Studies
- Insect symbiosis and bacterial influences
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Hepatitis C virus research
- Cancer-related molecular mechanisms research
- Helicobacter pylori-related gastroenterology studies
- Neuroblastoma Research and Treatments
- Immunotherapy and Immune Responses
- Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Hepatitis B Virus Studies
- Lung Cancer Research Studies
- PARP inhibition in cancer therapy
- Tryptophan and brain disorders
- Lipid metabolism and disorders
- Genetic Syndromes and Imprinting
Simcere Pharmaceutical (China)
2022-2025
Nanjing Medical University
2000-2024
First Affiliated Hospital of Anhui Medical University
2024
Jiangsu Province Hospital
2015-2024
Anhui Medical University
2024
Shanghai Ocean University
2020-2023
Shanghai University of Medicine and Health Sciences
2022
University Medical Center Groningen
2021
Shanghai Traditional Chinese Medicine Hospital
2019
Nanjing Normal University
2010
Abstract Metastatic pancreatic cancer (mPC) has a dismal prognosis. Herein, we conducted prospective, multicentre, single-arm, phase II trial evaluating the efficacy and safety of penpulimab anlotinib in combination with nab-paclitaxel/gemcitabine (PAAG) patients first-line mPC (NCT05493995). The primary endpoints included objective response rate (ORR) disease control (DCR), while secondary encompassed progression-free survival (PFS), overall (OS), safety. In 66 analysed for efficacy, best...
Background To compare intravoxel incoherent motion (IVIM) and pharmacokinetic analysis dynamic contrast‐enhanced MR imaging (DCE‐MRI) in distinguishing lung cancer (LC) from benign solitary pulmonary lesions (SPL). Methods This prospective study was approved by the institutional review board, written informed consent obtained. Eighty‐one consecutive patients considered for SPL underwent DW‐IVIM DCE‐3T MRI. ADC, D, D*, f were calculated with mono‐ bi‐exponential models. K trans , k ep v e p...
ABSTRACT The global incidence of biliary tract cancer (BTC) is on the rise, presenting a substantial healthcare challenge. integration immune checkpoint inhibitors (ICIs) with molecularly targeted therapies emerging as strategy to enhance responses. However, efficacy and underlying mechanisms these treatments in BTC are still largely unexplored. In this study, tissue samples from 19 patients treated camrelizumab apatinib were analysed using NanoString 289‐panel identify key molecular...
Abstract The effectiveness of Antibody-Drug Conjugates (ADCs) is closely associated with the level tumor antigen expression and administered drug dose, as observed in both preclinical clinical settings. Trop2-targeted ADCs represent a promising therapeutic approach for various solid tumors; however, their efficacy constrained by levels Trop2 off-tumor, on-target toxicity. To address these limitations, we have developed bi-specific ADC that targets B7H4, aiming to increase overall level,...
CD147 is a widely distributed cell surface glycoprotein that belongs to the Ig superfamily. has been implicated in numerous physiological and pathological activities. Enriched on of many tumor cells, promotes growth, invasion, metastasis angiogenesis confers resistance some chemotherapeutic drugs. In this study, we investigated possible role progression gastric cancer. Short hairpin RNA (shRNA) expressing vectors targeting were constructed transfected into human cancer cells SGC7901...
Abstract Extensive insecticide use has led to the resistance of mosquitoes these insecticides, posing a major barrier mosquito control. Previous Solexa high-throughput sequencing Culex pipiens pallens in laboratory revealed that abundance novel microRNA (miRNA), miR-13664, was higher deltamethrin-sensitive (DS) strain than deltamethrin-resistant (DR) strain. Real-time quantitative PCR miR-13664 transcript level lower DR DS MiR-13664 oversupply increased susceptibility deltamethrin, whereas...
Abstract Background The molecular and immunological characteristics of primary tumors positive lymph nodes in esophageal squamous cell carcinoma (ESCC) are unknown the relationship with recurrence is unclear, which this study attempted to explore. Methods A total 30 ESCC patients node (IIB‐IVA) were enrolled. Among them, tumor specimens collected from each patient, subjected 551‐tumor‐targeted DNA sequencing 289‐immuno‐oncology RNA panel identify different basis features, respectively....
Background β-glucan has been reported to be a potential natural immune modulator for tumor growth inhibition. We aimed evaluate the efficacy and safety of plus immunotherapy chemotherapy in first-line treatment advanced gastric adenocarcinoma. Methods This is phase IB, prospective, single-arm, investigator-initiated trail. Advanced adenocarcinoma patients received β-glucan, camrelizumab, oxaliplatin, oral S-1 every 3 weeks. The curative effect was evaluated 2 cycles. primary endpoints were...
