A5033672811- Thyroid Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- AI in cancer detection
- S100 Proteins and Annexins
- Nanoparticle-Based Drug Delivery
- Prostate Cancer Treatment and Research
- Artificial Intelligence in Healthcare and Education
- Hepatocellular Carcinoma Treatment and Prognosis
- Thyroid and Parathyroid Surgery
- RNA modifications and cancer
- Protein Tyrosine Phosphatases
- Head and Neck Anomalies
- Optical Coherence Tomography Applications
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Extracellular vesicles in disease
- Cervical Cancer and HPV Research
- Molecular Biology Techniques and Applications
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Ultrasound and Cavitation Phenomena
- RNA Research and Splicing
Tianjin Medical University Cancer Institute and Hospital
2020-2025
National Clinical Research
2022-2025
Central lymph node metastasis (CLNM) is a predictor of poor prognosis for papillary thyroid carcinoma (PTC) patients. The options surgeon operation or follow-up depend on the state CLNM while accurate prediction challenge radiologists. present study aimed to develop and validate an effective preoperative nomogram combining deep learning, clinical characteristics ultrasound features predicting CLNM.In this study, 3359 PTC patients who had undergone total thyroidectomy lobectomy from two...
Percutaneous local thermal therapy, containing radio frequency and microwave ablation, is widely utilized in the clinical management of hepatocellular carcinoma (HCC) due to its minimal invasiveness favorable therapeutic outcomes. However, further development limited by a prolonged ablation duration risk excessive heating. Magnetic hyperthermia therapy (MHT) provides new perspective for percutaneous tumor superior tissue penetration capability safety. Herein, an iron foam-agarose gel-drug...
Purpose Clinically, the risk stratification of thyroid nodules is usually used to formulate next treatment plan. The American College Radiology (ACR) imaging reporting and data system (TI‐RADS) a type medical standard widely in classification diagnosis. It divides nodule’s ACR TI‐RADS level into five levels by quantitative scoring, from benign high suspicion malignancy. However, such assessment often relies on radiologists’ experience time consuming. So computer‐aided diagnosis necessary....
Abstract The use of the BRAF inhibitor vemurafenib exhibits drug resistance in treatment thyroid cancer (TC), and finding more effective multitarget combination therapies may be an important solution. In present study, we found strong correlations between Ref-1 high expression mutation, lymph node metastasis, TNM stage. oxidative stress environment induced by structural activation upregulates Ref-1, which caused intrinsic PTC to vemurafenib. Combination inhibition redox function could...
Chemotherapy remains the primary therapeutic approach for advanced Hepatocellular Carcinoma (HCC). The effect of chemotherapy is limited and toxic side effects are serious. aim this study to develop a nanobubble that ultrasonically responsive reduce direct chemotherapy.
Abstract Alternative splicing (AS) provides the primary mechanism for producing protein diversity. There is growing evidence that AS involved in development and progression of cancers. The rapid accumulation high‐throughput sequencing technologies clinical data sets offers an opportunity to systematically profile relationship between mRNA variants outcomes. However, there a lack systematic analysis prostate cancer: Download RNA‐seq information from Cancer Genome Atlas (TCGA) portal. Evaluate...
Prolonged treatment of HER2+ breast cancer with lapatinib (LAP) causes cellular senescence and acquired drug resistance, which often associating poor prognosis for patients. We aim to explore the correlation between LAP resistance in cancer, screen molecular marker reversible senescence, construct targeted nanobubbles ultrasound imaging dynamically evaluate resistance.In this study, we established a new model using cells found that contributed cancer. Then, identified ecto-5'-nucleotidase...
Assessment of thyroid nodules is usually relied on the experience radiologist and time-consuming. Classification model cannot only reduce burden physicians but also provide objective recommendations. However, most classification models based deep learning simply give a prediction result benignity or malignancy nodules; thus, have no way knowing how gets due to black-box nature neural networks. In this work, we integrate explainability directly into outputs generated by through combining...
The aim of our study is to find a better way identify group papillary thyroid carcinoma (PTC) with more aggressive behaviors and provide prediction model for lymph node metastasis assist in clinic practice. Targeted sequencing DNA/RNA was used detect genetic alterations. Gene expression level measured by quantitative real-time PCR, western blotting or immunohistochemistry. CCK8, transwell assay flow cytometry were investigate the effects concomitant gene alterations PTC. LASSO-logistics...
Lateral lymph node metastasis (LLNM) is frequent in papillary thyroid carcinoma (PTC) and associated with a poor prognosis. This study aimed to developed clinical-ultrasound (Clin-US) nomogram predict LLNM patients PTC. In total, 2612 PTC from two hospitals (H1: 1732 the training cohort 578 internal testing cohort; H2: 302 external cohort) were retrospectively enrolled. The associations between preoperative clinical sonographic characteristics evaluated by univariable multivariable logistic...
Thyroid cancer is the most common malignancy in endocrine system, with its early manifestation being presence of thyroid nodules. With advantages convenience, noninvasiveness, and a lack radiation, ultrasound currently first-line screening tool for clinical diagnosis The use artificial intelligence to assist an emerging technology. This paper proposes optical neural networks potential application auxiliary nodules.Ultrasound images obtained from January 2013 December 2018 at Institute...
Background: Hepatitis B virus X protein (HBx) is an indispensable progression factor in Hepatocellular Carcinoma (HCC). CCL15 could be a peculiar proteomic biomarker of HCC with tumorigenesis and tumor invasion. Objective: The aim study was to explore the relationship between HBx expression HCC. Methods: HBV-positive pathological tissue samples corresponding adjacent non-tumor liver tissues were collected. analyzed by immunohistochemistry, real-time Polymerase Chain Reaction (PCR), western...
Purpose Lateral lymph node metastasis (LLNM) is very common in medullary thyroid carcinoma (MTC), but there still controversy about how to manage cervical lateral nodes, especially for clinically negative MTC. The aim of this study develop and validate a nomogram predicting LLNM risk Materials methods A total 234 patients from two hospitals were retrospectively enrolled divided into positive group based on the pathology. correlation between preoperative clinical ultrasound variables...
Annexins family (ANXAs), as a Ca
Abstract Background: The linkage between IDO2 expression and cancer progression is still unclear, particularly in medullary thyroid carcinoma (MTC). Our purpose to unveil the potential correlations status, clinical-pathological parameters, patients’ prognosis, possible immunomodulatory functions MTC. Methods: Immunohistochemical levels of were evaluated resected MTC surgical specimens corresponding lymph nodes. CD4+ T cell infiltration was also by immunohistochemical analysis tissues....
Background: Alternative splicing (AS) provides the primary mechanism for producing protein diversity. There is growing evidence that AS involved in development and progression of cancers. The rapid accumulation high-throughput sequencing technologies clinical data sets offers an opportunity to systematically profile relationship between mRNA variants outcomes. However, there a lack systematic analysis alternative prostate cancer. Methods: Download RNA-Seq information from TCGA portal....
Abstract Background: Annexins family (ANXAs), as a Ca2+-dependent, phospholipid-binding protein super family, participated in wide variety of biological activities and has been reported to be dysregulated numerous types human cancers. Evidence from cell lines tissues indicates that ANAXs are involved kidney clear renal carcinoma (KIRC) tumorigenesis. However, their prognostic value expression pattern associated with KIRC remain elucidated. Methods: We visited public databases including...