A5006922499- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Click Chemistry and Applications
- Crystallization and Solubility Studies
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Protein Degradation and Inhibitors
- X-ray Diffraction in Crystallography
- MicroRNA in disease regulation
- Advanced Breast Cancer Therapies
- RNA modifications and cancer
- Nanoparticle-Based Drug Delivery
- Endoplasmic Reticulum Stress and Disease
- Microbial Natural Products and Biosynthesis
- Aquaculture disease management and microbiota
- Phytochemistry and Biological Activities
- Extracellular vesicles in disease
- Biological Research and Disease Studies
- RNA and protein synthesis mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Circular RNAs in diseases
- Bioactive Natural Diterpenoids Research
- Ubiquitin and proteasome pathways
- Sirtuins and Resveratrol in Medicine
- Advancements in Transdermal Drug Delivery
Qingdao University
2018-2024
Affiliated Hospital of Qingdao University
2020-2024
Xinyang Normal University
2024
Shanghai East Hospital
2024
National Health and Family Planning Commission
2024
China University of Petroleum, East China
2023
Central China Normal University
2021
Yunnan Normal University
2021
Tianjin University
2020
Shanghai Jiao Tong University
2016-2017
Centrosome amplification is frequent in cancer, but the underlying mechanisms remain unclear. Here we report that disruption of Kruppel-like factor 14 (KLF14) gene mice causes centrosome amplification, aneuploidy and spontaneous tumorigenesis. Molecularly, KLF14 functions as a transcriptional repressor Plk4, polo-like kinase whose overexpression induces overduplication. Transient knockdown sufficient to induce Plk4-directed amplification. Clinically, transcription significantly...
Blood transferrin receptor-positive (TfR+) exosomes are a kind of optimized drug delivery vector compared with other kinds due to their easy access and high bio-safety. Their application facilitates the translation from bench bedside exosome-based vehicles. Methods: In this study, pH-responsive superparamagnetic nanoparticles cluster (denoted as SMNC)-based method was developed for precise mild separation blood TfR+ exosomes. Briefly, multiple (SPMNs) labeled transferrins (Tfs) could...
With the increasing public attention being paid to corporate social responsibility and global advocacy of sustainable development, governance issues centered on responsibility, especially relationship between financial sustainability, are important topics concern for managers. By taking companies listed in Shanghai Shenzhen A-share indices 2010 2020 China as samples, this study investigated effect mechanism implementation examined intermediate roles agency cost green innovation effect,...
Mornaphthoate E (MPE) is a prenylated naphthoic acid methyl ester isolated from the roots of famous Chinese medicinal plant
Gastric cancer is one of the most prevalent tumor types in world. Chemotherapy common choice for treatment. However, chemotherapy resistance and adverse side effects limit its clinical applications. Aberrant expression long noncoding RNAs (lncRNAs) has been found various stages gastric development progression. In this study, we identified that an oncogenic lncRNA, intergenic non-protein-coding RNA D63785 (lncR-D63785), highly expressed tissues cells. Silencing lncR-D63785 inhibited cell...
Maintenance of energy homeostasis is essential for cell survival. Here, we report that the ATP- and ubiquitin-independent REGγ-proteasome system plays a role in maintaining survival during starvation via repressing rDNA transcription, major intracellular energy-consuming process. Mechanistically, limits cellular transcription consumption by targeting activator SirT7 degradation under normal conditions. Moreover, induces an AMPK-directed phosphorylation subsequent REGγ-dependent subcellular...
Abstract Triple-negative breast cancer (TNBC) exhibits a high mortality rate and is the most aggressive subtype of cancer. As previous studies have shown that histone deacetylases (HDAC) may represent molecular targets for TNBC treatment, we screened small library synthetic molecules identified potent HDAC inhibitor (HDACi), YF438, which exerts effective anti-TNBC activity both in vitro vivo. Proteomic biochemical revealed YF438 significantly downregulated mouse double minute 2 homolog...
Mitochondrial dysfunction is involved in the pathogenesis of various cardiovascular disorders. Although mitochondrial dynamics, including changes fission and fusion, have been implicated development cardiac hypertrophy, underlying molecular mechanisms remain mostly unknown. Here, we show that NFATc3, miR-153-3p, mitofusion-1 (Mfn1) constitute a signaling axis mediates fragmentation cardiomyocyte hypertrophy. Methods: Isoprenaline (ISO) was used to stimulate hypertrophic response cultured...
Introduction Elderly patients with impaired intrinsic capacity are at increased risk for delayed or suboptimal recovery from surgery. S-ketamine has been proven to improve postoperative quality. However, limited trials studying the quality in elderly capacity. Therefore, objective of this study was evaluate impact on following total knee arthroplasty. Methods and analysis This is a single-centre, randomised, double-blind, placebo-controlled trial. Participants undergoing arthroplasty will be...
Abstract To date, the encapsulation of therapeutic enzymes in a protective matrix is an optimized strategy for maintenance their stability, facilitating clinical application. However, stability and activity are often tension with each other. A rigid may effectively maintain enzymes, but it can reduce diffusion substrates toward enzyme active site, dramatically affecting catalytic efficiency. Here, we exploited kind nanogels by situ polymerization on arginine deiminase (ADI) surface...
Abstract Animal experiments traditionally identify sensitizers in cosmetic materials. However, with growing concerns over animal ethics and bans on such globally, alternative methods like machine learning are gaining prominence for their efficiency cost‐effectiveness. In this study, to develop a robust sensitizer detector model, we first constructed benchmark data sets using from previous studies public database, then 589 831 nonsensitizers were collected. addition, graph‐based autoencoder...
A series of novel coumarin-based hydroxamate derivatives were designed and synthesized as histone deacetylase inhibitors (HDACis). Selective compounds showed a potent HDAC inhibition with nM IC50 values, the best compound (10e) being nearly 90 times more active than vorinostat (SAHA) against HDAC1. Compounds 10e 11d also increased levels acetylated H3 H4, which is consistent their strong inhibition. In addition, displayed higher potency toward human A549 Hela cancer cell lines compared SAHA....
Breast cancer is one of the most lethal cancers in women. Despite significant advances diagnosis and treatment breast cancer, many patients still succumb to this disease, thus, novel effective treatments are urgently needed. Natural product coumarin has been broadly investigated since it reveals various biological properties medicinal field. Accumulating evidence indicates that histone deacetylase inhibitors (HDACIs) promising anti-breast agents. However, current HDACIs exhibit only moderate...
Protein drugs are often loaded on scaffolds with organic coatings to realize a spatiotemporal controlled release. The stability or activity of protein drugs, however, is largely affected by the coating, particularly solvents, which can dramatically reduce their delivery efficiency and limit application scope. In spite this, little attention has been paid maintaining in coatings, date. Here, we used catalase as model drug exploit kind chemically cross-linked nanogel that efficiently...