A5040028122- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Nuclear Receptors and Signaling
- Cancer-related gene regulation
- Folate and B Vitamins Research
- Genetics and Neurodevelopmental Disorders
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Metabolism and Genetic Disorders
- Cancer, Lipids, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA regulation and disease
- Cancer-related Molecular Pathways
- Ovarian cancer diagnosis and treatment
- Immune cells in cancer
- Radiomics and Machine Learning in Medical Imaging
Tianjin Medical University Cancer Institute and Hospital
2021-2025
Air Force Medical University
2025
Hebei Medical University
2018-2024
Abstract Circular RNA (circRNA) is a type of non-coding that widely expressed in mammals. It highly conserved and abundantly the brain. Here, we report regulatory role circRNA derived from pantothenate kinase 1 (Pank1) gene (circ-Pank1) Parkinson’s disease (PD). Circ-Pank1 substantia nigra (SN) PD model mice treated with rotenone MN9D cell dopaminergic neurons. The circ-Pank1 knockdown ameliorated neuron damage locomotor dysfunction after treatment rotenone. We found could adsorb miR-7a-5p...
Immune checkpoint inhibitors (ICIs) represent a promising treatment for hepatocellular carcinoma (HCC) due to their capacity abundant lymphocyte infiltration. However, some patients with HCC respond poorly ICI therapy the presence of various immunosuppressive factors in tumor microenvironment. Our research reveals that macrophage-coated cluster (MCTC) signifies unique spatial structural organization correlating diminished recurrence-free survival and overall total 572 cases from 3 internal...
Background: Transarterial chemoembolization (TACE) is the primary treatment modality for advanced HCC, yet its efficacy assessment and prognosis prediction largely depend on imaging serological markers that possess inherent limitations in terms of real-time capability, sensitivity, specificity. Here, we explored whether multiple features cell-free mitochondrial DNA (cf-mtDNA), including copy number, mutations, fragmentomics, could be used to predict response patients with HCC undergoing TACE...
ABSTRACT Not all ovarian cancer patients with homologous recombination deficiency, especially those germline BRCA mutations, can benefit from platinum‐based and targeted therapy. Our study aimed to determine the value of nonsense‐mediated mRNA decay, which these mutations. The retrospective analysis 797 was performed using two public cohorts one in‐house cohort. We developed a prediction algorithm for decay discriminate between trigger escape status, finding that status indicated better...
Antioxidant response transcription factor nuclear erythroid-2-related 2 (Nrf2/Nfe2l2) is a neuroprotective agent in learning and memory impairment. This study provides new perspective to explore the regulatory mechanisms of Nrf2. Here, we found that Nrf2 regulated circular RNA circ-Vps41 increase hippocampal synaptic plasticity; bound Vps41 promoter activate gene promote expression circ-Vps41; positively correlated with Nrf2, plasticity, but negatively reactive oxygen species; promoted...
Background/Aims: The nuclear factor erythroid 2-related 2 (Nrf2)-antioxidant response element (ARE) pathway plays a protective role in both acute neuronal damage and chronic neurodegeneration-related oxidative stress. Circular RNAs (circRNAs) are involved with various diseases the central nervous system (CNS). This study aimed to identify key circRNAs Nrf2-neuroprotection against Methods: differentially expressed (DEcircRNAs) substantia nigra corpus striatum between Nrf2 (-/-) (+/+) mice...
Nrf2 (nuclear factor, erythroid 2 like 2) is believed to play a major role in neurodegenerative diseases. The present study attempts investigate the hippocampal circRNA and lncRNA expression profiles associated with Nrf2-mediated neuroprotection. mRNA, of (-/-) mice were determined by microarray analysis. Bioinformatics analyses, including identification differentially expressed mRNAs (DEmRNAs), circRNAs (DEcircRNAs) lncRNAs (DElncRNAs), DEcircRNA-miRNA-DEmRNA interaction network...
The flippase ATPase class I type 8b member 1 (ATP8B1) is essential for maintaining the stability and polarity of epithelial membrane can translocate specific phospholipids from outer to inner cell. Although ATP8B1 plays important roles in cell functions, has been poorly studied tumors its prognostic value patients with lung squamous carcinoma (LUSC) remains unclear. By investigating whole genomic expression profiles LUSC samples Cancer Genome Atlas (TCGA) database Tianjin Medical University...
Abstract N6-methyladenosine (m 6 A) is abundant in the mammalian brain and considered to have a wide range of effects on learning memory. Here, we found that upregulated methyltransferase-like protein 16 (METTL16) hippocampal tissues Morris water maze (MWM)-trained mice contributed improved memory formation synaptic plasticity. Mechanismly, METTL16 promoted expression methionine adenosyltransferase 2A (MAT2A) by m A methylation MAT2A mRNA-3′UTR-end increase its stability, this involved...
Age is an established risk factor for neurodegenerative disorders. Aging-related cognitive decline a common cause of memory impairment in aging individuals, which hippocampal synaptic plasticity and hippocampus-dependent formation are damaged. Circular RNAs (circRNAs) have been reported many disorders, but their role aging-related unclear.Methods: In this study, we aimed to investigate the effects circ-Vps41 on explore potential mechanisms. Here, D-galactose was used produce conventional...
The aim of our study is to find a better way identify group papillary thyroid carcinoma (PTC) with more aggressive behaviors and provide prediction model for lymph node metastasis assist in clinic practice. Targeted sequencing DNA/RNA was used detect genetic alterations. Gene expression level measured by quantitative real-time PCR, western blotting or immunohistochemistry. CCK8, transwell assay flow cytometry were investigate the effects concomitant gene alterations PTC. LASSO-logistics...
Background Glioma is the most common primary malignant brain tumor with high mortality and poor prognosis. Hepcidin a fascinating iron metabolism regulator. However, prognostic value of hepcidin HAMP in gliomas its correlation immune cell infiltration remain unclear. Here, we comprehensively elucidate potential role gliomas. Methods gene expression clinical characteristics glioma were analyzed using CGGA, TCGA, Rembrandt Gravendeel databases. A survival analysis was conducted Kaplan–Meier...
In the central nervous system, nuclear factor erythroid-2-related 2 (Nrf2) protects neurons from oxidant injury, thereby ameliorating neurodegeneration. We explored key circular RNAs (circRNAs) and long non-coding (lncRNAs) involved in Nrf2-induced neuroprotection. used microarrays to examine circRNAs (DEcircRNAs), lncRNAs (DElncRNAs) mRNAs (DEmRNAs) differentially expressed between Nrf2 (+/+) (-/-) mice identified DEcircRNA/DElncRNA-miRNA-DEmRNA interaction networks. total, 197 DEcircRNAs,...
Abstract N6-methyladenosine (m 6 A) is abundant in the mammalian brain and considered to have a wide range of effects on learning memory. Here, we found that upregulated methyltransferase-like protein 16 (METTL16) hippocampal tissues Morris water maze (MWM)-trained mice contributed improved memory formation synaptic plasticity. Mechanismly, METTL16 promoted expression methionine adenosyltransferase 2A (MAT2A) by m A methylation MAT2A mRNA 3′UTR-end increase its stability, this involved...