A5055658685- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Advanced biosensing and bioanalysis techniques
- Gestational Diabetes Research and Management
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- Folate and B Vitamins Research
- Bariatric Surgery and Outcomes
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Flavonoids in Medical Research
- Spectroscopy and Chemometric Analyses
- Immunotherapy and Immune Responses
- Concrete Corrosion and Durability
- Metal-Organic Frameworks: Synthesis and Applications
- Metabolism, Diabetes, and Cancer
- Pregnancy-related medical research
- Helicobacter pylori-related gastroenterology studies
- Fault Detection and Control Systems
- Glycosylation and Glycoproteins Research
- Obesity, Physical Activity, Diet
- Graphene and Nanomaterials Applications
Dalian University of Technology
2017-2025
Beijing Sport University
2019-2025
Dalian University
2017-2025
Zhejiang University
2022-2025
Shenyang Pharmaceutical University
2025
Yangtze University
2025
Tianjin Normal University
2023
Shanghai University
2022
Northwest A&F University
2022
Linyi University
2022
Pyroptosis, a unique lytic programmed cell death, inspired tempting implications as potent anti-tumor strategy in pertinent to its potentials stimulating immunity for eradication of primary tumors and metastasis. Nonetheless, rare therapeutics have been reported successfully stimulate pyroptosis. In view the intimate participation reactive oxygen species (ROS) pyroptosis, we attempted devise spectrum well-defined subcellular organelle (including mitochondria, lysosomes endoplasmic...
A NIR fluorescent probe exploiting the aldehyde group assisted thiolysis of dinitrophenyl ether strategy for H<sub>2</sub>S imaging in cells, tissues and mice.
Doxorubicin (DOX) is a widely-used effective antitumor agent. However, its clinical application limited due to side effects including anti-apoptotic defense of cancer cells caused by DOX-induced autophagy and deleterious in normal tissues. Therefore, this study, new folate (FA)-decorated amphiphilic bifunctional pullulan-based copolymer (named as FPDP) was developed an efficient nano-carrier for the co-delivery DOX short hairpin RNA Beclin1, pivotal autophage-related gene, enhance anticancer...
Small interfering RNA (siRNA) has garnered tremendous interest as a potential therapeutic tool because of its intriguing gene-silencing ability. Toward the success in manufacture siRNA therapeutics for treatment choroidal neovascularization (CNV), conjugated with dual functional units membrane-penetrating heptafluoropropyl and age-related macular degeneration-targeting cyclic Arg-Gly-Asp (RGD) peptide was attempted transcellular transportation into cell interiors. Of note, RGD allowed...
Nanomedicine developed to date by means of directly encapsulating cytotoxins suffers from crucial drawbacks, including premature release and detoxification prior arrival at pharmaceutics targets. To these respects, redox-responsive polymeric prodrugs platinum (Pt) camptothecin (CPT), selectively concomitantly activated in the cytoplasm, were elaborated manufacture dual prodrug nanomedicine. Herein, multiple CPTs conjugated poly(lysine) (PLys) segments block copolymeric poly(ethylene glycol)...
Open AccessCCS ChemistryRESEARCH ARTICLE1 Feb 2022Molecular Structural Evolution of Near-Infrared Cationic Aggregation-Induced Emission Luminogens: Preclinical Antimicrobial Pathogens Activities and Tissues Regeneration Haidong Li†, Liuwei Zhang†, Jingjing Han†, Dayeh Kim†, Heejeong Kim, Jeongsun Ha, Jingyun Wang Juyoung Yoon Li† Department Chemistry Nanoscience, Ewha Womans University, Seoul 03760 , Zhang† State Key Laboratory Fine Chemicals, Dalian University Technology, 116024 School...
The development of anti-tumor nanomedicines grapples with the critical challenge achieving sustained retention and massive intratumoral distributions chemotherapeutics. Herein, we attempted multifaceted prodrug nanomedicine precise spatiotemporal responsiveness, integrating dual prodrugs-redox-responsive SN38 pH-responsive thrombin ensuring drug release coinciding striking tumor acidity reductive stress, while its spatial selectivity is directed by overexpression integrins on cancerous...
Tumors managing to exempt from immune clearance are attributable their overexpressed suppressive molecules (CD47, PD-L1, etc.). Leadingly, the checkpoint blockade-based chemoimmunotherapy by means of knockdown these immunosuppressive checkpoints, together with immunogenetic chemotherapeutics, is perceived be a valid therapeutic strategy for improving anti-tumor outcomes. Herein, chemotherapeutic camptothecin was covalently introduced into an intriguing multifaceted nanomedicine. Note that...
Compared to the traditional processing method, fresh can significantly enhance preservation of biologically active ingredients and reduce time. This study evaluated influences based on different drying conditions (sun drying, oven shade drying) in roots rhizomes S. miltiorrhiza. High-performance liquid chromatography (HPLC) was utilized determine contents six The data were analyzed by fingerprint similarity evaluation, hierarchical cluster analysis (HCA) principal component (PCA). results...