A5064729562- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Ovarian cancer diagnosis and treatment
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Testicular diseases and treatments
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Pancreatic and Hepatic Oncology Research
- Gestational Trophoblastic Disease Studies
- Cytokine Signaling Pathways and Interactions
- RNA Research and Splicing
- PARP inhibition in cancer therapy
- Gastrointestinal Tumor Research and Treatment
- BRCA gene mutations in cancer
- Helicobacter pylori-related gastroenterology studies
Nanjing Medical University
2022-2024
Jiangsu Province Hospital
2022-2024
China Three Gorges University
2021
This study mainly focuses on revealing the role of circRPPH1 in gastric cancer cell stemness. In vitro and vivo experiments were performed to evaluate effects Luciferase reporter RIP assays implemented reveal underlying mechanisms. MiR-375 directly bound cells. And acted as an miR-375 sponge positively regulate SLC7A11 expression, which has been confirmed be direct target cancer, thus regulated ferroptosis. Moreover, promoted stemness cells dependent miR-375/SLC7A11. provides a potential for...
Programmed Death Receptor 1 (PD-1) inhibitors, when combined with chemotherapy, have exhibited notable effectiveness in enhancing the survival outcomes of patients afflicted advanced gastric cancer. However, it is important to acknowledge that not all derive substantial benefits from this therapeutic approach, highlighting crucial necessity identifying efficacious biomarkers inform immunotherapy interventions. In study, we sought investigate predictive utility circulating tumor DNA (ctDNA)...
e14540 Background: The use of immunochemotherapy has brought about a change in the treatment advanced or metastatic GC/GEJC, but only subset patients could benefit substantially. Therefore, seeking efficacious biomarkers to identify favorable populations for regimen is imperative. This study aims explore predictive markers and potential mechanism combination therapy GC/GEJC real-world settings based on blood proteomic biopsy. Methods: prospective, single-center trial which all are adults...
Circular RNAs (circRNAs) have been reported to be associated with the malignant phenotypes of cancer. However, role and underlying mechanism hsa_Circ_0008035 in colorectal cancer (CRC) remains unclear. In this study, we elucidated pivotal hsa_circ_0008035 gastric progression immune evasion. Elevated levels patient serum correlated positively disease advancement, including tumor stages lymph node metastasis. Functional analyses revealed a negative association between CD8+ T cell number...
3042 Background: Combination therapy with Programmed Death 1 (PD-1) inhibitors and chemotherapy has shown efficacy in improving survival advanced gastric cancer, but not all patients derive benefit. We aimed to explore whether early dynamic changes circulating tumor DNA (ctDNA) can serve as predictors of treatment response long-term receiving first-line PD-1 combined chemotherapy. Methods: This is a prospective, single-center trial which are adults or metastatic GC/GEJC confirmed by...
As it is known, long non-coding RNA (lncRNA) affects tumor progression, which has caused a great upsurge in recent years. It can also affect the growth, migration, and invasion of tumors. The abnormal expression lncRNA associated with malignant In addition, been proved that key targeted gene for treatment some diseases. PART1, member lncRNA, reported as regulator process occurrence development. This study aims to reveal biological functions, specific mechanisms, clinical significance PART1...