A5100328410- Glycosylation and Glycoproteins Research
- Catalytic C–H Functionalization Methods
- Carbohydrate Chemistry and Synthesis
- Synthesis and Catalytic Reactions
- Supramolecular Self-Assembly in Materials
- Psoriasis: Treatment and Pathogenesis
- NF-κB Signaling Pathways
- Dermatology and Skin Diseases
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Immune Response and Inflammation
- Alzheimer's disease research and treatments
- Carbon and Quantum Dots Applications
- Quantum Dots Synthesis And Properties
- Proteoglycans and glycosaminoglycans research
- Advanced Decision-Making Techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Immune Cell Function and Interaction
- Sulfur-Based Synthesis Techniques
- Sirtuins and Resveratrol in Medicine
- Advancements in Transdermal Drug Delivery
- Coccidia and coccidiosis research
- Asymmetric Synthesis and Catalysis
- EEG and Brain-Computer Interfaces
- Advanced Biosensing Techniques and Applications
Georgia State University
2016-2025
Dalian Medical University
2024-2025
Second Affiliated Hospital of Dalian Medical University
2024-2025
Jiangnan University
2019-2024
State Key Laboratory of Pollution Control and Resource Reuse
2024
Tongji University
2024
Nanjing Medical University
2023
Beijing Municipal Education Commission
2023
Affiliated Hospital of Qingdao University
2022
East China Normal University
2011-2022
Neutrophil aggregation and clearance are important factors affecting neuroinflammatory injury during acute ischemic stroke. Emerging evidence suggests that energy metabolism is essential for microglial functions, especially phagocytosis, which determines the degree of brain injury. Here, we demonstrate Resolvin D1 (RvD1), a lipid mediator derived from docosahexaenic acid (DHA), promotes phagocytosis neutrophils by microglia, thereby reducing neutrophil accumulation in alleviating...
A novel, efficient, and highly regioselective Lewis acid-catalyzed [3 + 2] cycloaddition of alkynes with azomethine ylides, which are easily obtained from N-tosylaziridines via C-C bond heterolysis at room temperature was developed. Moderate enantioselectivity (70% ee) can be achieved by the application commercially available chiral Pybox 7 as ligand.
An efficient and mild Ni(ClO(4))(2)-catalyzed [3+2] cycloaddition of N-tosylaziridines aldehydes via C-C bond cleavage was developed. The reaction proceeds with high diastereoselectivity regioselectivity leading to highly substituted 1,3-oxazolidines. Notably, this novel can be easily expanded gram level scale the thermal conditions cannot achieve same transformation.
Roles of internal epitopes and modification terminal in the glycan-binding events have been studied.
Multifunctional micelles based on a peptide–polymer for simultaneously targeting Aβ degradation and ROS scavenging AD therapy.
Sialic acids (Sias) are ubiquitously expressed on all types of glycans, typically as terminating residues. They usually link to galactose, N‐acetylgalactosamine, or other Sia residues, forming ligands many glycan‐binding proteins. An atypical linkage the C6 N‐acetylglucosamine (GlcNAc) has been identified in human milk oligosaccharides (HMOs, e.g., DSLNT) and tumor‐associated glycoconjugates. Herein, we achieved systematic synthesis these HMOs an enzymatic modular manner. The synthetic...
Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and terminal differentiation. Interleukin-22 (IL-22) the transcription factor Stat3 play pivotal roles in pathogenesis of psoriasis. CD147 transmembrane glycosylation protein that belongs to immunoglobulin superfamily. Our previous studies have shown marker high poor differentiation as well psoriasis susceptibility gene. The current study demonstrates highly expressed psoriatic lesions....
Poly‐N‐acetyllactosamine (poly‐LacNAc) is ubiquitously expressed on cell surface glycoconjugates, serving as the backbone of complex glycans and an extended scaffold that presents diverse glycan epitopes. The branching poly‐LacNAc, where internal galactose (Gal) residues have β1‐6 linked N‐acetylglucosamine (GlcNAc) attached, forms blood group I‐antigen, which closely associated with various physiological pathological processes including cancer progression. However, underlying mechanisms...
