A5075798381- Bone fractures and treatments
- Reconstructive Surgery and Microvascular Techniques
- Epigenetics and DNA Methylation
- Neuroendocrine regulation and behavior
- Orthopedic Surgery and Rehabilitation
- Orthopedic Infections and Treatments
- RNA modifications and cancer
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal motility and disorders
- Systemic Lupus Erythematosus Research
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Peroxisome Proliferator-Activated Receptors
- Musculoskeletal synovial abnormalities and treatments
- Hip and Femur Fractures
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Surgical site infection prevention
- Reconstructive Facial Surgery Techniques
- Peptidase Inhibition and Analysis
- Gut microbiota and health
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Bone and Joint Diseases
China Medical University
2019-2025
Kunming Medical University
2020-2025
Chinese Academy of Medical Sciences Dermatology Hospital
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2025
Shanxi Agricultural University
2023-2025
Huazhong University of Science and Technology
2025
Jiangsu Province Hospital
2024
Shanghai University of Engineering Science
2024
Nanjing University of Chinese Medicine
2023-2024
Jiangsu Vocational College of Medicine
2020-2024
Methyltransferase-like protein 3 (METTL3) regulates multiple cell functions and diseases by modulatingN 6methyladenosine (m 6 A) modifications.However, it is still unclear whether METTL3 involves in the pathogenesis of diabetic retinopathy (DR).In present study, we found that high-glucose inhibited RPE proliferation, promoted apoptosis pyroptosis a time-dependent manner.In addition, both mRNA miR-25-3p were low-expressed peripheral venous blood samples diabetes mellitus (DM) patients...
Rationale:Necroptosis is a programmed form of non-apoptotic cell death that requires receptor-interacting protein 3 (RIP3).RIP3 has been shown to be relevant in multiple tumor types and differential impact on progression.We investigated whether RIP3 involved the progression colitis-associated cancer (CAC) mice.Methods: Tissues from colorectal patients were examined for expression.CAC was induced using azoxymethane (AOM) injection followed by dextran sodium sulfate (DSS) treatment...
Animals have evolved distinct small RNA pathways, including piRNA and siRNA, to silence invasive selfish nucleic acids. pathway factors are concentrated in perinuclear germ granules that frequently associate with nuclear pore complexes (NPCs). However, the mediating granule-NPC association functional relevance of such remain unknown. Here we show conserved nucleoporins NPP-14 (NUP-214) NPP-24 (NUP-88), components cytoplasmic filaments NPC, play critical roles anchoring granule NPC...
In this study, Acidthiobacillus ferrooxidans LX5 was used as an experimental microbial strain, and differences in biological oxidation between high-sulfur coal pure pyrite were thoroughly investigated over 18 days acidic environments with initial pH values of 1.70, 2.00, 2.30, 2.60. The results showed that the bio-oxidation efficiency desulfurization system exceeded at same pH. net increase SO42− concentration increased increasing values, consistent trend system. 2.60 reached 4589.06 mg/L...
The influenza viral hemagglutinin (HA) is comprised of two subunits. Current vaccine predominantly induces neutralizing antibodies (Abs) against the HA1 subunit, which constantly evolving in unpredictable fashion. other HA2, however, highly conserved but largely shielded by HA head domain. Thus, enhancing immune response HA2 could potentially elicit broadly inhibitory Abs. We generated a recombinant adenovirus (rAd) encoding secreted fusion protein, consisting codon-optimized subunit...
The presence of liver cancer stem cells (LCSCs) is one the reasons for treatment failure hepatocellular carcinoma (HCC). For LCSCs, their prominent features metabolism plasticity, which depends on transporters and ion channels to exchange metabolites ions. K+ channel protein KCNN4 (Potassium Calcium-Activated Channel Subfamily N Member 4) has been reported promote cell malignant progression HCCs, but its influence LCSC stemness remained unclear. Here, we demonstrated that was highly...