White spot syndrome virus (WSSV) has become one of the most widespread causes mortality in commercial shrimp farming due to its broad host range, rapid spread and high lethality. The tegument protein VP26, which is loosely connected nucleocapsid envelope, major proteins WSSV an important role initial stages viral infection. Recent research emphasized vp26 gene, structure VP26 protein, binding proteins. Such knowledge required develop immune adjuvant control WSSV. This paper reviews related...
Loss of genomic imprinting the insulin-like growth factor 2 gene (IGF2) maybe associated with loss activity CTCF, an insulator transcription, in many human neoplasms. This is because inactive CTCF cannot bind to differentially methylated domains (DMD). results interaction between IGF2 promoters and enhancers produced. In this study we investigated feasibility using a combination expression vectors AdDC3312-EGFP AdDC312-DT-A driven by H19 enhancer DMD-H19 promoter complex. HCT-8, HT-29 H-522...
Objective The purpose of this study was to observe the relationship between physical performance and mild cognitive impairment (MCI) in presence or absence type 2 diabetes elderly hemodialysis patients. Methods In multicenter cross-sectional study, 396 clinically stable aged ≥60 years patients (255 men; mean age: 68.3 ± 5.9 years) were included from seven dialysis units Shanghai, China. Chinese version Modified Mini-Mental State Examination (MMSE) Instrumental Activities Daily Living (IADL)...
X-linked adrenoleukodystrophy (X-ALD) is the most frequent type of inherited demyelinating peroxisomal disease caused by mutations in ATP binding cassette subfamily D member 1 (ABCD1) gene. The rate early recognition and genetic diagnosis X-ALD remains low due to its variable clinical manifestations. present study summarized features Chinese patients performed a follow-up further precisely characterize this disease. A total 10 diagnosed with between 1994 2016 at Shandong Provincial Hospital...
Immune checkpoint inhibitors have limited efficacy in metastatic pancreatic cancer due to the complex tumor immune microenvironment (TIME). Studies shown that radiotherapy can cause cell lesions release antigens and then take part remodeling of environment induction ectopic effects via regional systemic immunoregulation. Here, we reported a case advanced treated with immunotherapy combined chemotherapy sharp shift TIME from T3 T2 was also observed. One hepatic metastasis within planning...
Objective To investigate the correlation between three gene locus polymorphisms of X-ray repair cross-complementary protein 1 (XRCC1) exon (Arg194Trp, Arg280His and Arg399Gln) risk colorectal cancer (CRC). Methods A case-control study was performed in 250 CRC patients (case group, 128 colon 122 rectal patients) 213 healthy individuals (control group). The polymorphism XRCC1 tested by polymerase chain reaction restriction fragment length (PCR-RFLP) method. genotype distribution allele...
Hepatitis C is distributed worldwide and possesses a hidden characteristic. The traditional methods of screening diagnosis hepatitis infection commonly used in clinics are based on anti-HCV antibody HCV RNA detection. Advances antigen detection technologies can apparently reduce the window period for antibodies, providing new clinical evidence early detection, diagnosis, treatment infection. This article current review methodologies, applications, strategies.
To explore the antiviral activity of small-molecule compound AM679 in hepatitis B virus (HBV) replication and infection cell models.
e14540 Background: The use of immunochemotherapy has brought about a change in the treatment advanced or metastatic GC/GEJC, but only subset patients could benefit substantially. Therefore, seeking efficacious biomarkers to identify favorable populations for regimen is imperative. This study aims explore predictive markers and potential mechanism combination therapy GC/GEJC real-world settings based on blood proteomic biopsy. Methods: prospective, single-center trial which all are adults...
4135 Background: Chemotherapy currently serves as the cornerstone for treating metastatic pancreatic cancer (mPC). Nevertheless, survival of patients with mPC remains poor. Besides, efficacy single-agent immune checkpoint inhibitors or antiangiogenesis in treatment is not satisfying. Therefore, it important to explore combination therapy options mPC. This trial was conducted evaluate effectiveness and safety penpulimab combined anlotinib nab-paclitaxel plus gemcitabine (PAAG) Methods: a...
Persistent infection with high-risk HPV is a known cause of cervical cancer. Minimal residual disease (MRD) increasingly well recognized in guiding adjuvant therapy for colorectal and lung cancer, exploring its role cancer essential improving patient outcomes. This study investigates the prognostic potential circulating tumor DNA (ctHPV-DNA) monitoring treatment response predicting recurrence The prospective, observational clinical (NCT05602831) enrolled patients undergoing radical...