Poly‐N‐acetyllactosamine (poly‐LacNAc) is ubiquitously expressed on cell surface glycoconjugates, serving as the backbone of complex glycans and an extended scaffold that presents diverse glycan epitopes. The branching poly‐LacNAc, where internal galactose (Gal) residues have β1‐6 linked N‐acetylglucosamine (GlcNAc) attached, forms blood group I‐antigen, which closely associated with various physiological pathological processes including cancer progression. However, underlying mechanisms...
Utilizing polyion complexation, the formation of rod-like DNA condensates is driven by intrinsic rigidity supramolecular plasmid DNA. Upon interaction with polycationic block copolymers poly(ethylene glycol)-polylysine (PEG-PLys), these macromolecules undergo a regular self-folding process, during which double-stranded (dsDNA) transitions into single-stranded (ssDNA) at kinked junctions. Our investigations, employing transmission electron microscopy (TEM), unprecedentedly reveal absence PEG...
Two new azaphilone metabolites, named pseudohalonectrin A (1) and B (2), were isolated from the culture of aquatic fungus Pseudohalonectria adversaria YMF1.01019, originally separated submerged wood in Yunnan Province, China. Pseudohalonectrin assessed for their nematicidal activity against pine nematode Bursaphelenchus xylophilus structures defined after spectral analysis. This is first report secondary metabolites any member genus Pseudohalonectria.
ABSTRACT Escherichia coli transforms the methanogenic archaeon Methanococcus maripaludis at frequencies ranging from 0.2 × 10 −6 to 2 per recipient cell. Transformation requires cell-to-cell contact, oriT , and tra functions, is insensitive DNase I, otherwise displays hallmarks of conjugation.
The variation of amyloid β peptide (Aβ) concentration and Aβ aggregation are closely associated with the etiology Alzheimer's diseases (AD). interaction monosialoganglioside-rich neuronal cell membrane has been suggested to influence aggregation. Therefore, studies on mechanism sialic acids (SA) would greatly contribute better understanding pathogenesis AD. Herein, we report a novel approach for Aβ–SA analysis highly sensitive detection by mimicing surface presentation SA clusters through...
The present study was conducted to investigate the effects of dietary yeast ( Saccharomyces cerevisiae ) cell walls (YCW) from extract industry on performance and immune function cyclosporine A (CSA)-treated, immunosuppressed broiler chickens. total 240 day-old male broilers were allocated randomly into four treatments: (1) non-challenged control; (2) control+0·3 % YCW; (3) CSA-challenged group; (4) CSA-challenged+0·3 YCW. On days 1–4 22–25 age, subcutaneously injected with CSA or sterile...
Peripheral arterial diseases (PAD) have been reported to be the leading cause for limb amputations, and current therapeutic strategies including antiplatelet medication or intervene surgery are not clinically benefit patients with high-grade PAD. To this respect, revascularization based on angiogenetic vascular endothelial growth factor (VEGF) gene therapy was attempted potential treatment of critical Aiming transcellular delivery VEGF-encoding plasmid DNA (pDNA), we proposed elaborate...
Abstract An approach to highly functionalized donor‐acceptor aziridines by the aziridination of N ‐tosylimines and 2‐bromomalonates in presence sodium hydride under mild conditions has been developed. The high‐yielding reaction a relatively broad scope can be easily scaled up gram level.
Development of probes for accurate sensing and imaging biometals in situ is still a growing interest owing to their crucial roles cellular metabolism, neurotransmission, apoptosis. Among them, Zn2+ Cu2+ are two important cooperative closely related Alzheimer's disease (AD). Herein, we developed multifunctional probe based on self-assembling peptide nanoribbon ratiometric Zn2+, Cu2+, or simultaneously. Uniform (AQZ@NR) was rationally designed by coassembling Zn2+-specific ligand AQZ-modified...
In this study, phosphorescence emission and a strong excitation-wavelength dependent fluorescence has been found in large-scale graphene oxide (GO) nanosheets.