Abstract Background Large post-traumatic tibial bone defects combined with soft tissue are a common orthopedic clinical problem associated poor outcomes when treated using traditional surgical methods. The study was designed to investigate the safety and efficacy of trifocal transport (TFT) soft-tissue Ilizarov technique for large posttraumatic defects. Methods We retrospectively reviewed 31 patients massive from May 2009 2016. All eligible were managed by TFT transport. median age 33.4...
Metastasis is the main cause of cancer patients' death despite tremendous efforts invested in developing related molecular mechanisms. During cell migration, cells undergo dynamic regulation filopodia, focal adhesion, and endosome trafficking. Cdc42 imperative for maintaining morphology regulating movement. Integrin beta1 activates on endosome, majority which distributes itself plasma membrane, indicating that endocytic trafficking essential this activity. In cancers, high expression...
Cerebral ischemia/reperfusion injury impairs learning and memory in patients. Studies have shown that synaptic function is involved the formation development of memory, DNA methylation plays a key role regulation memory. To investigate hypomethylation cerebral injury, this study, we established rat model by occlusion middle artery then treated rats with intraperitoneal 5-aza-2′-deoxycytidine, an inhibitor methylation. Our results showed 5-aza-2′-deoxycytidine markedly improved neurological...
Cysteinyl leukotriene receptor 1 (CYSLTR1) is observed to increase in psoriatic skin lesions.Montelukast, a CYSLTR1 antagonist, effectively treats inflammatory disorders, such as rheumatoid arthritis, multiple sclerosis, and atopic dermatitis.Thus, blocking may be promising strategy for psoriasis immunotherapy.We prepared montelukast sodium cream solution investigated their effects on psoriasis-like lesions induced by imiquimod (IMQ).After the treatment, serum, skin, spleen samples were...
Intestinal metaplasia (IM) is a premalignant condition that increases the risk for subsequent gastric cancer (GC). Traditional Chinese medicine generally plays role in treatment of IM, and phytochemical naringenin used herbal has shown therapeutic potential diseases. However, naringenin's specific effect on IM not yet clearly understood. Therefore, this study identified gene targets through bioinformatics analysis experiment validation. Two genes (MTTP APOB) were selected as after comparison...
Hepatocellular carcinoma (HCC) is an aggressive cancer that has effect on human health. As a first-line drug for HCC, despite its excellent efficacy, lenvatinib (Len) prone to developing resistance in HCC patients. The N6-methyladenosine (m6A) modification not only related the development of but also shows great potential overcoming resistance. Using Dot Blot, our group first screened small molecule m6A regulator, lobeline (Lob), from library 390 compounds (mostly natural products). In vitro...
Abstract Methamphetamine (METH) causes memory changes, but the underlying mechanisms are poorly understood. Epigenetic mechanisms, including DNA methylation, can potentially cause synaptic changes in brain. Oxytocin (OT) plays a central role learning and memory, little is known of impact OT on METH‐associated changes. Here, we explored METH‐induced epigenetic alterations that underlie spatial cognitive METH (2.0 mg/kg, i.p.) was administered to male C57BL/6 mice once every other day for 8...
Abstract Background Infected bone defect poses a great challenge for orthopedists because it is difficult to cure. Tissue-engineered based on the human mesenchymal stem cells (hMSCs), has currently taken promising treatment protocol in clinical practice. In previous study, porous hydroxyapatite/fibronectin/alginate (PHA/FN/ALG) composite scaffold displayed favorable biological properties as novel scaffold, which was considered better than single-material scaffolds. addition, Wnt11 been...
Introduction Oral absorption of BCS IV drug benefits little from improved dissolution. Therefore, the nanocrystals ‘as a whole’ strategy is preferred, and structural modification required. Surface helps maintain particle structure before dissolution needed, thus enhancing oral drugs promoting therapeutic effect. Here, main challenges solutions delivery are discussed. Moreover, strategies for nanocrystal surface that facilitates bioavailability highlighted, provide insights innovation in...