A5082114930- Alkaloids: synthesis and pharmacology
- Ginkgo biloba and Cashew Applications
- Gut microbiota and health
- Peroxisome Proliferator-Activated Receptors
- Ginger and Zingiberaceae research
- Chronic Kidney Disease and Diabetes
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Insect Utilization and Effects
- Plant biochemistry and biosynthesis
- Garlic and Onion Studies
- Photosynthetic Processes and Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Essential Oils and Antimicrobial Activity
- Immune cells in cancer
- COVID-19 Pandemic Impacts
- Fermentation and Sensory Analysis
- Complementary and Alternative Medicine Studies
- Plant-based Medicinal Research
- Traditional and Medicinal Uses of Annonaceae
- Berberine and alkaloids research
- Food Quality and Safety Studies
- Animal and Plant Science Education
- Pharmacological Effects of Medicinal Plants
- Mass Spectrometry Techniques and Applications
China Pharmaceutical University
2018-2025
State Key Laboratory of Natural Medicine
2025
Ginkgolides are secondary metabolites unique to Ginkgo biloba with the potential prevent and treat cardiovascular cerebrovascular diseases. Although biosynthetic pathways of ginkgolides have been partly uncovered, mechanism regulating their biosynthesis is still largely unknown. Here, using multiomic genetic analyses, we report identification a transcription factor, named ETHYLENE RESPONSE FACTOR ASSOCIATED WITH GINKGOLIDE BIOSYNTHESIS (GbEAG), as critical regulator ginkgolide biosynthesis....
Since the outbreak of COVID-19 pandemic, Ghana has recorded a total 130, 727 confirmed cases with 1,207 deaths at time writing this article. The pandemic had significant influence on nations and regions all around world since it started is no exception. This systematic review discusses measures in Ghana, impact import export Agricultural inputs food, as well local food system actors. In second part, to prevent insecurity during emerging lessons, building resilience have also been presented....
Salvianolic acid B (Sal B), the main water-soluble compound in Salvia miltiorrhiza, is known to exhibit anti-inflammatory activity, however, underlying mechanism(s) not completely uncovered. In this study, Sal inhibited lipopolysaccharide (LPS)-induced M1 activation and promoted transformation of macrophages from M1- M2-type polarization. The altered lipid profiles LPS-induced RAW 264.7 were partly restored by treatment. At proteomic level, a total 5612 proteins identified 432 significantly...
Abstract Objectives This study sought to determine the quality of essential oil from Xylopia aethiopica fruits different geographical origins using GC-MS-based metabolomics, bacterial quorum sensing and anti-inflammation assessment. Methods Essential was obtained eight batches X. Ghana Nigeria by hydrodistillation, characterized gas chromatography–mass spectrometry differences therein found metabolomics. The respective antibacterial activity oils tested against four strains: two...
Abstract Objectives This study sought to investigate the differences in quality of dried ginger samples obtained from two places Zambia, Lusaka and Copperbelt terms their secondary metabolite heavy metals content. Methods Ten eight batches obtained, respectively, were analysed using untargeted Q/TOF-MS-based metabolomics inductively coupled plasma optical emission spectroscopy (ICP-OES). Key findings The approach yielded 11 differential metabolites that clearly discriminated between...
Renal fibrosis, inflammation, and gut dysbiosis are all linked to chronic kidney disease (CKD). Here we show that Bacteroides ovatus protects against renal fibrosis. Mechanistically, B. enhances intestinal hyodeoxycholic acid (HDCA) levels by upregulating a strain of bacteria, Clostridium scindens, has the capacity for direct HDCA production in mice. significantly promoted GLP-1 secretion expression TGR5 downregulating farnesoid X receptor (FXR) gut. Activation GLP-1R attenuates fibrosis...