A5100429618- Animal Disease Management and Epidemiology
- Corrosion Behavior and Inhibition
- Hydrogen embrittlement and corrosion behaviors in metals
- Vector-Borne Animal Diseases
- Consumer Attitudes and Food Labeling
- Hypothalamic control of reproductive hormones
- Neurosurgical Procedures and Complications
- Dermatology and Skin Diseases
- Coronary Interventions and Diagnostics
- Nutritional Studies and Diet
- Retinoids in leukemia and cellular processes
- Cancer Cells and Metastasis
- Food Quality and Safety Studies
- Sexual function and dysfunction studies
- Obesity, Physical Activity, Diet
- Microbial Metabolic Engineering and Bioproduction
- Neuroinflammation and Neurodegeneration Mechanisms
- T-cell and Retrovirus Studies
- Bone Metabolism and Diseases
- Viral Infections and Immunology Research
- Psoriasis: Treatment and Pathogenesis
- Dendrimers and Hyperbranched Polymers
- Biomarkers in Disease Mechanisms
- Electron and X-Ray Spectroscopy Techniques
- Moyamoya disease diagnosis and treatment
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Chinese Academy of Medical Sciences Dermatology Hospital
2024
Peking Union Medical College Hospital
2024
Northeastern University
2008-2023
Universidad del Noreste
2023
Fudan University
2014
State Key Laboratory of Genetic Engineering
2014
China Medical University
2013
Tianjin Medical University General Hospital
2013
Glioma is the most common primary brain tumor among adults. Temozolomide (TMZ) widely used as first‑line postsurgical drug for malignant glioma. However, therapeutic efficacy of TMZ remains ineffective inherited or acquired resistance frequently observed. Estrogen receptor β (ERβ) has emerged a suppressor and key regulator signal transduction in glioma cells. little known about role ERβ regulating chemotherapeutic response to TMZ. In current study, TMZ‑resistant U138 cells were treated with...
Cysteinyl leukotriene receptor 1 (CYSLTR1) is observed to increase in psoriatic skin lesions.Montelukast, a CYSLTR1 antagonist, effectively treats inflammatory disorders, such as rheumatoid arthritis, multiple sclerosis, and atopic dermatitis.Thus, blocking may be promising strategy for psoriasis immunotherapy.We prepared montelukast sodium cream solution investigated their effects on psoriasis-like lesions induced by imiquimod (IMQ).After the treatment, serum, skin, spleen samples were...
High nitrogen nickel-free austenitic stainless steel (HNNF SS) is one of the biomaterials developed recently for circumventing in-stent restenosis (ISR) in coronary stent applications. To understand ISR-resistance mechanism, we have conducted a comparative study cellular and molecular responses human umbilical vein endothelial cells (HUVECs) to HNNF SS 316L (nickel-containing steel) which material used currently. CCK-8 analysis flow cytometric were assess (proliferation, apoptosis, cell...
Previous studies have demonstrated that magnesium and zinc ions promote the migration epithelial‑mesenchymal transition (EMT) of cancer/endothelial cells. However, impact MgCl2 ZnCl2 on migration, invasion EMT human umbilical vein endothelial cells (HUVECs) involved mechanisms remain unclear. In present study, HUVECs were incubated with various doses ZnCl2. The optimum concentrations selected by MTT assay. capabilities analyzed Transwell assays. Subsequently, expression matrix...
Abstract To evaluate the clinical potential of high nitrogen nickel-free austenitic stainless steel (HNNF SS), we have compared cellular and molecular responses human umbilical artery smooth muscle cells (HUASMCs) to HNNF SS 316L (nickel-containing steel). CCK-8 analysis flow cytometric were used assess (proliferation, apoptosis cell cycle) quantitative real-time PCR (qRT-PCR) was analyze gene expression profiles HUASMCs exposed SS, respectively. demonstrated that cultured on proliferated...
Purpose: A food frequency questionnaire (FFQ) and an attitude/behaviour (ABQ) were developed, their validity reliability tested to determine adolescents’ vegetable fruit (VF) intakes factors influencing choices. Methods: High school students living in the lower mainland of British Columbia participated. The FFQ was adapted from National Cancer Institute VF By-Meal screener, which designed be used with adults. After several focus groups adolescents, revised make it more user-friendly. ABQ...
Inducible costimulator (ICOS) is a member of the CD28 family. When activated, ICOS signalling promotes FOXP3 CNS2 gene demethylation and stabilizes Treg differentiation. Cerebral aneurysm (CA) local ballooning cerebral vasculature, characterized by higher levels inflammation mediators tissue remodelling.
The NS5A non-structural protein of classical swine fever virus (CSFV) is a multifunctional involved in viral genomic replication, translation, assembly infectious particles, and regulation cellular signaling pathways. Previous report showed that inhibited nuclear factor kappa B (NF-κB) induced by poly(I:C); however, the mechanism has not been elucidated. Here, we reported directly interacted with NF-κB essential modulator (NEMO), regulatory subunit IκB kinase (IKK) complex, to inhibit...
ABSTRACT Classical swine fever virus nonstructural protein NS5A is essential for viral genome replication, translation, assembly, and autophagy. In the present paper, interaction of cellular PPP2R1A, PP2Ac, DAPK3 with has been confirmed. These interactions mediate dissociation PP2A from Beclin 1 its association DAPK3. Downregulation or PPP2R1A inhibits CSFV replication. induced phosphorylation Ser88 (PK-15 cells) Ser90 (HEK293T on 1. Knockdown inhibited NS5A-induced autophagy, indicating...
Brain arteriovenous malformation (BAVM) is an abnormality in the cerebral vascular system. Although upregulation of Notch signalling pathway a deterministic factor BAVM, mechanism by which this upregulated patients with BAVM uncertain. The effects serum starvation and endothelial growth (VEGF) stimulation on brain microvascular cells (MECs) mouse embryonic stem (mES)/embryoid body (EB)-derived were investigated study. duration VEGF concentration changed, cell viability was measured,...
Objective To investigate the interrelationship between leptin and 5-hydroxy tryptamine (5-HT)and their significance in diagnosis of premature ejaculation(PE).Methods 71 cases with lifelong PE(the trial group)and 64 healthy males(the control group)were enrolled this case-control study.Baseline recording intravaginal ejaculation latency time(IELT) using a stop watch Chinese Index Premature Ejaculation-5 (CIPE-5) were done.The serum 5-HT levels determined.Then group given sertraline...
Janus kinase (JAK)-STAT plays a critical role in anti-viral immune response. Viruses have evolved various strategies to regulate JAK-STAT signaling for their benefits. This paper shows that CSFV NS5A protein interacts with STAT3 and activates signaling. The overexpression of facilitates replication inhibits IFNα/β IFN-stimulated genes (ISGs) expression. inhibition using inhibitor S3I-201 or the knockdown by siRNA suppresses proliferation enhances ISGs Mechanism analysis blocks nuclear...